公开(公告)号：US11583612B2

公开(公告)日：2023-02-21

申请号：US16804586

申请日：2020-02-28

申请人： Agency for Science, Technology and Research ,  National University Hospital (Singapore) Pte Ltd ,  National University of Singapore ,  Singapore Health Services Pte Ltd

发明人： Xian Jun Loh ,  Xinyi Su ,  Zengping Liu ,  Gopal Lingam ,  Veluchamy Amutha Barathi ,  Walter Hunziker

IPC分类号： A61L27/18 ,  C08G81/00

摘要： There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.

公开(公告)号：US11571443B2

公开(公告)日：2023-02-07

申请号：US16338330

申请日：2017-09-29

申请人： THE UNIVERSITY OF CHICAGO ,  UCHICAGO ARGONNE, LLC

发明人： John C. Alverdy ,  Matthew Tirrell ,  Olga Y. Zaborina ,  Jun Mao ,  Wei Chen

IPC分类号： A61K31/77 ,  C08G65/335 ,  C08G81/00 ,  A61P31/04 ,  A61P1/00 ,  A61K47/10 ,  A61K47/34 ,  A61K31/765 ,  A61K9/00 ,  A61K31/80

摘要： The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.

公开(公告)号：US11497838B2

公开(公告)日：2022-11-15

申请号：US16914085

申请日：2020-06-26

申请人： W.L. Gore & Associates, Inc.

发明人： Karin Leontein ,  Per Antoni ,  Daniel Nyström ,  Paul Begovac ,  Krzysztof Pietrzak

IPC分类号： A61L33/00 ,  A61P7/02 ,  C08L79/02 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C08G81/00 ,  A61L33/06 ,  A61L33/08

摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

公开(公告)号：US11485852B2

公开(公告)日：2022-11-01

申请号：US16793529

申请日：2020-02-18

申请人： NORTHERN TECHNOLOGIES INTERNATIONAL CORPORATION

发明人： Preetam Giri ,  Shilpa Manjure ,  Sayli Bote

IPC分类号： C08L67/04 ,  B29C48/405 ,  C08L53/00 ,  B29K67/00 ,  C08G77/42 ,  C08G81/00 ,  C08L87/00

摘要： The notched Izod impact toughness and tensile elongation of poly(lactic acid) (PLA)-homopolymers are increased by about 2 to about 4 times by blending therewith a PLA-copolymer having a difunctional flexible middle segment such as a polysiloxane or a polyether from about 0.6 wt. % to about 20 wt. %. The PLA-homopolymer-PLA-copolymer blend having a difunctional flexible polymer from about 0.5 wt. % to about 10 wt. % is thermally annealed to provide impact toughness of at least about 5 kJ/m2 and tensile elongation of greater than 12%. This exceptional improvement observed in the PLA blend is a synergistic effect of the addition of the difunctional flexible polymer of the copolymer and thermal annealing. The improvement observed in the mechanical properties with high PLA homopolymer content above about 90 to about 98 wt. % is unusual and results in an increased scope of molding and thermoforming applications. The annealed PLA-copolymers having a difunctional flexible middle segment have also been found to have improved notched Izod impact properties.

公开(公告)号：US20220340718A1

公开(公告)日：2022-10-27

申请号：US17717041

申请日：2022-04-09

申请人： FUZHOU UNIVERSITY

发明人： Minghua Liu ,  Xiuhua Lin ,  Lihui Chen ,  Yaohua Liu ,  Weilin Wang

IPC分类号： C08G81/00 ,  C08H7/00

摘要： The invention discloses a lignin degradation product-bisphenol A-polyurethane polycondensate additive, and a preparation method thereof. Lignin is used as a raw material, and is degraded by an alkali activator, a metal catalyst and nitrobenzene to obtain the lignin degradation product; then, the obtained lignin degradation product is uniformly mixed with bisphenol A, and polyurethane is added; finally, the additive is obtained after heating reaction and drying. The preparation process of the invention is simple, and the obtained lignin degradation product has a small and stable molecular weight and has abundant phenolic hydroxyl and alcoholic hydroxyl sites, which can improve the dispersibility of the product, with strong cohesiveness and good waterproofness. It solves the problem of industrial application that lignin replaces part of phenols in the prior art, which leads to the decline of product performance, improves the total substitution rate of chemicals derived from biomass to bisphenol A derived from fossil resources, and significantly reducing the discharge of phenolic compounds. The additive is an environment-friendly polymeric material with excellent development potential.

公开(公告)号：US20220325049A1

公开(公告)日：2022-10-13

申请号：US17709606

申请日：2022-03-31

申请人： James R. Glidewell Dental Ceramics, Inc.

发明人： Derek A. Lublin

IPC分类号： C08G81/00 ,  C09D187/00 ,  C08K5/132 ,  B33Y70/00

摘要： A polymeric resin that includes a photocured reaction product of at least one urethane (meth)acrylate polymer that includes at least one polycarbonate unit; at least one monofunctional monomer; and at least one crosslinking agent.

公开(公告)号：US20220296635A1

公开(公告)日：2022-09-22

申请号：US17691518

申请日：2022-03-10

申请人： Board of Regents, The University of Texas System

发明人： Jian Yang

IPC分类号： A61K31/785 ,  A61K31/765 ,  C08G63/12 ,  C08G63/91 ,  C12N5/077 ,  A61K33/42 ,  C08G81/00 ,  C08L67/04

摘要： In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.

公开(公告)号：US11383008B2

公开(公告)日：2022-07-12

申请号：US16312594

申请日：2017-06-23

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite de Montpellier ,  Ecole Nationale Superieure de Chimie de Montpellier—ENSCM

发明人： Benjamin Nottelet ,  Anita Schulz épouse Luxenhofer ,  Jean Coudane

IPC分类号： A61K31/14 ,  A61L31/14 ,  A61L27/34 ,  A61K49/12 ,  A61L31/10 ,  C08G73/06 ,  C08G81/00

摘要： The present invention relates to an efficient method for grafting a properties-imparting compound onto a polymeric substrate containing carbon-hydrogen (C—H) bonds using clip chemistry. The method of the invention includes coating the substrate with the properties-imparting compound and irradiating it with a reactive light source, and repeating this sequence at least once. The present invention further relates to surface-modified polymeric substrates grafted with a properties-imparting compound, in particular obtained with the method of the invention, medical devices comprising same, and non-medical of said surface-modified polymeric substrates.

公开(公告)号：US11235066B2

公开(公告)日：2022-02-01

申请号：US15780277

申请日：2016-12-01

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Thomas D. Wang ,  Supang Khondee

IPC分类号： A61K47/69 ,  C08G69/40 ,  C08G69/10 ,  C08G81/00 ,  A61K9/107 ,  A61K47/62 ,  A61K47/60 ,  A61K47/54 ,  A61P35/00 ,  A61K31/436 ,  C08G65/334

摘要： The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.

公开(公告)号：US20210380764A1

公开(公告)日：2021-12-09

申请号：US17407160

申请日：2021-08-19

申请人： Fudan University ,  Zhuhai Fudan Innovation Institute

发明人： Jiandong Ding ,  Jingyu Tang ,  Dinglingge Cao ,  Lin Yu

IPC分类号： C08G81/00 ,  C08K3/16 ,  C08K3/30 ,  C08K5/098 ,  A61K8/90 ,  A61K47/34 ,  A61K47/02 ,  A61K8/19 ,  A61K8/27

摘要： The present application relates to a polymer composite capable of being quickly dissolved or dispersed in an aqueous solvent, and a preparation method and an application thereof. The polymer composite includes a polymer capable of being thermodynamically dissolved in water or an aqueous solvent and a dispersant containing an ion capable of coordinating with the polymer. The polymer is selected from the group of a water soluble homopolymer and/or copolymer, in particular, thermogelable amphiphilic copolymer.