公开(公告)号：US09913885B2

公开(公告)日：2018-03-13

申请号：US15207271

申请日：2016-07-11

申请人： The Trustees of the University of Pennsylvania ,  Inovio Pharmaceuticals, Inc.

发明人： David Weiner ,  Jian Yan ,  Bernadette Ferraro ,  Niranjan Y. Sardesai ,  Mathura P. Ramanathan

IPC分类号： C07K14/00 ,  A61K39/00 ,  C12N9/48 ,  C12N9/64 ,  C07K14/47

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/4748 ,  C12N9/485 ,  C12N9/6424 ,  C12Y116/01 ,  C12Y304/17021 ,  C12Y304/21077

摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.

公开(公告)号：US20160361403A1

公开(公告)日：2016-12-15

申请号：US15207271

申请日：2016-07-11

申请人： The Trustees of the University of Pennsylvania ,  Inovio Pharmaceuticals, Inc.

发明人： David Weiner ,  Jian Yan ,  Bernadette Ferraro ,  Niranjan Y. Sardesai ,  Mathura P. Ramanathan

IPC分类号： A61K39/00 ,  C12N9/64 ,  C07K14/47 ,  C12N9/48

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/4748 ,  C12N9/485 ,  C12N9/6424 ,  C12Y116/01 ,  C12Y304/17021 ,  C12Y304/21077

摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.

公开(公告)号：US20230338489A1

公开(公告)日：2023-10-26

申请号：US18323577

申请日：2023-05-25

申请人： Immatics Biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C07K7/08 ,  C12N15/115 ,  C12N5/0783 ,  C07K14/71 ,  C07K14/725 ,  C07K16/28 ,  C12Q1/6886 ,  C07K16/18 ,  G01N33/574 ,  C07K14/47 ,  C07K16/30 ,  C07K7/06 ,  C07K14/72 ,  C12N9/12 ,  C07K16/38 ,  C07K14/81 ,  C07K16/40 ,  C12N9/02 ,  C07K14/705 ,  G16B25/00 ,  G16B25/10

CPC分类号： A61K39/0011 ,  C07K7/08 ,  C12N15/115 ,  C12N5/0638 ,  C07K14/71 ,  C07K14/7051 ,  C07K16/2863 ,  C12Q1/6886 ,  C07K16/18 ,  G01N33/57484 ,  C07K14/4748 ,  C07K16/30 ,  C07K7/06 ,  C12N5/0636 ,  C07K16/2869 ,  C07K14/721 ,  C12Y207/07031 ,  C12N9/1264 ,  C07K16/38 ,  C07K14/8135 ,  C07K14/47 ,  C12Y116/01 ,  C07K16/40 ,  C12N9/0091 ,  C07K14/705 ,  C07K16/28 ,  G16B25/00 ,  G16B25/10 ,  C07K2319/40 ,  A61K35/17

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20170189513A1

公开(公告)日：2017-07-06

申请号：US15375058

申请日：2016-12-09

申请人： immatics biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C07K14/72 ,  C12N15/115 ,  C07K16/40 ,  C07K16/28 ,  C07K14/725 ,  C12N9/12 ,  C12N5/0783

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/71 ,  C07K14/721 ,  C07K14/8135 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/40 ,  C12N5/0636 ,  C12N5/0638 ,  C12N9/0091 ,  C12N9/1264 ,  C12N15/115 ,  C12N2310/16 ,  C12N2502/11 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y116/01 ,  C12Y207/07031 ,  G01N33/57484 ,  G01N2333/47 ,  G06F19/20

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20170189512A1

公开(公告)日：2017-07-06

申请号：US15375051

申请日：2016-12-09

申请人： immatics biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C12N15/115 ,  C07K16/40 ,  C07K14/725 ,  C12N9/12 ,  C12N5/0783

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/71 ,  C07K14/721 ,  C07K14/8135 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/40 ,  C12N5/0636 ,  C12N5/0638 ,  C12N9/0091 ,  C12N9/1264 ,  C12N15/115 ,  C12N2310/16 ,  C12N2502/11 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y116/01 ,  C12Y207/07031 ,  G01N33/57484 ,  G01N2333/47 ,  G06F19/20

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20170189506A1

公开(公告)日：2017-07-06

申请号：US15374882

申请日：2016-12-09

申请人： immatics biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C12N15/115 ,  C07K16/30 ,  C07K14/725 ,  C07K14/47 ,  C12N5/0783

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/71 ,  C07K14/721 ,  C07K14/8135 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/40 ,  C12N5/0636 ,  C12N5/0638 ,  C12N9/0091 ,  C12N9/1264 ,  C12N15/115 ,  C12N2310/16 ,  C12N2502/11 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y116/01 ,  C12Y207/07031 ,  G01N33/57484 ,  G01N2333/47 ,  G06F19/20

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20170189505A1

公开(公告)日：2017-07-06

申请号：US15374452

申请日：2016-12-09

申请人： immatics biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C07K7/08 ,  C12N5/0783 ,  C12N15/115 ,  G01N33/574 ,  G06F19/20 ,  C12Q1/68 ,  C07K14/725 ,  C07K7/06 ,  C07K16/18

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/71 ,  C07K14/721 ,  C07K14/8135 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/40 ,  C12N5/0636 ,  C12N5/0638 ,  C12N9/0091 ,  C12N9/1264 ,  C12N15/115 ,  C12N2310/16 ,  C12N2502/11 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y116/01 ,  C12Y207/07031 ,  G01N33/57484 ,  G01N2333/47 ,  G06F19/20

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20160166668A1

公开(公告)日：2016-06-16

申请号：US15048126

申请日：2016-02-19

申请人： CureVac AG

发明人： Karl-Josef KALLEN ,  Mariola FOTIN-MLECZEK ,  Ulrike GNAD-VOGT ,  Thomas LANDER

IPC分类号： A61K39/00 ,  C07K14/47 ,  C12N9/16 ,  C12N9/64 ,  C12N9/48 ,  C07K14/705 ,  C12N9/02

CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/4727 ,  C07K14/705 ,  C12N9/0091 ,  C12N9/16 ,  C12N9/485 ,  C12N9/6424 ,  C12Y116/01 ,  C12Y301/03002 ,  C12Y304/17021 ,  C12Y304/21077

摘要： The present invention relates to a composition comprising at least one mRNA encoding a combination of antigens capable of eliciting an (adaptive) immune response in a mammal, wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate-Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), STEAP (Six Transmembrane Epithelial Antigen of the Prostate), MUC1 (Mucin 1) and PAP (Prostatic acid phosphatase). The invention furthermore relates to a vaccine comprising at least one mRNA encoding such a combination of antigens and to the use of said composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of prostate adenocarcinoma, locally limited, locally advanced, metastatic, castration-resistant (hormone-refractory), metastatic castration-resistant and non-metastatic castration-resistant prostate cancers, and diseases or disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the composition and/or the vaccine.

摘要翻译： 本发明涉及一种组合物，其包含编码能够在哺乳动物中引发（适应性）免疫应答的抗原组合的至少一种mRNA，其中所述抗原选自PSA（前列腺特异性抗原），PSMA（ 前列腺特异性膜抗原），PSCA（前列腺干细胞抗原），STEAP（前列腺的六个跨膜上皮抗原），MUC1（粘蛋白1）和PAP（前列腺酸性磷酸酶）。 本发明还涉及包含至少一种编码抗原组合的mRNA和用于所述组合物（用于制备疫苗）和/或用于引发用于治疗的（适应性）免疫应答的疫苗）的疫苗的疫苗 的前列腺癌（PCa），优选前列腺腺癌，局部限制的，局部晚期的，转移的，去阉割的（激素难治的），转移性去阉割抗性和非转移性去钙抗性前列腺癌，以及与之相关的疾病或病症。 最后，本发明涉及试剂盒，特别涉及含有组合物和/或疫苗的试剂盒。

公开(公告)号：US20190015492A1

公开(公告)日：2019-01-17

申请号：US16116323

申请日：2018-08-29

申请人： Immatics Biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C12N15/115 ,  C07K14/72 ,  G01N33/574 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/705 ,  C07K14/725 ,  C07K14/71 ,  C12N9/12 ,  C12N9/02 ,  C12N5/0783 ,  G06F19/20 ,  C12Q1/6886 ,  C07K16/40 ,  C07K16/38 ,  C07K16/30 ,  C07K16/28 ,  C07K16/18 ,  C07K14/81 ,  A61K38/00 ,  A61K35/17

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/71 ,  C07K14/721 ,  C07K14/8135 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/40 ,  C12N5/0636 ,  C12N5/0638 ,  C12N9/0091 ,  C12N9/1264 ,  C12N15/115 ,  C12N2310/16 ,  C12N2502/11 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y116/01 ,  C12Y207/07031 ,  G01N33/57484 ,  G01N2333/47 ,  G16B25/00

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20170189510A1

公开(公告)日：2017-07-06

申请号：US15375037

申请日：2016-12-09

申请人： immatics biotechnologies GmbH

发明人： Andrea MAHR ,  Toni WEINSCHENK ,  Colette SONG ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH

IPC分类号： A61K39/00 ,  C12N15/115 ,  C07K16/18 ,  C07K14/47 ,  C12N5/0783

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/71 ,  C07K14/721 ,  C07K14/8135 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/2869 ,  C07K16/30 ,  C07K16/38 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/40 ,  C12N5/0636 ,  C12N5/0638 ,  C12N9/0091 ,  C12N9/1264 ,  C12N15/115 ,  C12N2310/16 ,  C12N2502/11 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Y116/01 ,  C12Y207/07031 ,  G01N33/57484 ,  G01N2333/47 ,  G06F19/20

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.