公开(公告)号：WO2023086538A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/049655

申请日：2022-11-11

Applicant: INTERDIGITAL VC HOLDINGS, INC. ,  NEW YORK UNIVERSITY

Inventor： WANG, Ruoyu ,  FENG, Chen ,  TIAN, Dong

IPC: G06T7/11 ,  G06T7/187

Abstract: Points are grouped from a point cloud using Concavity-induced Distance (CID). First, a set of seed points is sampled from the input point cloud. Then a grouping of points is conducted based on a nearest neighbor search computed using CID. These two steps enable two novel solutions in point cloud segmentation and scene abstraction. In one embodiment, CID is determined between two points residing within an object surface. In a second embodiment, a CID is determined between groups of points.

公开(公告)号：WO2023014970A2

公开(公告)日：2023-02-09

申请号：PCT/US2022/039572

申请日：2022-08-05

Applicant: NEW YORK UNIVERSITY

Inventor： KOIDE, Shohei ,  WANG, Da-Neng ,  TRAASETH, Nathaniel ,  KOIDE, Akiko ,  BRAWLEY, Douglas ,  SAUER, David

IPC: A61K38/10 ,  A61K47/68 ,  C07K7/08 ,  C07K14/31 ,  C07K14/78 ,  C07K16/12 ,  A61P31/04 ,  A61K38/12

Abstract: Disclosed herein are NorA peptide inhibitors, protein scaffolds including the NorA peptide inhibitor, and antibody-based molecules that bind NorA, as well as compositions containing the same. Also disclosed are combinations therapeutic agents that include an antibiotic and/or biocide; and a NorA inhibitor, protein scaffold, or antibody-based as disclosed herein. Use of these agents for treating a Staphylococcus aureus infection, potentiating the therapeutic efficacy of an antibiotic or biocide, diagnosing a S. aureus infection, and detecting NorA in a non-clinical biological sample are also disclosed.

公开(公告)号：WO2022212667A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022773

申请日：2022-03-31

Applicant: JANSSEN PHARMACEUTICALS, INC. ,  NEW YORK UNIVERSITY

Inventor： MORROW, Brian ,  KONSTANTINOV, Sergey ,  GEURTSEN, Jeroen ,  LUO, Jinquan ,  SOMANI, Sandeep ,  BUCKLEY, Peter, T. ,  TORRES, Victor, J. ,  POOLMAN, Jan, Theunis

IPC: A61P31/04 ,  C07K14/195 ,  A61K39/085

Abstract: The present disclosure relates to immunogenic compositions for inducing an immune response in a subject for the treatment and/or prevention of a Staphylococcus aureus infection. The immunogenic compositions disclosed herein comprise a S. aureus protein A (SpA) polypeptide and a S. aureus Leukocidin A (LukA) and/or Leukocidin B (LukB) variant polypeptide. The present disclosure further relates to methods of generating an immune response against S. aureus in a subject that involve administering the disclosed immunogenic compositions.

公开(公告)号：WO2022187517A1

公开(公告)日：2022-09-09

申请号：PCT/US2022/018744

申请日：2022-03-03

Applicant: NEW YORK UNIVERSITY ,  THE BOARD OF TRUSTESS OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： GUTTENPLAN, Kevin ,  LIDDELOW, Shane

IPC: A61P25/28 ,  A61P35/00 ,  C12N5/0793 ,  C12N5/079

Abstract: The present disclosure relates to methods of inhibiting reactive astrocyte mediated neuronal and/or oligodendrocyte cell death in a subject. In one embodiment, the method involves administering an inhibitor of Elongation of Very Long Chain Fatty Acids Protein 1 (ELOVL1) to a subject having or at risk of having a condition mediated by reactive astrocytes, where the ELOVL1 inhibitor is administered in an amount effective to inhibit reactive astrocyte mediated neuronal and/or oligodendrocyte cell death in the subject. In another embodiment, the method involves administering an inhibitor of lipoapoptosis to a subject having or at risk of having a condition mediated by reactive astrocytes, where the inhibitor of lipoapoptosis is administered in an amount effective to inhibit reactive astrocyte mediate neuronal and/or oligodendrocyte cell death in the subject.

公开(公告)号：WO2022150563A1

公开(公告)日：2022-07-14

申请号：PCT/US2022/011576

申请日：2022-01-07

Applicant: NEW YORK UNIVERSITY

Inventor： AGIN-LIEBES, Gabrielle ,  ROSS, Stephen

IPC: A61K31/4045 ,  A61K31/675 ,  A61P25/24

Abstract: The invention relates to a method of preventing or reducing suicidal ideation and/or desire for hastened death in a patient suffering from a life-threatening disease, the method comprising administering a psychedelic compound which is psilocin or a prodrug of psilocin, or a pharmaceutically acceptable salt thereof, to said patient. Kits useful in the method of the invention are also described.

公开(公告)号：WO2022109299A1

公开(公告)日：2022-05-27

申请号：PCT/US2021/060140

申请日：2021-11-19

Applicant: NEW YORK UNIVERSITY ,  PURETECH LYT, INC

Inventor： FILIPOVIC, Aleksandra ,  KOIDE, Akiko ,  KOIDE, Shohei ,  ELENKO, Eric ,  BOLEN, Joseph

IPC: A61K39/395 ,  C07K16/28 ,  A61P37/06

Abstract: Disclosed herein are methods for treating solid tumors (e.g. , pancreatic adenocarcinoma (PDA), colorectal cancer (CRC), hepatocellular carcinoma (HCC)), or Cholangiocarcinoma and others), including, but not limited to, metastatic tumors, using an anti-Galectin-9 antibody.

公开(公告)号：WO2022103856A1

公开(公告)日：2022-05-19

申请号：PCT/US2021/058807

申请日：2021-11-10

Applicant: NEW YORK UNIVERSITY

Inventor： RAMIREZ, Craig ,  HAUSER, Andrew ,  BEALS, Nathan ,  BAR-SAGI, Dafna ,  KOIDE, Akiko ,  KOIDE, Shohei

IPC: A61K47/64 ,  A61K38/39 ,  C07K14/78 ,  A61P19/08 ,  A61P25/28

Abstract: The present disclosure is directed to pharmaceutical and diagnostic compositions comprising macropinocytosis selective non-binding protein-drug conjugates. These non-binding protein-drug conjugates comprise a non-binding fibronectin type III (FN3) domain coupled to a pharmaceutically active moiety or a diagnostic moiety. The disclosure is also directed to methods of treatment and diagnosis that involve administering the pharmaceutical compositions described herein to a subject in need.

公开(公告)号：WO2022081846A1

公开(公告)日：2022-04-21

申请号：PCT/US2021/054988

申请日：2021-10-14

Applicant: NEW YORK UNIVERSITY

Inventor： BROSH, Ran ,  LAURENT, Jon ,  MAURANO, Matthew ,  BOEKE, Jef, D.

IPC: C12N15/10 ,  C12N15/85 ,  C12N15/90

Abstract: Provided are compositions and methods for using the compositions to modify eukaryotic chromosomes. The methods involve iteratively inserting DNA payloads into a chromosomal locus, or into multiple chromosomal loci. The methods utilize positive and negative selection approaches in combination with one or more recombinases to select cells that contain a payload, eliminate cells that do not contain a payload, and sequentially replace contiguous segments of the chromosome with subsequent payload insertions. Modified cells, and modified mammals containing modified cells, are included.

公开(公告)号：WO2022076795A1

公开(公告)日：2022-04-14

申请号：PCT/US2021/054133

申请日：2021-10-08

Applicant: NEW YORK UNIVERSITY

Inventor： SHETYE, Pradip R. ,  WANGSRIMONGKOL, Buddhathida

IPC: A61B17/24 ,  A61F5/08

Abstract: The present invention provides individual nasal molding devices and methods of making and using the same. This novel technique of pre-surgical nasal molding therapy is ideal for all patients with unilateral and bilateral clefts, including medically compromised patients or patients living far from the cleft centers and periodic office visits are not practical. It is also ideal for patients with incomplete clefts with significant nasal deformity without the involvement of the alveolus or the palate. Postsurgery, the devices can also be used as a nostril retainer to prevent scar contracture and relapse of the primary correction of the nose. The nasal molding devices can be customized for each infant or be provided in standard sizes for ease of utilization and mass production.

公开(公告)号：WO2022072665A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/052923

申请日：2021-09-30

Applicant: NEW YORK UNIVERSITY

Inventor： ROKITO, Andrew, S.

IPC: A61B46/00 ,  A61B46/20 ,  A61B90/00 ,  A61B90/40

Abstract: The present invention provides a method and apparatus for joint distraction during surgical applications. In one embodiment, the present invention provides a method and apparatus for joint distraction during any arthroscopic surgery, comprising: a drape configured for covering at least a portion of a patient during surgery, the drape having a top surface and a bottom surface and is configured to be disposed above the patient when in use during surgery, wherein the drape comprises an opening configured to accept a limb, and an inflatable member, wherein the inflatable member is positioned adjacent to the opening, and is inflated by a fluid from a deflated state to an inflated state.