公开(公告)号：WO2011156355A1

公开(公告)日：2011-12-15

申请号：PCT/US2011/039420

申请日：2011-06-07

Applicant: KAINOS MEDICINE, INC. ,  JOHNSON, Michael, Ross ,  KANG, Myung-chol ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen

Inventor： JOHNSON, Michael, Ross ,  KANG, Myung-chol ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen

IPC: A61K31/4965 ,  A61K31/155

CPC classification number: C07D241/26 ,  C07C271/16

Abstract: This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.

Abstract translation: 本发明涉及具有药理学活性的苯基胍盐的制备方法，以及用作生产具有药理活性的苯基胍盐的中间体的化合物的鉴定和合成。

公开(公告)号：WO2011063156A3

公开(公告)日：2011-05-26

申请号：PCT/US2010/057289

申请日：2010-11-18

Applicant: NEKTAR THERAPEUTICS ,  CHONG, Anthony, O. ,  LEE, Seoju ,  JOSHI, Bhalchandra, V. ,  BRAY, Brian ,  NIE, Shaoyong ,  SPENCE, Patrick ,  KOZLOWSKI, Antoni ,  MCMANUS, Samuel ,  TIPNIS, Sachin ,  LAVATY, Greg ,  SWALLOW, David

Inventor： CHONG, Anthony, O. ,  LEE, Seoju ,  JOSHI, Bhalchandra, V. ,  BRAY, Brian ,  NIE, Shaoyong ,  SPENCE, Patrick ,  KOZLOWSKI, Antoni ,  MCMANUS, Samuel ,  TIPNIS, Sachin ,  LAVATY, Greg ,  SWALLOW, David

IPC: A61K47/48 ,  A61P35/00 ,  C08G65/08 ,  C08G65/14 ,  C08G65/26

Abstract: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-sail acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.

公开(公告)号：WO2007012059A3

公开(公告)日：2007-01-25

申请号：PCT/US2006/028271

申请日：2006-07-19

Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  KOZLOWSKI, Antoni ,  HANDLEY, John ,  SCHAEFER, Anthony, G. ,  BRAY, Brian ,  ODOM, Ryan ,  SANDER, Tony, L.

Inventor： KOZLOWSKI, Antoni ,  HANDLEY, John ,  SCHAEFER, Anthony, G. ,  BRAY, Brian ,  ODOM, Ryan ,  SANDER, Tony, L.

IPC: C08G65/329 ,  A61K47/48

Abstract: Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the polymeric reagents, and conjugates prepared by polymeric reagents obtained by the described methods.

公开(公告)号：WO2006105199A2

公开(公告)日：2006-10-05

申请号：PCT/US2006011470

申请日：2006-03-28

Applicant: TRIMERIS INC ,  SCHNEIDER STEPHEN ,  MADER CATHERINE J ,  BRAY BRIAN ,  TVERMOES NICOLAI ,  ZHANG HUYI

Inventor： SCHNEIDER STEPHEN ,  MADER CATHERINE J ,  BRAY BRIAN ,  TVERMOES NICOLAI ,  ZHANG HUYI

IPC: C07K1/02

CPC classification number: C07K14/005 ,  A61K47/542 ,  C12N2740/16122

Abstract: Provided are peptide fragments which may be used in a method of producing a synthetic peptide, or a conjugate comprised of the synthetic peptide operatively linked to fatty acid, wherein the method comprises chemically coupling 2 or more peptide fragments together in a process of assembly to produce the synthetic peptide or conjugate.

Abstract translation: 提供了可用于制备合成肽的方法的肽片段或由可操作地连接到脂肪酸的合成肽组成的缀合物，其中所述方法包括在组装过程中将2个或更多个肽片段化学偶联在一起，以产生 合成肽或缀合物。

公开(公告)号：WO2005056636A2

公开(公告)日：2005-06-23

申请号：PCT/US2004040712

申请日：2004-12-03

Applicant: NEKTAR THERAPEUTICS AL CORP ,  MCMANUS SAMUEL P ,  KOZLOWSKI ANTONI ,  HUTCHISON TRACY L ,  BRAY BRIAN ,  SHEN XIAOMING

Inventor： MCMANUS SAMUEL P ,  KOZLOWSKI ANTONI ,  HUTCHISON TRACY L ,  BRAY BRIAN ,  SHEN XIAOMING

IPC: A61K47/48 ,  C08G65/333 ,  C08G69/08 ,  C08G65/00

CPC classification number: C07D403/12 ,  A61K47/60 ,  C08G65/33337 ,  C08G69/08

Abstract: Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

Abstract translation: 提供了形成马来酰亚胺官能化聚合物的方法。 在一个这样的实施方案中，马来酰亚胺官能化聚合物在包括进行反向Diels-Alder反应的步骤的方法中制备。 还提供了可用于该方法的中间体以及制备中间体的方法。 还提供了聚合物试剂，使用聚合物试剂，化合物和共轭物的方法。

公开(公告)号：WO2010047826A3

公开(公告)日：2011-06-09

申请号：PCT/US2009005781

申请日：2009-10-23

Applicant: TRIMERIS INC ,  BRAY BRIAN L ,  DI JIE ,  GREENBERG MICHAEL ,  HEILMAN DAVID ,  OHMSTEDE CAROL ,  SILINSKI PETER ,  WEBB SCOTT

Inventor： BRAY BRIAN L ,  DI JIE ,  GREENBERG MICHAEL ,  HEILMAN DAVID ,  OHMSTEDE CAROL ,  SILINSKI PETER ,  WEBB SCOTT

IPC: A61K9/00

CPC classification number: A61K38/162

Abstract: Provided herein are dosage formulations and dosing regimens of an antiviral peptide therapeutic, including methods of using the same.

Abstract translation: 本文提供了抗病毒肽治疗剂的剂型和给药方案，包括使用它们的方法。

公开(公告)号：WO2006105199A3

公开(公告)日：2006-10-05

申请号：PCT/US2006/011470

申请日：2006-03-28

Applicant: TRIMERIS, INC. ,  SCHNEIDER, Stephen ,  MADER, Catherine, J. ,  BRAY, Brian ,  TVERMOES, Nicolai ,  ZHANG, Huyi

Inventor： SCHNEIDER, Stephen ,  MADER, Catherine, J. ,  BRAY, Brian ,  TVERMOES, Nicolai ,  ZHANG, Huyi

IPC: A61K38/00

Abstract: Provided are peptide fragments which may be used in a method of producing a synthetic peptide, or a conjugate comprised of the synthetic peptide operatively linked to fatty acid, wherein the method comprises chemically coupling 2 or more peptide fragments together in a process of assembly to produce the synthetic peptide or conjugate.

公开(公告)号：WO2010047826A2

公开(公告)日：2010-04-29

申请号：PCT/US2009/005781

申请日：2009-10-23

Applicant: TRIMERIS, INC. ,  BRAY, Brian, L. ,  DI, Jie ,  GREENBERG, Michael ,  HEILMAN, David ,  OHMSTEDE, Carol ,  SILINSKI, Peter ,  WEBB, Scott

Inventor： BRAY, Brian, L. ,  DI, Jie ,  GREENBERG, Michael ,  HEILMAN, David ,  OHMSTEDE, Carol ,  SILINSKI, Peter ,  WEBB, Scott

IPC: A61K9/00

CPC classification number: A61K38/162

Abstract: Provided herein are dosage formulations and dosing regimens of an antiviral peptide therapeutic, including methods of using the same.

Abstract translation: 本文提供了抗病毒肽治疗剂的剂型和给药方案，包括使用它们的方法。

公开(公告)号：WO2009042194A3

公开(公告)日：2009-05-14

申请号：PCT/US2008011147

申请日：2008-09-25

Applicant: TRIMERIS INC ,  BRAY BRIAN L ,  JOHNSTON BARBARA E ,  SCHNEIDER STEPHEN E ,  TVERMOES NICOLAI A ,  ZHANG HUYI ,  FRIEDRICH PAUL E

Inventor： BRAY BRIAN L ,  JOHNSTON BARBARA E ,  SCHNEIDER STEPHEN E ,  TVERMOES NICOLAI A ,  ZHANG HUYI ,  FRIEDRICH PAUL E

IPC: C07K14/16

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122

Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

Abstract translation: 本文提供了合成肽的方法。 特别地，本文提供了治疗性抗病毒肽的合成方法。

公开(公告)号：WO2008124013A1

公开(公告)日：2008-10-16

申请号：PCT/US2008/004307

申请日：2008-04-02

Applicant: TRIMERIS, INC. ,  BRAY, Brian, L. ,  DI, Jie ,  HEILMAN, David ,  SILINSKI, Peter ,  WEBB, Scott

Inventor： BRAY, Brian, L. ,  DI, Jie ,  HEILMAN, David ,  SILINSKI, Peter ,  WEBB, Scott

IPC: A61K47/48

CPC classification number: A61K38/162 ,  A61K9/0024 ,  A61K38/19 ,  A61K47/26 ,  A61K47/34 ,  A61K2300/00

Abstract: Provided herein are compositions and methods for their administration as therapeutic agents. In particular, provided herein are compositions and their use for the administration of antiviral peptide therapeutics.

Abstract translation: 本文提供了作为治疗剂施用的组合物和方法。 特别地，本文提供了组合物及其用于施用抗病毒肽治疗剂的用途。