公开(公告)号：US07226926B2

公开(公告)日：2007-06-05

申请号：US10515165

申请日：2003-05-23

申请人： Wesley Peter Blackaby ,  Jose Luis Castro Pineiro ,  Simon Charles Goodacre ,  David James Hallett ,  Alexander Charles Humphries ,  Philip Jones ,  Kevin John Merchant ,  Michael Reader

发明人： Wesley Peter Blackaby ,  Jose Luis Castro Pineiro ,  Simon Charles Goodacre ,  David James Hallett ,  Alexander Charles Humphries ,  Philip Jones ,  Kevin John Merchant ,  Michael Reader

IPC分类号： A61K31/437 ,  A61K31/506 ,  C07D544/294 ,  C07D546/121

CPC分类号： C07D471/04

摘要： A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

摘要翻译： 一类由任选取代的五元或六元杂芳环在3-位被取代的8-氟咪唑并[1,2-α]吡啶衍生物，是GABA A A受体的选择性配体 特别是对α2和/或α3和/或α5亚基具有高亲和力，因此有益于治疗和/或预防中枢神经系统的不利条件，包括焦虑，抽搐和认知障碍。