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    A METHOD OF DETECTING HFMD
    91.
    发明申请
    A METHOD OF DETECTING HFMD 审中-公开

    公开(公告)号：WO2020022959A1

    公开(公告)日：2020-01-30

    申请号：PCT/SG2019/050354

    申请日：2019-07-23

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： CHU, Justin Jang Hann ,  TEO, Fiona Mei Shan

    IPC: G01N33/563

    Abstract: The present invention relates to a method of detecting Hand-Foot-and-Mouth Disease (HFMD) in samples obtained from test subjects. In particular, the method relates to the detection of protein biomarkers in the saliva of these test subjects. In a preferred embodiment, the method comprising detecting in a saliva sample the presence and/or amount of at least one protein biomarker selected from the group consisting of PRX-IV, Legumain, SIL1 and CREG1, wherein the presence of the protein biomarker in the saliva is indicative of HFMD.

    METHOD FOR SCREENING SPLICING VARIANTS OR EVENTS
    92.
    发明申请
    METHOD FOR SCREENING SPLICING VARIANTS OR EVENTS 审中-公开

    公开(公告)号：WO2019032054A1

    公开(公告)日：2019-02-14

    申请号：PCT/SG2018/050408

    申请日：2018-08-13

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： WEE, Keng Boon

    IPC: C12Q1/6813 ,  C12N15/113

    Abstract: The present invention relates to a high-throughput method of screening splicing variants of target genes as drug targets or for characterisation of their biological functions. The disclosure provides a method for the screening of splicing variants, comprising: (a) providing a first antisense oligonucleotide capable of inducing a first splice event on the target gene to express a first splicing variant, and a second antisense oligonucleotide capable of inducing a second splice event on the target gene to express a second splicing variant; (b) hybridising the first and second antisense oligonucleotides to a pre-mRNA of the target gene; and (c) characterising the effect of the splice event. In one embodiment, the first antisense oligonucleotide switches the splice event that expresses the second splicing variant towards one that expresses the first splicing variant, while the second antisense oligonucleotide switches the splice event that expresses the first splicing variant towards one that expresses the second splicing variant.

    A DETECTION METHOD
    97.
    发明申请
    A DETECTION METHOD 审中-公开

    公开(公告)号：WO2018174830A1

    公开(公告)日：2018-09-27

    申请号：PCT/SG2018/050134

    申请日：2018-03-26

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

    Inventor： CHU, Jang Hann, Justin ,  NYO, Min

    IPC: C12Q1/6851 ,  A61K31/7088 ,  A61P31/14

    Abstract: The present invention relates to a method of detecting Hand-Foot-and-Mouth Disease (HMFD) in subjects. In particular, the method relates to detecting promising biomarkers in the saliva of these subjects. In an aspect of the present invention, there is provided a method for detecting HFMD, the method comprising determining the presence of a microRNA (miRNA) in a saliva sample, wherein the presence of the miRNA in the saliva sample is indicative of HFMD. Preferably, the miRNA is any one selected from the group consisting of mir-18b, mir-125a, mir-145, mir-155, mir-221, mir-324, mir- 335 and further comprises mir-23a and mir-142.

    A MOVABLE WORK SURFACE APPARATUS
    98.
    发明申请
    A MOVABLE WORK SURFACE APPARATUS 审中-公开
    可移动的工作表面装置

    公开(公告)号：WO2017200488A1

    公开(公告)日：2017-11-23

    申请号：PCT/SG2017/050258

    申请日：2017-05-18

    Applicant: IDEAL WORKSPACE PTE LTD

    Inventor： DENG, Yuying ,  MCDONNELL, Andrew ,  BUTALIA, Siddartha ,  YANG, Thomas Zhong Ming

    IPC: A47B21/02 ,  A47B17/02 ,  A47B9/00 ,  A47B97/00

    Abstract: A workstation apparatus for use on a flat surface, the workstation apparatus comprising: a base configured to be disposed on a support surface which is elevated from a floor surface; a fixed pillar attached to the base; a movable pillar movably attached to the fixed pillar; a work surface attached to the movable pillar; and a displacement mechanism configured to move the movable pillar between a lowered position and a raised position, a switch to control the displacement mechanism; at least one proximity sensor configured to detect an object and measure an object distance; and a control unit communicably coupled to the proximity sensor, configured to: determine a presence or absence of a user if a presence of the object and object motion are determined; and record a time stamp information and a position of the work surface; the workstation apparatus allowing a user to convert any elevated support surface like a desk to a sit-stand desk.

    Abstract translation: 1。一种用于平坦表面的工作站装置，所述工作站装置包括：基座，所述基座被构造成布置在从地板表面升高的支撑表面上; 固定在基座上的支柱; 可移动的柱，其可移动地附接到所述固定柱; 附接到可移动柱的工作表面; 以及位移机构，该位移机构构造成使所述可移动柱在降低位置和升高位置之间移动，开关，用于控制所述位移机构; 至少一个接近传感器，被配置为检测物体并测量物体距离; 以及可通信地耦合到所述接近传感器的控制单元，所述控制单元被配置为：如果确定了所述对象和对象运动的存在，则确定用户的存在或不存在; 并记录时间戳信息和工作表面的位置; 工作站设备允许用户将任何高架支撑表面（如桌子）转换为坐立桌。

    JAK AND HDAC DUAL-INHIBITOR COMPOUNDS
    99.
    发明申请
    JAK AND HDAC DUAL-INHIBITOR COMPOUNDS 审中-公开
    JAK和HDAC双抑制剂化合物

    公开(公告)号：WO2017196261A1

    公开(公告)日：2017-11-16

    申请号：PCT/SG2017/050248

    申请日：2017-05-11

    Applicant: NATIONAL UNIVERSITY OF SINGAPORE ,  ACADEMIA SINICA

    Inventor： DYMOCK, Brian William ,  YANG, Eugene Guorong ,  YEN, Jong-Young ,  TAN, Eng Chong

    IPC: C07D498/12 ,  A61K31/505 ,  A61P35/00 ,  A61P37/06

    Abstract: The present disclosure described provides novel dual inhibition compounds that specifically target the JAK-STAT and HDAC pathways, two distinct cellular pathways that are useful in the treatment of various diseases and disorders. In certain aspects, the compounds described herein are useful in the treatment of cellular proliferative and inflammatory diseases or disorders, such as graft vs. host disease. In particular embodiments, the compounds described herein inhibit JAK2 and HDAC6.

    Abstract translation: 所描述的本公开提供了特异性靶向JAK-STAT和HDAC途径的新型双重抑制化合物，两种不同的细胞途径可用于治疗各种疾病和病症。 在某些方面，本文所述的化合物可用于治疗细胞增殖性和炎性疾病或病症，例如移植物抗宿主病。 在具体的实施方案中，本文所述的化合物抑制JAK2和HDAC6。

    TRANS-SPLICING RNA (TSRNA)
    100.
    发明申请
    TRANS-SPLICING RNA (TSRNA) 审中-公开
    反式拼接RNA（TSRNA）

    公开(公告)号：WO2017171654A1

    公开(公告)日：2017-10-05

    申请号：PCT/SG2017/050183

    申请日：2017-03-31

    Applicant: NATIONAL UNIVERSITY OF SINGAPORE

    Inventor： PATZEL, Volker ,  PODDAR, Sushmita

    IPC: C12N15/85 ,  C12N15/38 ,  C12N15/64 ,  C12N15/11 ,  A61K48/00

    Abstract: The invention concerns a trans-splicing RNA (tsRNA) molecule comprising one or multiple unstructured binding domains; a cell or vector comprising said tsRNA; and a method for killing cells or treating a disease using said tsRNA.

    Abstract translation: 本发明涉及包含一个或多个非结构化结合结构域的反式剪接RNA（tsRNA）分子; 包含所述tsRNA的细胞或载体; 以及使用所述tsRNA杀死细胞或治疗疾病的方法。

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