公开(公告)号：WO2015058778A1

公开(公告)日：2015-04-30

申请号：PCT/DK2014/050351

申请日：2014-10-24

Applicant: KØBENHAVNS UNIVERSITET

Inventor： SØRENSEN, Thomas Just ,  ROSENBERG, Martin ,  LAURSEN, Bo W.

IPC: C08L83/06

CPC classification number: C08L83/06 ,  B01L3/5082 ,  C08G77/08 ,  C08G77/14 ,  C08L83/04 ,  C08L2205/02 ,  C09B57/00 ,  C09B68/28 ,  C09B68/4475 ,  C09B69/008 ,  C09B69/109 ,  G01N21/78 ,  G01N21/80 ,  G01N2021/7756 ,  G01N2021/7786

Abstract: The present invention relates to a method for the production of a sol-gel based matrix. The method comprises the steps of: a) providing a first alkoxysilane of the general formula: R 1 -Si(OR 2 ) 3 and a second alkoxysilane of the general formula (I): b) preparing a first sol-gel component by polymerisation of the first alkoxysilane in the presence of an acid catalyst, c) preparing a second sol-gel component by polymerisation of the second alkoxysilane in the presence of an Lewis acid catalyst, d) Mixing the first sol-gel component and the second sol-gel component for the preparation of a sol-gel based matrix. The above method results in a sol-gel based matrix with high stability and high porosity. The sol-gel based material may be used for the production of a composite or sensor suitable for monitoring analytes. Methods for preparing these composites or sensors are provided as well.

Abstract translation: 本发明涉及一种制备基于溶胶 - 凝胶的基质的方法。 该方法包括以下步骤：a）提供通式为：R1-Si（OR2）3的第一烷氧基硅烷和通式（I）的第二烷氧基硅烷：b）通过聚合所述第一溶胶 - 凝胶组分 在酸催化剂的存在下，第一烷氧基硅烷，c）在路易斯酸催化剂存在下，通过第二烷氧基硅烷的聚合制备第二溶胶 - 凝胶组分，d）将第一溶胶 - 凝胶组分和第二溶胶 - 凝胶组分 用于制备基于溶胶 - 凝胶的基质。 上述方法产生具有高稳定性和高孔隙率的溶胶 - 凝胶基质。 基于溶胶 - 凝胶的材料可用于生产适用于监测分析物的复合材料或传感器。 还提供了制备这些复合材料或传感器的方法。

公开(公告)号：WO2020260684A1

公开(公告)日：2020-12-30

申请号：PCT/EP2020/068215

申请日：2020-06-29

Applicant: KØBENHAVNS UNIVERSITET

Inventor： SØRENSEN, Thomas Just

IPC: C09K11/06 ,  G01N21/77 ,  G01N33/58

Abstract: Disclosed herein is sensor for emitting luminescence proportional to the concentration of a target analyte, comprising a luminescent lanthanide entity capable of interacting with a target analyte, wherein the relative luminescence emission intensity of the luminescent lanthanide entity changes, when subjected to an excitation light source, in dependency of the concentration of the target analyte, and a matrix material immobilizing the luminescent lanthanide entity. Also enclosed is a system for measuring a concentration of a target analyte and a composite comprising a layer of matrix material immobilizing a luminescent lanthanide entity and a substrate comprising a microstructure area.

公开(公告)号：WO2015058777A1

公开(公告)日：2015-04-30

申请号：PCT/DK2014/050350

申请日：2014-10-24

Applicant: KØBENHAVNS UNIVERSITET

Inventor： LAURSEN, Bo V. ,  ROSENBERG, Martin ,  SØRENSEN, Thomas Just

IPC: C07D471/14 ,  C07D491/14

CPC classification number: C07D491/16 ,  C07D471/14 ,  C07D471/16 ,  C07D491/14 ,  C07F7/1836 ,  C09B15/00 ,  C09B69/00 ,  C09B69/008 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The present invention relates to a new class of substituted aza-triangulenium fluorescent dyes having a hydroxy group attached to an aryl as quenching group. The new substituted aza-triangulenium fluorescent dyes may be attached to a linker, conjugated to carrier molecule such as e.g. a protein, a nucleic acid, a lipid, or a saccharide, or deposited or immobilised on solid support materials. The substituted aza-triangulenium fluorescent dyes are useful for various purposes, including use in sensors for monitoring or determining the concentration of analytes, such as H + (pH), Na + , K + , Ca 2+ , O 2 , CO 2 , H 2 O 2 , ionic strength, redox potentials, metal ions,and metabolites.

Abstract translation: 本发明涉及一类新的具有连接到芳基作为猝灭基团的羟基的取代的氮杂 - 三联体荧光染料。 新的取代的氮杂三环脲荧光染料可以连接到与载体分子结合的接头上， 蛋白质，核酸，脂质或糖类，或者沉积或固定在固体支持材料上。 取代的氮杂三环脲荧光染料可用于各种目的，包括用于监测或测定分析物浓度的传感器，如H +（pH），Na +，K +，Ca2 +，O2，CO2，H2O2，离子强度，氧化还原电位 ，金属离子和代谢物。

公开(公告)号：WO2016116111A1

公开(公告)日：2016-07-28

申请号：PCT/DK2016/050016

申请日：2016-01-20

Applicant: KØBENHAVNS UNIVERSITET

Inventor： SØRENSEN, Thomas Just ,  LAURSEN, Bo V. ,  SANTELLA, Marco

IPC: C07D219/04 ,  C07D219/06 ,  C07D219/08 ,  C09D15/00

CPC classification number: C07D219/04 ,  C07D219/06 ,  C07D219/08 ,  C09B11/06 ,  C09B11/24 ,  C09B15/00 ,  C09B57/00 ,  C09D15/00 ,  C09K11/06

Abstract: The present invention relates to a new class of substituted acridinium- and xanthenium-like fluorescent dyes having a 9-x-antracenium rings system. The new substituted fluorescent dyes may be attached to a linker, conjugated to carrier molecule such as e.g. a protein, a nucleic acid, a lipid, or a saccharide, or deposited or immobilised on solid support materials. The substituted fluorescent dyes are useful for various purposes, including use for fluorescence imaging and in sensors for monitoring or determining analytes.

Abstract translation: 本发明涉及一类新的具有9-x-antracenium环系的取代的吖啶鎓和henium状荧光染料。 新的取代的荧光染料可以连接到与载体分子缀合的接头上，例如。 蛋白质，核酸，脂质或糖类，或者沉积或固定在固体支持材料上。 取代的荧光染料可用于各种目的，包括用于荧光成像和用于监测或测定分析物的传感器。