公开(公告)号：WO2009042194A3

公开(公告)日：2009-05-14

申请号：PCT/US2008011147

申请日：2008-09-25

Applicant: TRIMERIS INC ,  BRAY BRIAN L ,  JOHNSTON BARBARA E ,  SCHNEIDER STEPHEN E ,  TVERMOES NICOLAI A ,  ZHANG HUYI ,  FRIEDRICH PAUL E

Inventor： BRAY BRIAN L ,  JOHNSTON BARBARA E ,  SCHNEIDER STEPHEN E ,  TVERMOES NICOLAI A ,  ZHANG HUYI ,  FRIEDRICH PAUL E

IPC: C07K14/16

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122

Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

Abstract translation: 本文提供了合成肽的方法。 特别地，本文提供了治疗性抗病毒肽的合成方法。

公开(公告)号：WO2006069779A1

公开(公告)日：2006-07-06

申请号：PCT/EP2005/014051

申请日：2005-12-27

Applicant: F. HOFFMANN-LA ROCHE AG ,  DAUER, Richard, R. ,  EVANSON, Christina, M. ,  FRIEDRICH, Paul, Erickson ,  HAFEZZADEH, Hafez ,  NALITHAM, Ramakrishna, V. ,  SCHNEIDER, Stephen, Edward ,  SCHWINDT, Mark, A. ,  SNYDER, Roger, C. ,  WHITE, Joseph, L. ,  WITHERS, Gregory, P.

Inventor： DAUER, Richard, R. ,  EVANSON, Christina, M. ,  FRIEDRICH, Paul, Erickson ,  HAFEZZADEH, Hafez ,  NALITHAM, Ramakrishna, V. ,  SCHNEIDER, Stephen, Edward ,  SCHWINDT, Mark, A. ,  SNYDER, Roger, C. ,  WHITE, Joseph, L. ,  WITHERS, Gregory, P.

IPC: C07K14/605 ,  C07K14/16 ,  C07K1/30

CPC classification number: C07K14/005 ,  C07K1/145 ,  C07K1/303 ,  C07K14/605 ,  C12N2740/16122

Abstract: The formation of inactive, insoluble forms of peptide can be minimized or, alternatively, inactive, insoluble forms of peptide compounds, if present, can be converted into more physiologically active, soluble forms by dissolving peptide samples in aqueous base and then acidifying the aqueous mixture to precipitate the peptide in the presence of at least one of a salt and a co-solvent. Preferably, both a salt and co-solvent are present. By carrying out the precipitation relatively rapidly (at least in a first stage of acidifying in which the pH of the alkaline medium is reduced to a pH in the range of 6 to 7.5, after which acidification to a final desired pH, e.g., 3 to 6, can occur more slowly) at relatively low temperature, the dissolution characteristics of the resultant precipitated peptide are even further improved. The process is robust, consistent, and suitable for commercial scale manufacture of peptides.

Abstract translation: 通过将肽样品溶解在碱性水溶液中，然后将含水混合物酸化，可以将肽的无活性，不溶性形式的形成最小化，或者可选地，非活性的肽化合物的不溶形式（如果存在）可以转化为更具生理活性的可溶形式 以在盐和共溶剂中的至少一种的存在下沉淀肽。 优选地，存在盐和共溶剂。 通过相对快速地进行沉淀（至少在第一阶段的酸化中，将碱性介质的pH降低至6至7.5范围内的pH，然后酸化至最终所需的pH，例如3至 6，可以更慢地发生），在所得沉淀肽的溶解特性进一步提高。 该方法稳健，一致，适用于商业规模生产肽。

公开(公告)号：WO2011156355A1

公开(公告)日：2011-12-15

申请号：PCT/US2011/039420

申请日：2011-06-07

Applicant: KAINOS MEDICINE, INC. ,  JOHNSON, Michael, Ross ,  KANG, Myung-chol ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen

Inventor： JOHNSON, Michael, Ross ,  KANG, Myung-chol ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen

IPC: A61K31/4965 ,  A61K31/155

CPC classification number: C07D241/26 ,  C07C271/16

Abstract: This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.

Abstract translation: 本发明涉及具有药理学活性的苯基胍盐的制备方法，以及用作生产具有药理活性的苯基胍盐的中间体的化合物的鉴定和合成。

公开(公告)号：WO2006105199A2

公开(公告)日：2006-10-05

申请号：PCT/US2006011470

申请日：2006-03-28

Applicant: TRIMERIS INC ,  SCHNEIDER STEPHEN ,  MADER CATHERINE J ,  BRAY BRIAN ,  TVERMOES NICOLAI ,  ZHANG HUYI

Inventor： SCHNEIDER STEPHEN ,  MADER CATHERINE J ,  BRAY BRIAN ,  TVERMOES NICOLAI ,  ZHANG HUYI

IPC: C07K1/02

CPC classification number: C07K14/005 ,  A61K47/542 ,  C12N2740/16122

Abstract: Provided are peptide fragments which may be used in a method of producing a synthetic peptide, or a conjugate comprised of the synthetic peptide operatively linked to fatty acid, wherein the method comprises chemically coupling 2 or more peptide fragments together in a process of assembly to produce the synthetic peptide or conjugate.

Abstract translation: 提供了可用于制备合成肽的方法的肽片段或由可操作地连接到脂肪酸的合成肽组成的缀合物，其中所述方法包括在组装过程中将2个或更多个肽片段化学偶联在一起，以产生 合成肽或缀合物。

公开(公告)号：WO1987004399A1

公开(公告)日：1987-07-30

申请号：PCT/US1987000237

申请日：1987-01-21

Applicant: KRANSCO MANUFACTURING, INC. ,  GELLER, Douglas, A. ,  SCHNEIDER, Stephen, E.

Inventor： KRANSCO MANUFACTURING, INC.

IPC: B63B41/00

CPC classification number: B63B35/7926

Abstract: A generally trapezoidal fin (22) is pivotally fastened to a casing which can receive the entire fin, permitting total retraction of the fin. The casing is formed with at least one notch (42) for selectively positioning the fin relative to the casing. In a preferred embodiment, the fin is operated by a lever member (26) which has a knob (50) at its distal end for use in positioning the fin (22) from above.

Abstract translation: 大致梯形的翅片（22）枢转地固定到可以容纳整个翅片的壳体上，允许翅片完全缩回。 壳体形成有至少一个凹口（42），用于相对于壳体选择性地定位翅片。 在优选实施例中，翅片由杠杆构件（26）操作，杠杆构件（26）在其远端具有旋钮（50），用于从上方定位翅片（22）。

公开(公告)号：WO2009042194A2

公开(公告)日：2009-04-02

申请号：PCT/US2008/011147

申请日：2008-09-25

Applicant: TRIMERIS, INC. ,  BRAY, Brian, L. ,  JOHNSTON, Barbara, E. ,  SCHNEIDER, Stephen, E. ,  TVERMOES, Nicolai, A. ,  ZHANG, Huyi ,  FRIEDRICH, Paul, E.

Inventor： BRAY, Brian, L. ,  JOHNSTON, Barbara, E. ,  SCHNEIDER, Stephen, E. ,  TVERMOES, Nicolai, A. ,  ZHANG, Huyi ,  FRIEDRICH, Paul, E.

IPC: C07K14/16

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122

Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

Abstract translation: 本文提供了合成肽的方法。 特别地，本文提供了治疗性抗病毒肽的合成方法。

公开(公告)号：WO2007097903A3

公开(公告)日：2007-08-30

申请号：PCT/US2007/002990

申请日：2007-02-02

Applicant: TRIMERIS, INC. ,  DWYER, John ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen, E. ,  ZHANG, Huyi ,  TVERMOES, Nicolai, A. ,  JOHNSTON, Barbara, E. ,  FRIEDRICH, Paul, E.

Inventor： DWYER, John ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen, E. ,  ZHANG, Huyi ,  TVERMOES, Nicolai, A. ,  JOHNSTON, Barbara, E. ,  FRIEDRICH, Paul, E.

IPC: C07K5/00

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9. SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO: 15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

公开(公告)号：WO2007097903A2

公开(公告)日：2007-08-30

申请号：PCT/US2007002990

申请日：2007-02-02

Applicant: TRIMERIS INC ,  DWYER JOHN ,  BRAY BRIAN L ,  SCHNEIDER STEPHEN E ,  ZHANG HUYI ,  TVERMOES NICOLAI A ,  JOHNSTON BARBARA E ,  FRIEDRICH PAUL E

Inventor： DWYER JOHN ,  BRAY BRIAN L ,  SCHNEIDER STEPHEN E ,  ZHANG HUYI ,  TVERMOES NICOLAI A ,  JOHNSTON BARBARA E ,  FRIEDRICH PAUL E

IPC: C07K14/00 ,  A61K38/00 ,  C07K1/00 ,  C07K2/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2740/16022 ,  C12N2740/16122 ,  G01N2333/16 ,  G01N2800/26

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9. SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO: 15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

Abstract translation: 本发明提供具有SEQ ID NO：9中任一项的氨基酸序列的HIV融合抑制肽。 SEQ ID NO：10，SEQ ID NO：11，SEQ ID NO：12，SEQ ID NO：13，SEQ ID NO：14或SEQ ID NO：15; 并且提供了包含HIV融合抑制剂肽和药学上可接受的载体和大分子载体中的一种或多种的药物组合物，以及由这些组合物提供的用途和治疗方法。

公开(公告)号：WO2006105201A3

公开(公告)日：2006-10-05

申请号：PCT/US2006/011474

申请日：2006-03-28

Applicant: TRIMERIS, INC. ,  WRING, Stephen ,  FRICK, Lloyd ,  SCHNEIDER, Stephen ,  ZHANG, Huyi ,  DI, Jie ,  HEILMAN, David

Inventor： WRING, Stephen ,  FRICK, Lloyd ,  SCHNEIDER, Stephen ,  ZHANG, Huyi ,  DI, Jie ,  HEILMAN, David

IPC: C07K5/00

Abstract: Provided is a conjugate comprised of HIV gp41 -derived peptide operatively linked to fatty acid, and pharmaceutical compositions and medicaments containing the conjugate. Also provided are methods for producing a conjugate according to the present invention which include, but are not limited to, covalently coupling a linker to the HIV gp41 -derived peptide, wherein the linker is covalently coupled to fatty acid.

公开(公告)号：WO2006105199A3

公开(公告)日：2006-10-05

申请号：PCT/US2006/011470

申请日：2006-03-28

Applicant: TRIMERIS, INC. ,  SCHNEIDER, Stephen ,  MADER, Catherine, J. ,  BRAY, Brian ,  TVERMOES, Nicolai ,  ZHANG, Huyi

Inventor： SCHNEIDER, Stephen ,  MADER, Catherine, J. ,  BRAY, Brian ,  TVERMOES, Nicolai ,  ZHANG, Huyi

IPC: A61K38/00

Abstract: Provided are peptide fragments which may be used in a method of producing a synthetic peptide, or a conjugate comprised of the synthetic peptide operatively linked to fatty acid, wherein the method comprises chemically coupling 2 or more peptide fragments together in a process of assembly to produce the synthetic peptide or conjugate.