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公开(公告)号：WO2018213834A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033704
申请日：2018-05-21
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： GERMINARIO, Louis, Thomas , HEBRANK, John, H. , HUNTER, Charles, Eric
IPC: A61M15/00
Abstract: A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 µm, so as to target the pulmonary system of the user.
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公开(公告)号：WO2017192778A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030925
申请日：2017-05-03
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： GERMINARIO, Louis Thomas , HEBRANK, John H. , HUNTER, Charles Eric , STERN, Thomas P.
Abstract: The present disclosure provides system and methods for pulmonary health using one or more inhalation devices. In one aspect, the air inhalation devices each comprise one or more sensors configured to capture pulmonary health data for a patient. Using this data, air analytics may be generated pertaining to individualized patient health, general health for people living within a particular geographical location, air quality for a particular geographical region, operational parameters of the inhalation devices, and/or the like. The air analytics may be output, for example, for display on a user device, such as a patient user device, a health care provider user device, and/or an admintrator user device.
Abstract translation: 本公开提供了使用一个或多个吸入装置用于肺部健康的系统和方法。 在一个方面，空气吸入设备各自包括一个或多个传感器，其被配置为捕获患者的肺部健康数据。 使用这些数据，可以生成关于个体化患者健康，生活在特定地理位置内的人的一般健康，特定地理区域的空气质量，吸入装置的操作参数等的空气分析。 例如，可以输出空气分析以用于显示在诸如患者用户装置，健康护理提供者用户装置和/或admintator用户装置的用户装置上。
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公开(公告)号：WO2019195239A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025321
申请日：2019-04-02
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： HEBRANK, John H. , HUNTER, Charles Eric
Abstract: A handheld digital nebulizer device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The handheld digital nebulizer device includes a housing having an exhalation valve, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The handheld digital nebulizer device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The handheld digital nebulizer device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 µm, so as to target the pulmonary system of the user.
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4.发明申请
公开(公告)号：WO2019136437A1
公开(公告)日：2019-07-11
申请号：PCT/US2019/012691
申请日：2019-01-08
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： HUNTER, Charles Eric , HEBRANK, John H.
Abstract: Methods for the treatment of pulmonary cancers (primary, secondary, metastatic, etc.) using an electronic breath actuated droplet delivery device to deliver a cancer therapeutic directly to the pulmonary system of a subject in need thereof is disclosed. An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 µm, so as to target the pulmonary system of the user.
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5.发明申请
公开(公告)号：WO2019094628A1
公开(公告)日：2019-05-16
申请号：PCT/US2018/059874
申请日：2018-11-08
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： HEBRANK, John H. , MAURER, Christopher W. , HUNTER, Charles Eric , LI, Chengjie , GERMINARIO, Louis Thomas
Abstract: A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 µm, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.
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Patent Agency Ranking6.发明申请SYSTEMS AND METHODS COMPRISING A DROPLET DELIVERY DEVICE AND A BREATHING ASSIST DEVICE FOR THERAPEUTIC TREATMENT 审中-公开包括滴管递送装置和用于治疗处置的呼吸辅助装置的系统和方法
公开(公告)号：WO2017192782A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030929
申请日：2017-05-03
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： GERMINARIO, Louis Thomas , HEBRANK, John H. , HUNTER, Charles Eric , STERN, Thomas P. , HUNTER, Jack C.
Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 µm, so as to target the pulmonary system of the user.
Abstract translation: 公开了用于将精确和可重复的剂量输送到用于肺部使用的受试者的液滴输送装置和相关方法。 液滴输送装置包括壳体，贮存器和排出器机构，以及至少一个差压传感器。 当压差传感器感测到壳体内的预定压力变化时，液滴输送装置自动由使用者呼吸致动。 然后致动液滴输送装置以产生平均喷射液滴直径在可呼吸尺寸范围内（例如小于约5微米）的液滴流，以便瞄准使用者的肺部系统。
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7.发明申请METHODS FOR TREATMENT OF PULMONARY LUNG DISEASES WITH IMPROVED THERAPEUTIC EFFICACY AND IMPROVED DOSE EFFICIENCY 审中-公开提高治疗效率和提高剂量效率治疗肺部疾病的方法
公开(公告)号：WO2017192773A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030919
申请日：2017-05-03
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： GERMINARIO, Louis Thomas , HEBRANK, John H. , HUNTER, Charles Eric , STERN, Thomas P.
Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 µm, so as to target the pulmonary system of the user.
Abstract translation: 公开了用于将精确和可重复的剂量输送到用于肺部使用的受试者的液滴输送装置和相关方法。 液滴输送装置包括壳体，贮存器和排出器机构，以及至少一个差压传感器。 当压差传感器感测到壳体内的预定压力变化时，液滴输送装置自动由使用者呼吸致动。 然后致动液滴输送装置以产生平均喷射液滴直径在可呼吸尺寸范围内（例如小于约5微米）的液滴流，以便瞄准使用者的肺部系统。
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8.发明申请
公开(公告)号：WO2021203038A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/025634
申请日：2021-04-02
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： HUNTER, Charles Eric , CULPEPPER, Matthew
IPC: A61K9/12 , A61K31/704 , A61M15/00 , A61P11/00
Abstract: Methods for delivering a fluid composition comprising at least one ginsenoside as an ejected stream of droplets in a respirable range to the respiratory system of a user are disclosed. The methods are able to deliver the ejected stream of droplets to the respiratory system of the user such that at least about 50% of the mass of the ejected stream of droplets is delivered in a respirable range to the respiratory system of a user during use. The ejected stream of droplets may be generated via an ejector mechanism comprising a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use.
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公开(公告)号：WO2020154497A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/014785
申请日：2020-01-23
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： HUNTER, Charles Eric , HEBRANK, John H.
Abstract: Methods, devices and systems are provided wherein compositions are delivered to the pulmonary system of an intended user via inhalation in a controlled manner and at a desired doses and/or amounts, e.g., within a desired dosage window and/or inhalation topography. In certain embodiments, dosage windows and/or inhalation topography may be used, e.g. , to provide for controlled cessation of use or to provide a desired therapeutic window.
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10.发明申请METHODS FOR GENERATING AND DELIVERING DROPLETS TO THE PULMONARY SYSTEM USING A DROPLET DELIVERY DEVICE 审中-公开使用滴液输送装置产生和输送滴落到肺部系统的方法
公开(公告)号：WO2017192771A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030917
申请日：2017-05-03
Applicant: PNEUMA RESPIRATORY, INC.
Inventor： GERMINARIO, Louis Thomas , HEBRANK, John H. , HUNTER, Charles Eric , HUNTER, Jack C. , LI, Chengjie , MAURER, Christopher W.
Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 µm, so as to target the pulmonary system of the user.
Abstract translation: 公开了用于将精确和可重复的剂量输送到用于肺部使用的受试者的液滴输送装置和相关方法。 液滴输送装置包括壳体，贮存器和排出器机构，以及至少一个差压传感器。 当压差传感器感测到壳体内的预定压力变化时，液滴输送装置自动由使用者呼吸致动。 然后致动液滴输送装置以产生平均喷射液滴直径在可呼吸尺寸范围内（例如小于约5微米）的液滴流，以便瞄准使用者的肺部系统。
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