公开(公告)号：US6077667A

公开(公告)日：2000-06-20

申请号：US883616

申请日：1997-06-26

申请人： Allan Bradley ,  Ramiro Ramirez-Solis ,  Pentao Liu ,  Hong Su ,  Binhai Zheng

发明人： Allan Bradley ,  Ramiro Ramirez-Solis ,  Pentao Liu ,  Hong Su ,  Binhai Zheng

IPC分类号： A01K67/027 ,  C12N15/10 ,  C12N15/85 ,  C12N15/90 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/87 ,  C12N1/63

CPC分类号： C12N15/102 ,  A01K67/0275 ,  A01K67/0276 ,  C12N15/8509 ,  C12N15/902 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0306 ,  C12N2800/30

摘要： The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal diseases to be generated.

公开(公告)号：US08048658B2

公开(公告)日：2011-11-01

申请号：US12279300

申请日：2007-02-13

申请人： Anthony Clark ,  Jérôme Maury ,  Mohammad Ali Asadollahi ,  Kasper Møller ,  Jens Nielsen ,  Michel Schalk

发明人： Anthony Clark ,  Jérôme Maury ,  Mohammad Ali Asadollahi ,  Kasper Møller ,  Jens Nielsen ,  Michel Schalk

IPC分类号： C12P5/00 ,  C12N1/19 ,  C12N1/63 ,  C07C403/00

CPC分类号： C12N15/52 ,  C12P23/00

摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.

摘要翻译： 本发明涉及能够产生选择的萜烯的微生物。 微生物表达用于形成异戊二烯单元的异源途径，优选异源萜烯合酶。 以这种方式，可以从微生物的培养基中分离出大量的萜烯。