公开(公告)号：US07132121B2

公开(公告)日：2006-11-07

申请号：US10319877

申请日：2002-12-16

申请人： Sandra Bezemer ,  Leon Gerardus Joseph Frenken ,  Johannes Joseph Wilhelmus de Haard ,  Adrianus Marinus Ledeboer ,  Cornelis Theodorus Verrips

发明人： Sandra Bezemer ,  Leon Gerardus Joseph Frenken ,  Johannes Joseph Wilhelmus de Haard ,  Adrianus Marinus Ledeboer ,  Cornelis Theodorus Verrips

IPC分类号： A23L3/3463 ,  A61K38/16 ,  C07K16/08 ,  C07H21/00 ,  C12N13/03 ,  C12N15/85 ,  C12Q1/70

CPC分类号： C07K16/08 ,  A61K2039/505

摘要： A method of inhibiting viral infection using a monovalent antigen binding protein comprising a single domain binding unit capable of binding to a virus is described. Preferably the protein is a heavy chain variable domain derived from an immunoglobulin naturally devoid of light chains. Food, pharmaceutical and cosmetic products comprising such proteins are also described together with a method for selecting inhibiting proteins from a large population of mainly containing non-inhibiting, but infectious agent binding fragments.