公开(公告)号：US08263121B2

公开(公告)日：2012-09-11

申请号：US11578450

申请日：2005-04-13

申请人： Masahiko Koike ,  Hiroyoshi Koyama ,  Naoru Hamaguchi

发明人： Masahiko Koike ,  Hiroyoshi Koyama ,  Naoru Hamaguchi

IPC分类号： A61K31/4439 ,  A61K31/155 ,  A61K9/201

CPC分类号： A61K9/209 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/155 ,  A61K31/4439 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides a solid preparation containing an insulin sensitizer and an active ingredient (except insulin sensitizers), which shows in vivo dissolution behavior of an insulin sensitizer, which is similar to the dissolution behavior of an insulin sensitizer from “a solid preparation containing an insulin sensitizer alone as an active ingredient”.The present invention provides a solid preparation containing (1) a layer containing an insulin sensitizer, and (2) a layer containing (a) an active ingredient (except insulin sensitizers), (b) microcrystalline cellulose having a mean particle size of 5-25 μm, (c) microcrystalline cellulose having a mean particle size of 30-100 μm and (d) polyvinylpyrrolidone K-90.

摘要翻译： 本发明提供了含有胰岛素敏化剂和活性成分（胰岛素敏化剂除外）的固体制剂，其显示胰岛素敏化剂的体内溶出行为，其类似于胰岛素敏化剂从“含有 单独的胰岛素敏化剂作为活性成分“。 本发明提供一种固体制剂，其含有（1）含有胰岛素敏化剂的层，和（2）含有（a）活性成分（胰岛素敏化剂除外）的层，（b）平均粒径为5〜 25μm，（c）平均粒径为30-100μm的微晶纤维素和（d）聚乙烯吡咯烷酮K-90。