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公开(公告)号：US20240117142A1
公开(公告)日：2024-04-11
申请号：US18265702
申请日：2021-12-14
申请人： BASF SE
发明人： Caroline BEYER , Florian RICHTER
IPC分类号： C08J11/16 , C07D223/10
CPC分类号： C08J11/16 , C07D223/10 , C08J2375/04 , C08J2377/02 , Y02W30/62
摘要： A process for obtaining caprolactam from mixtures of caprolactam-containing polymers and polyurethane-containing polymers, in particular polyurethane block copolymers, by depolymerization, wherein the depolymerization of the mixture is performed in the presence of 0.05% to 5% by weight of a base at a temperature of 250° C. to 350° C. and a pressure of 5 to 700 mbar and wherein the caprolactam is obtained in gaseous form.
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公开(公告)号：US20230033285A1
公开(公告)日：2023-02-02
申请号：US17842415
申请日：2022-06-16
发明人： Arnab K. Chatterjee , Jian Jeffrey Chen , Elshan Nakath , Alireza Rahimi , Anil Kumar Gupta , Gennadii Grabovyi , Katy Wilson , Sourav Ghorai , Armen Nazarian , James Pedroarena , Wrickban Mazumdar , Frank Weiss , Lirui Song , Malina A. Bakowski , Laura Riva , Karen Wolff , Case W. McNamara , Thomas F. Rogers , Jacqueline Malvin , Shuangwei Li , Sean Joseph , Ashley Woods , Yuyin Liu , Neechi Okwor
IPC分类号： C07D491/048 , C07D403/12 , C07D207/26 , C07D401/12 , C07D211/76 , C07D223/10 , C07D405/14 , C07D413/14 , C07D401/14 , C07D413/12 , A61P31/14
摘要： Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.
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公开(公告)号：US11485725B2
公开(公告)日：2022-11-01
申请号：US16766538
申请日：2018-11-14
申请人： Auransa Inc.
发明人： Andrew Asher Protter , Michael John Green , Hak Jin Chang , Son Minh Pham , Sarvajit Chakravarty , Gregory R. Luedtke , Pek Yee Lum
IPC分类号： C07D401/06 , C07D401/14 , C07D211/86 , C07D211/96 , C07D413/06 , C07D491/056 , C07D405/06 , C07D405/14 , C07D401/12 , C07D401/04 , C07D403/06 , C07D223/10
摘要： The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlongumine; and use of the derivatives and analogs for treating cancer.
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公开(公告)号：US20220001364A1
公开(公告)日：2022-01-06
申请号：US17208535
申请日：2021-03-22
发明人： Shibiao CHENG , Songlin WANG , Fei SHEN , Han WANG , Yixuan HE , Zhaobin JIANG , Zhimin HU
IPC分类号： B01J29/76 , C07D201/04 , B01J29/78 , C01B39/48 , B01J35/02 , B01J21/08 , B01J37/04 , B01J37/08 , C07D223/10 , B01J29/70 , B01J35/10 , B01J37/00 , B01J37/06
摘要： The present disclosure discloses a MFI topological structure silicon molecular sieve, a preparation method thereof and a catalyst containing the MFI topological structure silicon molecular sieve, wherein the molecular sieve containing a silicon element, an oxygen element and a metallic element, the ions of said metallic element have a Lewis acid characteristic; the content of the metallic element in the molecular sieve is within a range of 5-100 μg/g based on the total amount of the molecular sieve; the BET specific surface area of the molecular sieve is within a range of 400-500 m2/g.
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公开(公告)号：US11208380B2
公开(公告)日：2021-12-28
申请号：US17000116
申请日：2020-08-21
申请人： AquafilSLO d.o.o.
发明人： Anacleto Dal Moro , Michele Cecchetto , Denis Jahic , Vid Margon
IPC分类号： B01D3/10 , C07D201/16 , B01D3/14 , B01D11/04 , C07D201/06 , C07D223/10
摘要： The present invention relates to a process for purifying caprolactam from solutions of crude caprolactam by a direct treatment with one or more alkaline compounds of polyvalent metals, preferably bivalent and trivalent, without resorting to organic solvent extraction as used in the usual purification process.
A further subject of the present invention is a facility devoid of a unit for organic solvent extraction and designed to carry out the caprolactam purification process described herein.-
公开(公告)号：US20210206725A1
公开(公告)日：2021-07-08
申请号：US17056705
申请日：2018-05-18
申请人： BioVentures, LLC
发明人： Guangrong Zheng , Daohong Zhou , Xuan Zhang
IPC分类号： C07D223/10 , C07D211/88 , C07D265/02 , A61K45/06
摘要： The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.
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公开(公告)号：US20210171459A1
公开(公告)日：2021-06-10
申请号：US16932405
申请日：2020-07-17
申请人： Genomatica, Inc.
IPC分类号： C07D201/08 , C07D223/10 , C07D201/16 , C08G69/16
摘要： The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.
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公开(公告)号：US10799518B2
公开(公告)日：2020-10-13
申请号：US16566682
申请日：2019-09-10
申请人： Allergan, Inc.
IPC分类号： A61K31/683 , A61P17/08 , A61K31/4725 , A61K31/472 , A61K31/4184 , A61K31/4178 , A61K31/4174 , A61K31/41 , A61K31/4045 , A61K31/192 , A61K31/167 , A61K9/00 , A61K31/662 , A61K31/42 , A61K31/4166 , A61K31/196 , A61K31/17 , A61P17/16 , A61P17/06 , A61P17/14 , A61P17/04 , A61P17/10 , A61P17/18 , A61P35/00 , A61P17/02 , A61P17/12 , C07D409/06 , C07D405/14 , C07D405/06 , C07D401/06 , C07D261/12 , C07D257/04 , C07D235/02 , C07D233/80 , C07D223/10 , C07D217/24 , C07C275/42 , C07C235/82 , C07F9/40 , A61K31/55
摘要： The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).
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公开(公告)号：US20200291436A1
公开(公告)日：2020-09-17
申请号：US16664526
申请日：2019-10-25
申请人： Genomatica, Inc.
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
IPC分类号： C12P13/00 , C07C227/06 , C07D223/10 , C12P13/02 , C07D201/08
摘要： The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing ε-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.
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公开(公告)号：US10434112B2
公开(公告)日：2019-10-08
申请号：US15490127
申请日：2017-04-18
申请人： Allergan, Inc.
IPC分类号： A61K31/195 , A61K31/683 , C07F9/40 , C07C235/82 , C07C275/42 , C07D217/24 , C07D223/10 , C07D233/80 , C07D235/02 , C07D257/04 , C07D261/12 , C07D401/06 , C07D405/06 , C07D405/14 , C07D409/06 , A61P17/12 , A61P17/02 , A61P35/00 , A61P17/18 , A61P17/10 , A61P17/04 , A61P17/14 , A61P17/06 , A61P17/16 , A61K31/17 , A61K31/196 , A61K31/4166 , A61K31/42 , A61K31/662 , A61K9/00 , A61K31/167 , A61K31/192 , A61K31/4045 , A61K31/41 , A61K31/4174 , A61K31/4178 , A61K31/472 , A61K31/4725 , A61K31/55
摘要： The present invention relates to a method for treating dermal inflammation and dermal diseases by local or systemic delivery, in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2 (FPR2).
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