公开(公告)号：US06531582B1

公开(公告)日：2003-03-11

申请号：US09995617

申请日：2001-11-29

申请人： Joon Shik Shin ,  Sang Tae Kim ,  Yong Nam Han

发明人： Joon Shik Shin ,  Sang Tae Kim ,  Yong Nam Han

IPC分类号： C07H1506

CPC分类号： C07H15/10 ,  A61K31/56 ,  A61K31/70 ,  A61K31/7032 ,  A61K2300/00

摘要： The present invention relates to the novel compound 2-O-(9z,12z-octadecadienoyl)-3-O-[&agr;-D-galactopyranosyl-(1″-6′)-O-&agr;-D-galactopyranosyl]glycerol (Generic name: shinbarometin) having the chemical structure represented by the following formula: or its acetate having an excellent effect on arthritis, osteoporosis and ruptured disc, and to a pharmaceutical composition containing said compound as an effective component, in combination with a pharmaceutically acceptable auxiliary, diluent, isotonic agent, preservative, lubricant and solubilizing aid, which is formulated in the form of a pharmaceutically acceptable preparation and has a potent effect for osteoporosis, arthritis and ruptured disc.

摘要翻译： 本发明涉及新的化合物2-O-（9z，12z-十八碳二烯酰基）-3-O- [α-D-吡喃半乳糖基 - （1“-6'）-O-α-D-吡喃半乳糖基]甘油 具有由下式表示的化学结构的通用名称：新巴斯夫定）或其对关节炎，骨质疏松症和破裂性椎间盘具有优异作用的乙酸酯以及含有所述化合物作为有效成分的药物组合物与药学上可接受的助剂 ，稀释剂，等渗剂，防腐剂，润滑剂和增溶助剂，其以药学上可接受的制剂的形式配制，并且对骨质疏松症，关节炎和破裂的椎间盘具有有效的作用。

公开(公告)号：US06610835B1

公开(公告)日：2003-08-26

申请号：US09249211

申请日：1999-02-12

申请人： Dennis C. Liotta ,  Alfred H. Merrill, Jr. ,  Thomas E. Keane ,  Kapil N. Bhalla ,  Eva M Schmelz

发明人： Dennis C. Liotta ,  Alfred H. Merrill, Jr. ,  Thomas E. Keane ,  Kapil N. Bhalla ,  Eva M Schmelz

IPC分类号： C07H1506

CPC分类号： C07H15/10 ,  C07F9/091 ,  C07F9/113 ,  C07F9/1411 ,  C07F9/143

摘要： Derivatives of sphingolipids of the formula: are provided wherein the substituents are as defined in the specification and wherein there is at least one R2 substituent in the sphingolipid derivative. The compounds are useful in the treatment of of abnormal cell proliferation, including benign and malignant tumors, the promotion of cell differentiation, the induction of apoptosis, the inhibition of protein kinase C, and the treatment of inflammatory conditions, psoriasis, inflammatory bowel disease as well as proliferation of smooth muscle cells in the course of development of plaques in vascular tissue. The invention also includes a method for triggering the release of cytochrome c from mitochondria that includes administering an effective amount of a sphingolipid or its derivative or prodrug to a host in need thereof. Further, the invention provides a method for treating bacterial infections, including those that influence colon cancer and other disorders of the intestine, that includes administering an effective amount of one of the active compounds identified herein.

摘要翻译： 提供下式的鞘脂的衍生物：其中取代基如说明书中所定义，并且其中在鞘脂衍生物中存在至少一个R 2取代基。 该化合物可用于治疗异常细胞增殖，包括良性和恶性肿瘤，促进细胞分化，诱导凋亡，抑制蛋白激酶C，以及治疗炎性病症，牛皮癣，炎性肠病等 以及在血管组织中斑块发育过程中平滑肌细胞的增殖。 本发明还包括触发从线粒体中释放细胞色素c的方法，其包括向有需要的宿主施用有效量的鞘脂或其衍生物或前药。 此外，本发明提供了治疗细菌感染的方法，包括影响结肠癌和肠其他病症的细菌感染的方法，其包括施用有效量的本文鉴定的一种活性化合物。