公开(公告)号：US5669376A

公开(公告)日：1997-09-23

申请号：US620615

申请日：1996-03-22

申请人： Constantinos Sioutas

发明人： Constantinos Sioutas

IPC分类号： A61M15/00 ,  A61M11/26 ,  B65D83/14

CPC分类号： A61M15/0086 ,  A61M15/009

摘要： An actuator for use in inhalation therapy comprising a nozzle .block having an orifice and at least one bleed hole, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulation. This invention also provides an actuator as described above in combination with an aerosol canister comprising a pharmaceutical formulation, and a method of administering a pharmaceutical formulation via inhalation therapy. The actuator finds particular use in improving the respirable fraction of drug in aerosol formulations. The actuator also retains non-respirable particles, thus reducing the amount of drug that is inadvertently administered orally.

摘要翻译： 一种用于吸入治疗的致动器，包括具有孔口和至少一个排放孔的喷嘴块，解聚集室和出口室，一起配置为用于增加气溶胶制剂的可呼吸部分的装置。 本发明还提供了如上所述的致动器，其与包含药物制剂的气溶胶罐组合，以及通过吸入治疗施用药物制剂的方法。 致动器特别用于改善气溶胶制剂中药物的呼吸分数。 致动器还保留不可呼吸的颗粒，因此减少了无意中口服给药的药物的量。