公开(公告)号：WO2021203038A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/025634

申请日：2021-04-02

Applicant: PNEUMA RESPIRATORY, INC.

Inventor： HUNTER, Charles Eric ,  CULPEPPER, Matthew

IPC: A61K9/12 ,  A61K31/704 ,  A61M15/00 ,  A61P11/00

Abstract: Methods for delivering a fluid composition comprising at least one ginsenoside as an ejected stream of droplets in a respirable range to the respiratory system of a user are disclosed. The methods are able to deliver the ejected stream of droplets to the respiratory system of the user such that at least about 50% of the mass of the ejected stream of droplets is delivered in a respirable range to the respiratory system of a user during use. The ejected stream of droplets may be generated via an ejector mechanism comprising a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use.

公开(公告)号：WO2023091637A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/050361

申请日：2022-11-18

Applicant: PNEUMA RESPIRATORY, INC.

Inventor： HUNTER, Charles Eric ,  SCOGGIN, Michael ,  MILLER, Jeffrey ,  SALAZAR, Jose ,  CULPEPPER, Matthew ,  RAPP, Gregory ,  MODLIN, Caley ,  CLEMENTS, Judson Sidney

IPC: A61M11/00 ,  B05B17/06

Abstract: A droplet delivery device configured for treating eye conditions includes an outlet with an alignment guide for aligning the device to an eye, a fluid reservoir in fluid communication with a membrane and mesh of an ejection generator, and an electronic vibrating member coupled to the membrane to push fluid through the mesh and eject droplets through the outlet to treat an eye.

公开(公告)号：WO2023064477A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/046582

申请日：2022-10-13

Applicant: PNEUMA RESPIRATORY, INC.

Inventor： CULPEPPER, Matthew

IPC: A61K31/352 ,  A61K31/05 ,  A61K31/045 ,  A61K31/35

Abstract: Embodiments of the present disclosure provide compositions and methods for administering cannabinoids to the respiratory system of a subject. Accordingly, embodiments herein include compositions comprising one or more cannabinoids and pharmaceutical compositions comprising one or more cannabinoids. Embodiments herein also include methods of making compositions herein, methods of delivering compositions herein, and methods of treating a subject by administering one or more compositions herein.

公开(公告)号：WO2022271848A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034552

申请日：2022-06-22

Applicant: PNEUMA RESPIRATORY, INC.

Inventor： HUNTER, Charles Eric ,  SCOGGIN, Michael ,  MILLER, Jeffrey ,  SALAZAR, Jose ,  BEACH, Brian ,  MODLIN, Caley ,  CULPEPPER, Matthew ,  LI, Jianqiang ,  LI, Chengjie ,  WANG, Shi Bo ,  LEE, Chao-Ping ,  RAPP, Gregory ,  CLEMENTS, Judson Sidney

IPC: A61M11/00 ,  A61M15/00 ,  A61M15/06 ,  A61M11/003 ,  A61M11/005 ,  A61M15/0001 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0085 ,  A61M2205/8206 ,  A61M2206/11

Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

公开(公告)号：WO2020264501A1

公开(公告)日：2020-12-30

申请号：PCT/US2020/040132

申请日：2020-06-29

Applicant: PNEUMA RESPIRATORY, INC.

Inventor： HEBRANK, John H. ,  HUNTER, Charles Eric ,  CULPEPPER, Matthew

IPC: A61M15/08

Abstract: An ejector mechanism, droplet delivery device and related methods or del verng sma droplets to the respiratory system o a user s disclosed. The ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use. The droplet delivery device is automatically breath actuated by a user when the differential pressure sensor senses a predetermined pressure change. The ejector mechanism is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range having a diameter of less than about 4 um so as to target the respiratory system of the user.