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    SOLVENTS, METHODS, AND SYSTEMS FOR ISOLATING BOTANICAL EXTRACTS FROM PLANTS
    1.
    发明申请
    SOLVENTS, METHODS, AND SYSTEMS FOR ISOLATING BOTANICAL EXTRACTS FROM PLANTS 有权

    公开(公告)号：US20230036925A1

    公开(公告)日：2023-02-02

    申请号：US17813706

    申请日：2022-07-20

    申请人： Armand J. Noel

    发明人： Armand J. Noel

    IPC分类号： C07C37/84

    摘要： The present invention provides improved solvents, methods, and systems for isolating purified cannabinoids from various sources. It has been found that C9 to C11 non-aromatic hydrocarbon solvents, and especially n-decane, work surprisingly well for crystallization of cannabinoids such as cannabidiol. Some variations provide a method of isolating cannabinoids from a cannabinoid-containing solution, comprising contacting the solution with a C9-C11 non-aromatic hydrocarbon solvent (e.g., n-decane) at a first temperature, to generate a mixture; cooling the mixture to precipitate cannabinoids; and isolating the precipitated cannabinoids. Other variations provide a method of isolating cannabinoids from a cannabinoid-containing solution, comprising contacting the solution with a C9-C11 non-aromatic hydrocarbon solvent (e.g., n-decane) at a first temperature below the solvent boiling point, to generate a mixture; subjecting the mixture to a second temperature that causes vaporization of the solvent, to precipitate at least some of the cannabinoids; and isolating the precipitated cannabinoids.

    Honokiol Crystal Forms, Amorphous Form And Preparation Thereof
    2.
    发明申请
    Honokiol Crystal Forms, Amorphous Form And Preparation Thereof 有权

    公开(公告)号：US20220204432A1

    公开(公告)日：2022-06-30

    申请号：US17277123

    申请日：2021-01-20

    申请人： Chengdu Jinrui Foundation Biotech Co., Ltd.

    发明人： Haoyu Ye ,  Tianmin Zhu ,  Neng Qiu

    IPC分类号： C07C37/84 ,  A61K9/19 ,  A61K9/127

    摘要： The present invention provides honokiol crystal forms A, B and C and amorphous form and a preparation method thereof, wherein the preparation method comprises dissolving honokiol in n-heptane and standing at room temperature overnight to obtain the separated crystal as honokiol crystal form A; heating the honokiol crystal form A and cooling to room temperature to obtain a solid as honokiol crystal form B; heating the honokiol crystal form A to the molten state and then standing at quenching temperature to obtain the separated crystal as honokiol crystal form C; and adding the honokiol crystal form A with an antisolvent in DMSO/H2O system, and thus obtaining the oily matter as honokiol amorphous form. The honokiol crystal forms A, B and C and the amorphous form of the present invention have the advantages of good solubility, good stability, low hygroscopicity, long-term storage and/or good reproducibility, and are suitable for drug development.

    MANUFACTURE OF BISPHENOL A
    9.
    发明申请
    MANUFACTURE OF BISPHENOL A 审中-公开

    公开(公告)号：US20190315670A1

    公开(公告)日：2019-10-17

    申请号：US16317325

    申请日：2017-07-20

    申请人： SABIC GLOBAL TECHNOLOGIES B.V.

    发明人： Branislav OBRADOVIC

    IPC分类号： C07C37/20 ,  C07C37/84 ,  C07C39/16

    摘要： The invention is directed to a method for the manufacture of bisphenol A, and to bisphenol A/phenol adduct crystals. The method of the invention comprises: a) reacting phenol and acetone in the presence of an acidic catalyst to form a reaction product comprising an initial concentration of bisphenol A and an initial concentration of impurities; b) diluting the reaction product with phenol, water and/or acetone, so as to decrease the impurity concentration to 50% by weight or less of the initial concentration of impurities, and adding bisphenol A to increase the concentration thereof in the reaction product; and thereafter c) crystallising a bisphenol A/phenol adduct from the reaction product to produce a crystallised bisphenol A product.