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1.发明授权Ceramide analogs, process for their preparation and their use as antitumor agents 失效神经酰胺类似物，其制备方法及其作为抗肿瘤剂的用途公开(公告)号：US06956109B1
公开(公告)日：2005-10-18
申请号：US10031692
申请日：2000-07-21
申请人： Bruno Macchia , Aldo Balsamo , Marco Macchia , Mario Del Tacca , Romano Danesi
发明人： Bruno Macchia , Aldo Balsamo , Marco Macchia , Mario Del Tacca , Romano Danesi
IPC分类号： A61K31/513 , A61K31/7068 , A61P35/00 , C07D239/54 , C07D239/56 , C07H15/26 , C07G11/00 , C07G3/00 , C07H15/00 , C07H17/00
CPC分类号： C07D239/54 , C07D239/56 , C07H15/26
摘要： The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.
摘要翻译： 本发明涉及通式（I）的神经酰胺类似物化合物，其用于制备和用于制备用于治疗肿瘤的药物制剂的方法。
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公开(公告)号：US20050020533A1
公开(公告)日：2005-01-27
申请号：US10919867
申请日：2004-08-17
申请人： Bruno Macchia , Aldo Balsamo , Marco Macchia , Mario Del Tacca , Romano Danesi
发明人： Bruno Macchia , Aldo Balsamo , Marco Macchia , Mario Del Tacca , Romano Danesi
IPC分类号： A61K31/513 , A61K31/7068 , A61P35/00 , C07D239/54 , C07D239/56 , C07H15/26 , C07H19/048 , A61K31/7072
CPC分类号： C07D239/54 , C07D239/56 , C07H15/26
摘要： The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.
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3.发明授权Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions 失效香叶基香叶基香叶基衍生物，其制备方法和相关的药物组合物公开(公告)号：US06242433B1
公开(公告)日：2001-06-05
申请号：US09077196
申请日：1998-09-15
申请人： Aldo Balsamo , Bruno Macchia , Marco Macchia , Massimo Baldacci , Romano Danesi , Mario Del Tacca
发明人： Aldo Balsamo , Bruno Macchia , Marco Macchia , Massimo Baldacci , Romano Danesi , Mario Del Tacca
IPC分类号： A61K31664
CPC分类号： C07F9/3808 , C07C307/04 , C07C307/06 , C07F9/3821 , C07F9/3826 , C07F9/4006
摘要： The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the inhibition of protein geranygeranylation. The invention also relates to the pharmaceutical compositions containing the novel derivatives and to the process of preparation thereof.
摘要翻译： 本发明涉及新颖的香叶基香叶基香叶基衍生物及其在真核细胞中具有抗增殖活性的药学上可接受的盐，涉及抑制蛋白质龙胆神经酰化。 本发明还涉及含有新衍生物的药物组合物及其制备方法。
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4.发明授权Ceramide analogs, process for their preparation and their use as antitumor agents 失效神经酰胺类似物，其制备方法及其作为抗肿瘤剂的用途公开(公告)号：US07214794B2
公开(公告)日：2007-05-08
申请号：US10919867
申请日：2004-08-17
申请人： Bruno Macchia , Aldo Balsamo , Marco Macchia , Mario Del Tacca , Romano Danesi
发明人： Bruno Macchia , Aldo Balsamo , Marco Macchia , Mario Del Tacca , Romano Danesi
IPC分类号： C07D293/10 , A01N43/04 , A61K31/70
CPC分类号： C07D239/54 , C07D239/56 , C07H15/26
摘要： The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors
摘要翻译： 本发明涉及通式（I）的神经酰胺类似物化合物，其用于制备和用于制备用于治疗肿瘤的药物制剂的方法
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5.发明授权公开(公告)号：US07084117B2
公开(公告)日：2006-08-01
申请号：US10466152
申请日：2002-01-14
IPC分类号： A61K38/31
CPC分类号： A61K31/403 , A61K31/404 , A61K38/31
摘要： The present invention relates to a method of treating vascular proliferation in a patient in need thereof. The method includes the step of administering a therapeutically effective amount of a type-1 somatostatin agonist to said patient.
摘要翻译： 本发明涉及在有需要的患者中治疗血管增生的方法。 该方法包括向所述患者施用治疗有效量的1型生长抑素激动剂的步骤。
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