公开(公告)号：US06797709B2

公开(公告)日：2004-09-28

申请号：US10426884

申请日：2003-05-01

申请人： Koichiro Yamada ,  Kenji Matsuki ,  Kenji Omori ,  Kohei Kikkawa

发明人： Koichiro Yamada ,  Kenji Matsuki ,  Kenji Omori ,  Kohei Kikkawa

IPC分类号： C07D24110

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07F9/6512 ,  C07F9/65583

摘要： An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lower alkyl group, —NH—Q—R3 (R3 is a substituted or unsubstituted nitrogen containing heterocyclic group, and Q is a lower alkylene group or a single bond), or —NH—R4 (R4 is a substituted or unsubstituted cycloalkyl group); R2 is a substituted or unsubstituted aryl group; one of Y and Z is ═CH—, and the other is ═N—, or a pharmaceutically acceptable salt thereof, these compounds exhibiting excellent selective PDE V inhibitory activities, and hence, being useful in the prophylaxis or treatment of penile erectile dysfunction, etc.

摘要翻译： 式（I）的芳香族含氮6元环状化合物：其中环A是取代或未取代的含氮杂环基; R 1是取代或未取代的低级烷基，-NH-QR 3（R 3是取代或未取代的含氮杂环基，Q是低级亚烷基或单键）或 - NH-R 4（R 4是取代或未取代的环烷基）; R 2是取代或未取代的芳基; Y和Z之一是= CH-，另一个是= N-或其药学上可接受的盐，这些化合物表现出优异的选择性PDE V抑制活性，因此可用于预防或治疗阴茎勃起功能障碍， 等等