公开(公告)号：US07423144B2

公开(公告)日：2008-09-09

申请号：US11137632

申请日：2005-05-25

申请人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

发明人： Prakash Jagtap ,  Csaba Szabo ,  Andrew L. Salzman

IPC分类号： A61K31/7056 ,  A61K31/7076 ,  A61K31/708 ,  C07H16/167 ,  C07H16/173

CPC分类号： C07H19/167 ,  C07D473/34 ,  C07H19/12

摘要： The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

摘要翻译： 本发明涉及嘌呤衍生物; 包含有效量的嘌呤衍生物的组合物; 以及降低动物代谢率的方法，保护动物的心脏免受心脏停搏期间的心肌损伤; 或用于治疗或预防心血管疾病，神经障碍，缺血状况，再灌注损伤，肥胖症，消耗性疾病或糖尿病，包括向有需要的动物施用有效量的嘌呤衍生物。