公开(公告)号：WO2004029073A3

公开(公告)日：2004-08-12

申请号：PCT/US0330285

申请日：2003-09-26

Applicant: TRIMERIS INC

Inventor： BRAY BRIAN ,  KANG MYUNG-CHOL ,  TVERMOES NICOLAI ,  KINDER DANIEL ,  LACKEY JOHN WILLIAM

IPC: C07K7/00 ,  A61K38/00 ,  A61K47/48 ,  C07K14/16 ,  A61K39/21 ,  A61K39/385

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K47/60 ,  C12N2740/16122

Abstract: Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit transmission of HIV to a target cell by adding an amount of effective to inhibit infection of the cell by the virus; and methods of producing the conjugates by operably binding each molecule of synthetic peptide, via a reactive functionality, to the polymer.

Abstract translation: 提供了包含与其可操作结合的聚合物不少于两个分子的衍生自HIV gp41的合成肽的缀合物; 通过加入一定量的有效抑制病毒对细胞的感染来使用这些缀合物来抑制HIV向靶细胞的传播的方法; 以及通过经由反应性官能团将每个合成肽分子可操作地结合到聚合物来产生缀合物的方法。

公开(公告)号：WO2006105199A2

公开(公告)日：2006-10-05

申请号：PCT/US2006011470

申请日：2006-03-28

Applicant: TRIMERIS INC ,  SCHNEIDER STEPHEN ,  MADER CATHERINE J ,  BRAY BRIAN ,  TVERMOES NICOLAI ,  ZHANG HUYI

Inventor： SCHNEIDER STEPHEN ,  MADER CATHERINE J ,  BRAY BRIAN ,  TVERMOES NICOLAI ,  ZHANG HUYI

IPC: C07K1/02

CPC classification number: C07K14/005 ,  A61K47/542 ,  C12N2740/16122

Abstract: Provided are peptide fragments which may be used in a method of producing a synthetic peptide, or a conjugate comprised of the synthetic peptide operatively linked to fatty acid, wherein the method comprises chemically coupling 2 or more peptide fragments together in a process of assembly to produce the synthetic peptide or conjugate.

Abstract translation: 提供了可用于制备合成肽的方法的肽片段或由可操作地连接到脂肪酸的合成肽组成的缀合物，其中所述方法包括在组装过程中将2个或更多个肽片段化学偶联在一起，以产生 合成肽或缀合物。