公开(公告)号：US06586628B2

公开(公告)日：2003-07-01

申请号：US10075418

申请日：2002-02-14

申请人： Thomas P. Abbott ,  Alan Wohlman

发明人： Thomas P. Abbott ,  Alan Wohlman

IPC分类号： C07C33500

CPC分类号： A61K8/46 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  B05D3/007 ,  B05D3/12 ,  C11B5/0042

摘要： 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.

摘要翻译： 提供1-（3-甲氧基苄基）-3-取代的硫脲抗氧化剂化合物和改进的脂质组合物，其补充了一些有效增强基础脂质的氧化稳定性的抗氧化剂化合物。 还提供了用于增强脂质的氧化稳定性的方法，其包括用至少一种本发明的1-（3-甲氧基苄基）-3-取代的硫脲化合物补充需要增强氧化稳定性的基础脂质。

公开(公告)号：US06794541B2

公开(公告)日：2004-09-21

申请号：US09957530

申请日：2001-09-19

申请人： Zhaohai Zhu ,  Chen Mao ,  Rama K. Narla ,  Fatih M. Uckun

发明人： Zhaohai Zhu ,  Chen Mao ,  Rama K. Narla ,  Fatih M. Uckun

IPC分类号： C07C33500

CPC分类号： G01N33/5011 ,  C07C275/24 ,  C07C335/12 ,  C07C335/14 ,  C07C2602/08 ,  C40B40/00 ,  G01N2510/00

摘要： This invention provides combinatorial chemistry libraries containing thiourea and urea compounds. In addition, the invention relates to methods for constructing combinatorial chemistry libraries containing thiourea and urea compounds. Furthermore, this invention relates to methods for the identification of bioactive thiourea and urea compounds as well as compositions and therapeutic methods for treating cancer.

摘要翻译： 本发明提供了含有硫脲和脲化合物的组合化学文库。 此外，本发明涉及构建含硫脲和脲化合物的组合化学文库的方法。 此外，本发明涉及用于鉴定生物活性硫脲和尿素化合物的方法以及用于治疗癌症的组合物和治疗方法。

公开(公告)号：US06653505B2

公开(公告)日：2003-11-25

申请号：US09840768

申请日：2001-04-23

申请人： Thomas P. Abbott ,  Alan Wohlman

发明人： Thomas P. Abbott ,  Alan Wohlman

IPC分类号： C07C33500

CPC分类号： C11B5/0042 ,  A61K8/46 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00

摘要： 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.