公开(公告)号：WO2022051060A1

公开(公告)日：2022-03-10

申请号：PCT/US2021/045150

申请日：2021-08-09

Applicant: ORTHOGENRX, INC.

Inventor： MENCEL, James, J. ,  TOLEDO-VELASQUEZ, David ,  DALEY, Michael, Joseph

IPC: A61K9/00 ,  A61K47/36 ,  C08B37/08

Abstract: The present invention provides a non-animal derived, such as non-avian derived hyaluronic acid (HA) that has a molecular weight of about 500 to about 16000 kD, preferably about 500 kDa to about 10000 kDa. Most preferred HAs have a molecular weight of about 3000 kDa to about 6000 kDa. This HA is DVS cross-linked, water soluble and stable over time. The presently provided HA is free from the immunogenic proteins that are found in animal derived HAs. Further, the HAs of the present invention are microbiologically-derived or chemically synthesized, yet cross-linked to remain water soluble and stable over a period of time. Preparation of cross-linked HA' s of the invention using non-animal derived HA avoids the negative immunologic reactions observed for previously described animal derived cross -linked HAs.

公开(公告)号：WO2021126767A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/064855

申请日：2020-12-14

Applicant: ORTHOGENRX, INC.

Inventor： KORNHABER, Gregory, J. ,  TOLEDO-VELAZQUEZ, David

IPC: A61M5/32 ,  A61B17/34 ,  A61M5/178 ,  A61M5/46

Abstract: The present invention relates to a device for measuring, recording, and acting in response to changes in air pressures encountered through the lumen of a connected needle. The device signals when it has been powered and signals when the device recognizes both pressures and pressure change rates indicative of intra-articular or synovial cavity joint penetration, such as knee joint penetration. Synovial cavity pressures detected and acted upon may either be supra- (positive) or sub-atmospheric (negative). Internal light emitting diodes and a laptop connected display are demonstrated as signaling and communication mechanisms. Methods for delivering medicaments into human and animal intra-articular cavities or joints such as synovial cavities are provided. Furthermore, methods for facilitating the diagnoses of joint effusion also are provided.