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公开(公告)号：US20230201327A1
公开(公告)日：2023-06-29
申请号：US17924784
申请日：2021-05-13
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
CPC分类号： A61K39/12 , A61P37/04 , A61K2039/552
摘要： Provided is a polynucleotide encoding a respiratory syncytial virus (RSV) variant having an attenuated phenotype comprising a modified RSV genome or antigenome that encodes a mutant RSV protein P that differs from a parental RSV protein P at one or more amino acid residues. In some embodiments, the polynucleotide is recombinant. The invention also relates to methods of vaccinating an animal with the RSV variant or a pharmaceutical composition containing the RSV variant or inducing an immune response by administering the RSV variant to an animal, and further relates to methods of producing an RSV variant vaccine. In some embodiments, the animal is a human.
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公开(公告)号：US10953083B2
公开(公告)日：2021-03-23
申请号：US16061316
申请日：2016-12-12
摘要： Reported herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype in which the native positions of the NS1 and/or NS2 genes in the RSV genome are shifted to a higher position, that is at positions that are more distal to the promoter. The changes in the gene positions may be present in combination with mutations at other loci to achieve desired levels of attenuation and immunogenicity. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.
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公开(公告)号：US12071632B2
公开(公告)日：2024-08-27
申请号：US17049916
申请日：2019-04-23
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C12N15/86 , A61K39/155 , A61P31/14 , A61K39/00
CPC分类号： C12N15/86 , A61K39/155 , A61P31/14 , A61K2039/5256 , A61K2039/543 , C12N2760/18534 , C12N2760/18544 , C12N2760/18551
摘要： Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
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公开(公告)号：US11918638B2
公开(公告)日：2024-03-05
申请号：US17183227
申请日：2021-02-23
CPC分类号： A61K39/12 , C12N7/00 , C12N7/04 , A61K2039/5254 , A61K2039/55 , C12N2760/18521 , C12N2760/18534 , C12N2760/18551
摘要： Reported herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype in which the native positions of the NS1 and/or NS2 genes in the RSV genome are shifted to a higher position, that is at positions that are more distal to the promoter. The changes in the gene positions may be present in combination with mutations at other loci to achieve desired levels of attenuation and immunogenicity. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.
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公开(公告)号：US20210189425A1
公开(公告)日：2021-06-24
申请号：US17049916
申请日：2019-04-23
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C12N15/86 , A61K39/155 , A61P31/14
摘要： Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
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6.发明授权公开(公告)号：US10980872B2
公开(公告)日：2021-04-20
申请号：US16425725
申请日：2019-05-29
IPC分类号： A61K39/155 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
摘要： Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenuation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
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7.发明授权公开(公告)号：US09957486B2
公开(公告)日：2018-05-01
申请号：US14766620
申请日：2014-02-07
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , The Research Foundation for the State University of New York
发明人： Peter L. Collins , Cyril Le Nouën , Linda G. Brock , Ursula J. Buchholz , Joshua Marc DiNapoli , Steffen Mueller , Eckard Wimmer
IPC分类号： C12N7/00 , A61K39/155 , C07K14/005 , A61K39/00
CPC分类号： C12N7/00 , A61K39/155 , A61K2039/5254 , A61K2039/53 , A61K2039/55 , C07K14/005 , C12N2760/00021 , C12N2760/00034 , C12N2760/00062 , C12N2760/18522 , C12N2760/18534 , C12N2760/18561 , C12N2760/18562
摘要： Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
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8.发明授权公开(公告)号：US09624475B2
公开(公告)日：2017-04-18
申请号：US14394226
申请日：2013-03-13
IPC分类号： C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18534 , C12N2760/18562
摘要： Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
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公开(公告)号：US11975063B2
公开(公告)日：2024-05-07
申请号：US17590631
申请日：2022-02-01
发明人： Peter L. Collins , Ursula J. Buchholz , Bo Liang , Shirin Munir
IPC分类号： A61K39/12 , A61K39/00 , C07K14/005 , C12N15/86
CPC分类号： A61K39/12 , C07K14/005 , C12N15/86 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/575 , C12N2760/18534 , C12N2760/18571 , C12N2760/18643
摘要： Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing Respiratory Syncytial Virus (RSV) G protein or a recombinant RSV G protein, as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the RSV G protein or the recombinant RSV G protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to RSV and HPIV3 in a subject.
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公开(公告)号：US11332721B2
公开(公告)日：2022-05-17
申请号：US16877277
申请日：2020-05-18
IPC分类号： C12N7/00 , A61K39/12 , C07K14/005 , A61K39/155 , A61K39/00
摘要： Provided herein are novel recombinant respiratory syncytial viruses (RSV) having an attenuated phenotype that contain mutations in the M2-2 open reading frame that interfere with the expression of the M2-2 protein. The M2-2 mutations may be present in combination with mutations at other loci. Using methods described herein, combinations of mutations are provided to achieve desired levels of attenuation. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Also provided are polynucleotide sequences of the described viruses, as well as methods for producing and using the viruses.
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