公开(公告)号：US6004758A

公开(公告)日：1999-12-21

申请号：US701382

申请日：1996-08-22

申请人： Lennart Olsson ,  Tataina Naranda

发明人： Lennart Olsson ,  Tataina Naranda

IPC分类号： C07K14/62 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C07K14/72 ,  C07K14/74 ,  C12Q21/00

CPC分类号： C07K14/70539 ,  C07K14/62 ,  C07K14/705 ,  C07K14/71 ,  C07K14/7153 ,  C07K14/7155 ,  C07K14/72

摘要： Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance the physiological response of ligand binding to the corresponding receptor. The oligopeptides are used in diagnosis and therapy of diseases that involve inadequate or inappropriate receptor response as well as in the screening of drug candidates that affect surface expression of receptors. Also useful for drug screening is a modified receptor molecule, where the sequence corresponding to the regulatory peptide is modified or deleted.

公开(公告)号：US6037135A

公开(公告)日：2000-03-14

申请号：US159339

申请日：1993-11-29

申请人： Ralph T. Kubo ,  Howard M. Grey ,  Alessandro Sette ,  Esteban Celis

发明人： Ralph T. Kubo ,  Howard M. Grey ,  Alessandro Sette ,  Esteban Celis

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/74 ,  C12Q1/00 ,  C12Q21/00

CPC分类号： C07K14/70539 ,  A61K38/00 ,  A61K39/00

摘要： Methods for making peptides comprising an HLA-A24.1-, HLA-A1-, HLA-A11-, and HLA-A3.2-restricted T cell epitope consisting of about 8-11 amino acid residues, and methods of making a peptide that binds to an HLA-A24.1, HLA-A1, HLA-A11, and HLA-A3.2 molecule at a dissociation constant of less than 500 nM.

摘要翻译： 制备包含由约8-11个氨基酸残基组成的HLA-A24.1-，HLA-A1-，HLA-A11-和HLA-A3.2限制性T细胞表位的肽的方法和制备肽 其以小于500nM的解离常数结合HLA-A24.1，HLA-A1，HLA-A11和HLA-A3.2分子。