公开(公告)号：US06706751B2

公开(公告)日：2004-03-16

申请号：US10014959

申请日：2001-12-11

申请人： Johannes Aebi ,  Jean Ackermann ,  Alexander Chucholowski ,  Henrietta Dehmlow ,  Olivier Morand ,  Sabine Wallbaum ,  Thomas Weller ,  Narendra Panday

发明人： Johannes Aebi ,  Jean Ackermann ,  Alexander Chucholowski ,  Henrietta Dehmlow ,  Olivier Morand ,  Sabine Wallbaum ,  Thomas Weller ,  Narendra Panday

IPC分类号： A61P4300

CPC分类号： C07D215/20 ,  C07D209/08

摘要： The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

摘要翻译： 本发明涉及新的二氢吲哚和四氢喹啉衍生物及其药学上可接受的盐和/或其药学上可接受的酯。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。

公开(公告)号：US06759538B2

公开(公告)日：2004-07-06

申请号：US10286017

申请日：2002-11-01

申请人： Rajinder Singh ,  Dane Goff ,  Henry Lu ,  Sarkiz D. Issankani ,  Thomas Sun

发明人： Rajinder Singh ,  Dane Goff ,  Henry Lu ,  Sarkiz D. Issankani ,  Thomas Sun

IPC分类号： A61P4300

CPC分类号： C07D271/06 ,  C07D261/08

摘要： The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.

公开(公告)号：US06720320B2

公开(公告)日：2004-04-13

申请号：US09990389

申请日：2001-11-23

申请人： Akira Nishiyama ,  Masahiro Bougauchi ,  Takanobu Kuroita ,  Masanori Minoguchi ,  Yasunori Morio ,  Kouji Kanzaki

发明人： Akira Nishiyama ,  Masahiro Bougauchi ,  Takanobu Kuroita ,  Masanori Minoguchi ,  Yasunori Morio ,  Kouji Kanzaki

IPC分类号： A61P4300

CPC分类号： C07D413/14 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D491/10

摘要： The present invention relates to a phenoxypropylamine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof or a pharmaceutically acceptable salt thereof and hydrates thereof, which simultaneously show selective affinity for and antagonistic activity against 5-HT1A receptor, as well as 5-HT reuptake inhibitory activity, and can be used as antidepressants quick in expressing an anti-depressive effect.

摘要翻译： 本发明涉及式（I）的苯氧基丙胺化合物，其中每个符号如说明书中所定义，其光学活性化合物或其药学上可接受的盐及其水合物，其同时显示出对5的选择性亲和力和拮抗活性 -HT1A受体，以及5-HT再摄取抑制活性，可用作快速表达抗抑郁作用的抗抑郁药。

公开(公告)号：US06706716B2

公开(公告)日：2004-03-16

申请号：US09764710

申请日：2001-01-17

申请人： Michael Konkel ,  John M. Wetzel ,  Stewart A. Noble ,  Charles Gluchowski ,  Douglas A. Craig

发明人： Michael Konkel ,  John M. Wetzel ,  Stewart A. Noble ,  Charles Gluchowski ,  Douglas A. Craig

IPC分类号： A61P4300

CPC分类号： A61K31/495 ,  A61K31/00 ,  A61K31/4747 ,  A61K31/496

摘要： This invention is directed towards a method of inhibiting activation of a human &agr;1d adrenergic receptor which comprises contacting the receptor with a compound so as to inhibit activation of the receptor, wherein the compound binds selectively to a human &agr;1d adrenergic receptor. This invention provides for a compound which binds selectively to a human &agr;1d adrenergic receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier. This invention further provides for a method of treating a subject afflicted with a disease which is susceptible to treatment by antagonism of the human &agr;1d adrenergic receptor which comprises administering to the subject an amount of the above defined compounds effective to treat the disease.

摘要翻译： 本发明涉及抑制人α1肾上腺素能受体激活的方法，其包括使受体与化合物接触以抑制受体活化，其中所述化合物选择性结合人α1肾上腺素能受体。 本发明提供了选择性结合人α1肾上腺素能受体的化合物。 本发明还提供了包含治疗有效量的上述化合物和药学上可接受的载体的药物组合物。 本发明进一步提供了一种治疗患有易受α1肾上腺素能受体拮抗作用治疗的疾病的受试者的方法，其包括向受试者施用一定量的有效治疗疾病的上述定义的化合物。