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    Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them
    1.
    发明授权
    Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them 失效
    硫代磷酸酯衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：US06200962B1

    公开(公告)日：2001-03-13

    申请号：US08849122

    申请日：1997-08-07

    申请人： Oren Tirosh ,  Joshua Katzhendler ,  Isaac Ginsburg ,  Yehezkel Barenholz ,  Ron Kohen

    发明人： Oren Tirosh ,  Joshua Katzhendler ,  Isaac Ginsburg ,  Yehezkel Barenholz ,  Ron Kohen

    IPC分类号： A61K31664

    CPC分类号： A61Q17/00 ,  A61K8/55 ,  A61K31/664 ,  A61K2800/522

    摘要： The invention relates to a compound of formula (I) in which X1 and X2 each independently represents an oxygen or nitrogen atom; p,m and n are each independently an integer of at least 2; R, R1 and R2 each independently represents a hydrogen atom; a halogen atom; an optionally substituted straight-chained or branched alkyl alkenyl or alkynyl radical; a group R3O in which R3 is hydrogen atom, an optionally substituted straight-chained or branched alkyl alkenyl or alkynyl radical; optionally substituted acyl or optionally substituted aryl or heteroaryl; a group R4O(O)C in which R4 is a hydrogen atom or an optionally straight-chained or branched alkyl, alkenyl or allkynyl radical; a group —SR5 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl alkenyl or alkynyl radical; a group —NR6R7 in which R6 and R7 each independently represents a hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl; or an optionally substituted phosphate ester group. The invention also relates to processes., for The preparation of compounds of the formula and to pharmaceutical compositions containing the same.

    摘要翻译： 本发明涉及式（I）化合物，其中X 1和X 2各自独立地表示氧或氮原子; p，m和n各自独立地为至少2的整数; R，R 1和R 2各自独立地表示氢原子; 卤素原子; 任选取代的直链或支链烷基烯基或炔基; R 3为氢原子的基团R 3 O，任选取代的直链或支链烷基烯基或炔基; 任选取代的酰基或任选取代的芳基或杂芳基; R 4是氢原子或任选的直链或支链烷基，烯基或全炔基的基团R4O（O）C; 基团-SR 5是氢原子或任选取代的直链或支链烷基烯基或炔基; R 6和R 7各自独立地表示氢原子的基团-NR 6 R 7，任选取代的直链或支链烷基，烯基或炔基; 任选取代的酰基; 或任选取代的磷酸酯基团。 本发明还涉及制备下式化合物和含有该化合物的药物组合物的方法。