公开(公告)号：WO2020014652A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/041674

申请日：2019-07-12

Applicant: NEW YORK UNIVERSITY

Inventor： KIRSHENBAUM, Kent ,  LOGAN, Susan ,  CRAVEN, Timothy ,  KASPER, Amanda ,  BONNEAU, Richard, A. ,  SCHNEIDER, Jeffrey, A.

IPC: A61K38/12 ,  A61K31/198 ,  A61K38/08

Abstract: Provided are peptoid-peptide macrocycles. The peptoid-peptide macrocycles may have inhibitory activity towards the Wnt signaling pathway. The Wnt signaling pathway is associated with cancer and other diseases and conditions. Such diseases include, for example, pulmonary fibrosis. Also described are methods of making the peptoid-peptide macrocycles, compositions containing the peptoid-peptide macrocycles, and methods of using the peptoid-peptide macrocycles.