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公开(公告)号：US20060171844A1
公开(公告)日：2006-08-03
申请号：US11343787
申请日：2006-01-30
申请人： Constantinos Sioutas , Philip Fine
发明人： Constantinos Sioutas , Philip Fine
IPC分类号： G01N33/00
CPC分类号： G01N15/0255 , H01J49/0031 , H01J49/0468
摘要： Particle detection using a system that enlarges particles, concentrates them, and then dries them to return them to their original sizes. Semiconductor components may be used to maintain better control over the process.
摘要翻译： 使用放大粒子的系统进行粒子检测，浓缩它们，然后将其干燥，使其恢复原始尺寸。 可以使用半导体部件来保持对该过程的更好的控制。
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2.发明申请Particle matter sampling method and sampler with a virtual impactor particle concentrator 有权具有虚拟冲击粒子聚光器的粒子取样方法和采样器公开(公告)号：US20060169065A1
公开(公告)日：2006-08-03
申请号：US11049303
申请日：2005-02-03
申请人： Paul Solomon , Constantinos Sioutas
发明人： Paul Solomon , Constantinos Sioutas
IPC分类号： G01N1/00
CPC分类号： G01N15/0255 , G01N15/0272 , G01N2015/0261
摘要： An apparatus for sampling ambient air to obtain coarse and fine fractions of particulate matter includes a single acceleration tube and a collection tube coaxially arranged along a central axis with a gap between facing distal ends thereof within a range of d/D1 of 1 to 2, wherein d is the distance or gap between the distal ends and D1 is the inside diameter of the outlet at the distal end of the acceleration tube. A housing surrounding the acceleration and concentration tubes is provided with a side-wall nozzle connected to a suction device for drawing a major portion of the sampled ambient air therethrough and for separation of particulate matter, as a fine fraction, from that major portion. A second suction device draws a minor portion of the sampled ambient air, containing the coarse fraction of the particulate matter, in a straight path approximating the central axis, through the acceleration tube and through the collection tube for passage through a filter for separation of the coarse fraction of particulate matter. The ratio of the flow rates of the major and minor portions of the sampled ambient air is adjusted to provide a cutpoint within the range of 2-3 microns. The apparatus is preferably operated with a flow rate for the sampled ambient air within the range of 900-1200 liters per minute.
摘要翻译： 一种用于取样环境空气以获得颗粒物质的粗细和细分的装置包括单个加速管和收集管，该加速管和收集管沿着中心轴同轴地布置，其相对的远端之间的间隙在d / D 1为1至2的范围内 其中d是远端之间的距离或间隙，D 1是加速管远端处出口的内径。 围绕加速度和浓缩管的壳体设置有连接到抽吸装置的侧壁喷嘴，用于抽取大部分采样的环境空气通过其中并用于从该主要部分分离作为细小部分的颗粒物质。 第二抽吸装置将包含粗颗粒物质的少部分采样环境空气沿近似于中心轴线的直线路径通过加速管并通过收集管通过过滤器，以分离 颗粒物的粗分数。 调整采样环境空气的主要部分和次要部分的流量比，以提供2-3微米范围内的切割点。 该装置优选以900-1200升/分钟范围内的采样环境空气的流量进行操作。
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3.发明授权公开(公告)号：US06585803B1
公开(公告)日：2003-07-01
申请号：US09569351
申请日：2000-05-11
IPC分类号： B03C347
CPC分类号： B03C3/155 , B03C3/41 , B03C3/51 , B03C2201/10
摘要： A sintered stainless steel filter is used as the grounded electrode of a point-to-plane electrostatic precipitator. Particles flow through, rather than parallel to, the collection plate. Particle collection efficiency is empirically shown to increase as the charged particles are drawn closer to the grounded filter. The utilization of stainless steel fiber filter provides (1) low particle penetration (high particle collection efficiency) of different particle range, (2) applicability to all different particulate components, (3) high loading capacity but low pressure drop (less energy and maintenance needed), (5) low electric voltage for operating the system, and (6) low cost and small dimension.
摘要翻译： 使用烧结不锈钢过滤器作为点到平面静电除尘器的接地电极。 颗粒流过，而不是平行于收集板。 经验显示，随着带电粒子被拉近，接地过滤器的粒子收集效率会增加。 不锈钢纤维过滤器的使用提供了（1）不同粒子范围的低颗粒渗透（高颗粒收集效率），（2）适用于所有不同颗粒组分，（3）高负载能力但低压降（较少的能量和维护 需要），（5）操作系统的低电压，（6）成本低，尺寸小。
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公开(公告)号：US5571945A
公开(公告)日：1996-11-05
申请号：US403321
申请日：1995-03-13
CPC分类号： G01N15/0618
摘要： Apparatus for measuring the amount of particulate matter in a gas having a gas supply, a first particulate matter collector downstream of the gas supply and in gaseous communication with the gas supply, and a second particulate matter collector downstream of the gas supply and in gaseous communication with the gas supply. Gas from the gas supply to the second particular matter collector is passed through a particle remover to remove particulate matter prior to contact of gas from the gas supply with the second particulate matter collector. A pressure sensor is provided to measure differential pressure between the first particulate matter collector and the second particulate matter collector, and at least one pump to cause gas to pass from the gas supply to the first particulate matter collector and the second particulate matter collector.
摘要翻译： 用于测量具有气体供应的气体中的颗粒物质的量的装置，在气体供应器下游并与气体供应气体连通的第一颗粒物质收集器，以及在气体供应器和气体通路下游的第二颗粒物质收集器 与气体供应。 在气体供应与第二颗粒物收集器接触之前，从气体供应到第二特定物质收集器的气体通过颗粒去除器去除颗粒物质。 提供压力传感器来测量第一颗粒物质收集器和第二颗粒物质收集器之间的压差，以及至少一个泵，以使气体从气体供应通过到第一颗粒物质收集器和第二颗粒物质收集器。
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公开(公告)号：US5115803A
公开(公告)日：1992-05-26
申请号：US575971
申请日：1990-08-31
申请人： Constantinos Sioutas
发明人： Constantinos Sioutas
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0086
摘要： An actuator for use in inhalation therapy comprising a nozzle block having an orifice and at least one bleed hole, a conduit chamber, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulation. This invention also provides an actuator as described above in combination with an aerosol canister comprising a pharmaceutical formulation, and a method of administering a pharmaceutical formulation via inhalation therapy. The actuator finds particular use in improving the respirable fraction of drug in aerosol formulations. The actuator also retains non-respirable particles, thus reducing the amount of drug that is inadvertently administered orally.
摘要翻译： 一种用于吸入治疗的致动器，包括具有孔口和至少一个排放孔的喷嘴块，导管腔室，解聚集室和出口室，一起配置为用于增加气溶胶制剂的可呼吸部分的装置。 本发明还提供了如上所述的致动器，其与包含药物制剂的气溶胶罐组合，以及通过吸入治疗施用药物制剂的方法。 致动器特别用于改善气溶胶制剂中药物的呼吸分数。 致动器还保留不可呼吸的颗粒，因此减少了无意中口服给药的药物的量。
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6.发明授权Particle matter sampling method and sampler with a virtual impactor particle concentrator 有权具有虚拟冲击粒子聚光器的粒子取样方法和采样器公开(公告)号：US07325465B2
公开(公告)日：2008-02-05
申请号：US11049303
申请日：2005-02-03
IPC分类号： G01N1/22
CPC分类号： G01N15/0255 , G01N15/0272 , G01N2015/0261
摘要： An apparatus for sampling ambient air to obtain coarse and fine fractions of particulate matter includes a single acceleration tube and a collection tube coaxially arranged along a central axis with a gap between facing distal ends thereof within a range of d/D1 of 1 to 2, wherein d is the distance or gap between the distal ends and D1 is the inside diameter of the outlet at the distal end of the acceleration tube. A housing surrounding the acceleration and concentration tubes is provided with a side-wall nozzle connected to a suction device for drawing a major portion of the sampled ambient air therethrough and for separation of particulate matter, as a fine fraction, from that major portion. A second suction device draws a minor portion of the sampled ambient air, containing the coarse fraction of the particulate matter, in a straight path approximating the central axis, through the acceleration tube and through the collection tube for passage through a filter for separation of the coarse fraction of particulate matter. The ratio of the flow rates of the major and minor portions of the sampled ambient air is adjusted to provide a cutpoint within the range of 2-3 microns. The apparatus is preferably operated with a flow rate for the sampled ambient air within the range of 900-1200 liters per minute.
摘要翻译： 一种用于取样环境空气以获得颗粒物质的粗细和细分的装置包括单个加速管和收集管，该加速管和收集管沿着中心轴同轴布置，其相对的远端之间的间隙在d / D 1为1至2的范围内 其中d是远端之间的距离或间隙，D 1是加速管远端处出口的内径。 围绕加速度和浓缩管的壳体设置有连接到抽吸装置的侧壁喷嘴，用于抽取大部分采样的环境空气通过其中并用于从该主要部分分离作为细小部分的颗粒物质。 第二抽吸装置将包含粗颗粒物质的少部分采样环境空气沿近似于中心轴线的直线路径通过加速管并通过收集管通过过滤器，以分离 颗粒物的粗分数。 调整采样环境空气的主要部分和次要部分的流量比，以提供2-3微米范围内的切割点。 该装置优选以900-1200升/分钟范围内的采样环境空气的流量进行操作。
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公开(公告)号：US5899201A
公开(公告)日：1999-05-04
申请号：US67221
申请日：1993-05-26
CPC分类号： A61M15/0086 , A61M11/002 , A61M15/009 , A61M15/0065 , A61M2202/064
摘要： A hand held aerosol actuator involving an aerosol source and a chamber having walls defining a constriction aperture. The aerosol source communicates with the chamber and directs an aerosol dose along an axis into the chamber. The constriction aperture is coaxial with the exit orifice and is dimensioned such that the respirable mass of the aerosol dose is increased relative to the respirable mass of an aerosol dose expelled through a like actuator not having the constriction aperture.
摘要翻译： 涉及气溶胶源的手持气溶胶致动器和具有限定收缩孔的壁的室。 气溶胶源与腔室连通并沿着轴线引导气溶胶剂量进入腔室。 收缩孔与出口孔同轴并且尺寸使得气雾剂剂量的可呼吸质量相对于通过不具有收缩孔径的类似致动器排出的气溶胶剂量的可呼吸质量而增加。
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8.发明授权
公开(公告)号：US5669376A
公开(公告)日：1997-09-23
申请号：US620615
申请日：1996-03-22
申请人： Constantinos Sioutas
发明人： Constantinos Sioutas
CPC分类号： A61M15/0086 , A61M15/009
摘要： An actuator for use in inhalation therapy comprising a nozzle .block having an orifice and at least one bleed hole, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulation. This invention also provides an actuator as described above in combination with an aerosol canister comprising a pharmaceutical formulation, and a method of administering a pharmaceutical formulation via inhalation therapy. The actuator finds particular use in improving the respirable fraction of drug in aerosol formulations. The actuator also retains non-respirable particles, thus reducing the amount of drug that is inadvertently administered orally.
摘要翻译： 一种用于吸入治疗的致动器，包括具有孔口和至少一个排放孔的喷嘴块，解聚集室和出口室，一起配置为用于增加气溶胶制剂的可呼吸部分的装置。 本发明还提供了如上所述的致动器，其与包含药物制剂的气溶胶罐组合，以及通过吸入治疗施用药物制剂的方法。 致动器特别用于改善气溶胶制剂中药物的呼吸分数。 致动器还保留不可呼吸的颗粒，因此减少了无意中口服给药的药物的量。
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公开(公告)号：US06990846B2
公开(公告)日：2006-01-31
申请号：US10268114
申请日：2002-10-07
申请人： Constantinos Sioutas
发明人： Constantinos Sioutas
IPC分类号： G01N15/00
CPC分类号： G01N15/0255 , G01G17/04 , G01N1/2208 , G01N15/0205 , G01N2015/0088 , G01N2015/0261 , G01N2015/0288
摘要： An impactor inlet for a system for monitoring an aerosol including a plurality of particles is provided. Each of the particles has a size. The inlet includes a housing defining a chamber to receive and direct a flow of the aerosol. A high flow rate nozzle receives the aerosol at a flow rate of greater than 20 liters per minute (lpm) and accelerates and directs the aerosol flow toward a impaction plate. The aerosol flow separates into a minor flow including particles having a size greater than about 10 um, and a major flow including the remaining particles. The minor flow impacts on the impaction plate, and the major flow is emitted from an outlet.
摘要翻译： 提供了一种用于监测包括多个颗粒的气溶胶的系统的冲击器入口。 每个颗粒都有一个大小。 入口包括限定室以容纳和引导气溶胶流的壳体。 高流量喷嘴以大于20升/分钟（lpm）的流速接收气溶胶，并加速并引导气溶胶流向冲击板。 气溶胶流分离成包含尺寸大于约10μm的颗粒的微流，以及包含剩余颗粒的主流。 小流量冲击撞击板，主流从出口排出。
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公开(公告)号：US06829919B2
公开(公告)日：2004-12-14
申请号：US09992544
申请日：2001-11-13
IPC分类号： G01N1500
CPC分类号： G01N15/0255 , G01G17/04 , G01N1/2208 , G01N15/0205 , G01N2015/0088 , G01N2015/0261 , G01N2015/0288
摘要： A system for monitoring an aerosol including a plurality of particles is provided. Each of the particles has a size. The system includes an impactor assembly to receive the aerosol at a first flow rate and remove an exhaust portion of the particles that are less than a minimum particle size or greater than a maximum particle size. A remaining portion of the particles is emitted at a second flow rate lower than the first flow rate. A first sensor measures a characteristic of the remaining portion of the particles.
摘要翻译： 提供一种用于监测包括多个颗粒的气溶胶的系统。 每个颗粒都有一个大小。 该系统包括以第一流速接收气溶胶的冲击器组件，并且移除小于最小粒径或大于最大粒径的颗粒的排气部分。 颗粒的剩余部分以低于第一流速的第二流量发射。 第一传感器测量颗粒的剩余部分的特性。
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