公开(公告)号：WO2018194520A9

公开(公告)日：2018-10-25

申请号：PCT/SG2018/050194

申请日：2018-04-18

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： LOBIE, Peter Edward ,  PANDEY, Vijay Kumar ,  KANCHUGARAKOPPAL SUBBEGOWDA, Rangappa ,  SALUNDI, Bassappa ,  CHAKRABHAVI DHANANJAYA, Mohan ,  RANGAPPA, Shobith ,  VENKATACHALAIAH, Srinivasa

IPC分类号： C07D211/06 ,  C07D241/04 ,  A61K31/445 ,  A61K31/496 ,  A61P35/00

摘要： The invention relates to compounds of general formula (I): wherein R 1 , n, R 2a , R 2b , and R 3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.

公开(公告)号：WO2018194520A1

公开(公告)日：2018-10-25

申请号：PCT/SG2018/050194

申请日：2018-04-18

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： LOBIE, Peter Edward ,  PANDEY, Vijay Kumar ,  KANCHUGARAKOPPAL SUBBEGOWDA, Rangappa ,  SALUNDI, Bassappa ,  CHAKRABHAVI DHANANJAYA, Mohan ,  RANGAPPA, Shobith ,  VENKATACHALAIAH, Srinivasa

IPC分类号： C07D211/06 ,  C07D241/04 ,  A61K31/445 ,  A61K31/496 ,  A61P35/00

摘要： The invention relates to compounds of general formula (I): wherein R 1 , n, R 2a , R 2b , and R 3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.

公开(公告)号：WO2018226155A1

公开(公告)日：2018-12-13

申请号：PCT/SG2018/050277

申请日：2018-06-05

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： LOBIE, Peter Edward ,  PANDEY, Vijay Kumar ,  KANCHUGARAKOPPAL SUBBEGOWDA, Rangappa ,  BASAPPA, Basappa ,  CHAKRABHAVI DHANANJAYA, Mohan ,  RANGAPPA, Shobith

IPC分类号： C07D493/04 ,  C07D491/22 ,  A61K31/519 ,  A61K31/37 ,  A61P35/00

摘要： The present invention relates to compounds of Formula I, wherein A, R 1 to R 6 , and x to z are defined herein, and their use in inhibiting Human trefoil factor 3.