公开(公告)号：US06359167B2

公开(公告)日：2002-03-19

申请号：US09725603

申请日：2000-11-29

申请人： Eric J. Toone ,  Jonathan S. Stamler

发明人： Eric J. Toone ,  Jonathan S. Stamler

IPC分类号： C07C32303

CPC分类号： A61L2/23 ,  A61L2/20 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/216 ,  C07C381/00

摘要： Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.

公开(公告)号：US06583311B2

公开(公告)日：2003-06-24

申请号：US10217580

申请日：2002-08-12

申请人： Eric J. Toone ,  Jonathan S. Stamler

发明人： Eric J. Toone ,  Jonathan S. Stamler

IPC分类号： C07C32303

CPC分类号： A61L2/23 ,  A61L2/20 ,  A61L29/16 ,  A61L2300/114 ,  A61L2300/216 ,  C07C381/00

摘要： Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.