公开(公告)号：US06552167B1

公开(公告)日：2003-04-22

申请号：US09379297

申请日：1999-08-23

申请人： Keith Rose

发明人： Keith Rose

IPC分类号： C07K107

CPC分类号： C07K1/1077 ,  C08G69/00 ,  C08G69/06 ,  C08G69/10

摘要： Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.