公开(公告)号：US06887675B1

公开(公告)日：2005-05-03

申请号：US09843159

申请日：2001-04-25

申请人： Ying Luo ,  Eva Chan ,  Xiang Xu ,  Betty Huang ,  Valeria Ossovskaya

发明人： Ying Luo ,  Eva Chan ,  Xiang Xu ,  Betty Huang ,  Valeria Ossovskaya

IPC分类号： A61K38/00 ,  C12N9/10 ,  C12N9/12 ,  C07H21/04 ,  C12N9/16 ,  C12O1/44 ,  C12O1/48

CPC分类号： C12N9/1077 ,  A61K38/00 ,  C12N2310/111

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。