公开(公告)号：WO2022161423A1

公开(公告)日：2022-08-04

申请号：PCT/CN2022/074190

申请日：2022-01-27

申请人： 深圳晶泰科技有限公司

发明人： 程辉敏 ,  温晓明 ,  张佩宇 ,  刘志强 ,  罗岚 ,  赖力鹏 ,  马健 ,  温书豪

IPC分类号： C07D211/06 ,  A61K31/453 ,  A61K31/40 ,  A61P29/00

摘要： 提供了一种式I化合物及其制备方法和应用，包括所述化合物作为活性成分的药物组合物或其药学上可接受的盐。还提供了式I化合物在治疗和预防EP 4受体相关疾病的用途。

公开(公告)号：WO2022067165A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/052163

申请日：2021-09-27

申请人： YALE UNIVERSITY ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

发明人： ELLMAN, Jonathan ,  CONFAIR, Danielle ,  KWEON, Oh Sang ,  ROTH, Bryan ,  KIM, Kuglae ,  SHOICHET, Brian ,  LEVIT, Anat ,  IRIWIN, John J.

IPC分类号： A61K31/41 ,  A61K31/415 ,  A61K31/4462 ,  C07D211/06 ,  C07D211/08 ,  C07D231/10

摘要： The present disclosure describes in one aspect tetrahydropyridine compounds of formula (I), which are 5-HT2A receptor agonists that exhibit selective binding to the 5-HT2A receptor over the 5-HT2B receptor. In certain embodiments, the compound of formula (I) is a compound of formula (II). Also provided herein are methods of treating, ameliorating, and/or preventing neurological diseases and disorders with compounds of formula (II).

公开(公告)号：WO2022056045A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/049534

申请日：2021-09-08

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  LYNCH, Kevin R. ,  KHAREL, Yugesh ,  SANTOS, Webster L. ,  FRITZEMEIER, Russell G. ,  BURGIO, Ariel Louise ,  SHRADER, Christopher ,  FOSTER, Daniel

发明人： LYNCH, Kevin R. ,  KHAREL, Yugesh ,  SANTOS, Webster L. ,  FRITZEMEIER, Russell G. ,  BURGIO, Ariel Louise ,  SHRADER, Christopher ,  FOSTER, Daniel

IPC分类号： C07D205/04 ,  C07D207/06 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/06 ,  C07D211/34 ,  C07D211/56 ,  C07D241/04 ,  A61K31/4406 ,  A61K31/401 ,  A61P35/00 ,  A61P37/00

摘要： The present disclosure provides SPNS2 inhibitor compounds according to Formula (IA) and Formula (I), and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.

公开(公告)号：WO2020142657A1

公开(公告)日：2020-07-09

申请号：PCT/US2020/012136

申请日：2020-01-03

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  CHILDREN'S MEDICAL CENTER CORPORATION

发明人： BEAN, Bruce, P. ,  WOOLF, Clifford, J. ,  LEE, Jinbo ,  JO, Sooyeon ,  TOCHITSKY, Ivan

IPC分类号： A61K31/14 ,  C07D211/06

摘要： The invention provides compounds, compositions, methods and kits for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：WO2019003142A1

公开(公告)日：2019-01-03

申请号：PCT/IB2018/054761

申请日：2018-06-27

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： EVINDAR, Ghotas ,  KAZMIERSKI, Wieslaw Mieczyslaw ,  MILLER, John Franklin ,  SAMANO, Vicente ,  SUWANDI, Lita ,  TEMELKOFF, David ,  WASHIO, Yoshiaki ,  XIA, Bing

IPC分类号： C07D401/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D211/06 ,  A61P35/00 ,  A61K31/4545

摘要： Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases. Formula I

公开(公告)号：WO2018194520A9

公开(公告)日：2018-10-25

申请号：PCT/SG2018/050194

申请日：2018-04-18

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： LOBIE, Peter Edward ,  PANDEY, Vijay Kumar ,  KANCHUGARAKOPPAL SUBBEGOWDA, Rangappa ,  SALUNDI, Bassappa ,  CHAKRABHAVI DHANANJAYA, Mohan ,  RANGAPPA, Shobith ,  VENKATACHALAIAH, Srinivasa

IPC分类号： C07D211/06 ,  C07D241/04 ,  A61K31/445 ,  A61K31/496 ,  A61P35/00

摘要： The invention relates to compounds of general formula (I): wherein R 1 , n, R 2a , R 2b , and R 3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.

公开(公告)号：WO2018194520A1

公开(公告)日：2018-10-25

申请号：PCT/SG2018/050194

申请日：2018-04-18

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  UNIVERSITY OF MYSORE ,  BANGALORE UNIVERSITY

发明人： LOBIE, Peter Edward ,  PANDEY, Vijay Kumar ,  KANCHUGARAKOPPAL SUBBEGOWDA, Rangappa ,  SALUNDI, Bassappa ,  CHAKRABHAVI DHANANJAYA, Mohan ,  RANGAPPA, Shobith ,  VENKATACHALAIAH, Srinivasa

IPC分类号： C07D211/06 ,  C07D241/04 ,  A61K31/445 ,  A61K31/496 ,  A61P35/00

摘要： The invention relates to compounds of general formula (I): wherein R 1 , n, R 2a , R 2b , and R 3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.

公开(公告)号：WO2017176461A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/023762

申请日：2017-03-23

申请人： RESEARCH TRIANGLE INSTITUTE

发明人： RUNYON, Scott ,  HASSLER, Carla ,  SHINER, Craig ,  NARAYANAN, Sanju

IPC分类号： C07C235/40 ,  C07D211/06 ,  A61K31/198 ,  A61K31/445

摘要： Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.

摘要翻译： 提供了神经肽S受体激动剂。 NPS激动剂包括对神经肽S受体表现出亲和力和活性的拟肽类似物。 所述分子可用于治疗由神经肽S受体调节介导的病症，综合征和病症，例如物质滥用，发作性睡病，失眠，肥胖症，认知衰退，痴呆，阿尔茨海默氏病，恐慌症，广泛性焦虑症，PTSD，恐怖症 ，精神分裂症和在认知行为治疗中的任何一种戒烟计划中的支持性药物，如药物成瘾，饮食失调和赌博。

公开(公告)号：WO2014127256A1

公开(公告)日：2014-08-21

申请号：PCT/US2014/016519

申请日：2014-02-14

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  THE UNIVERSITY OF KANSAS ,  JAVITCH, Jonathan ,  RIVES, Marie-Laure ,  FILIZOLA, Marta ,  PRISINZANO, Thomas E.

发明人： JAVITCH, Jonathan ,  RIVES, Marie-Laure ,  FILIZOLA, Marta ,  PRISINZANO, Thomas E.

IPC分类号： A61K31/445 ,  C07D211/06

CPC分类号： C07D417/12

摘要： The present invention provides, inter alia, compounds of formula (I): (structurally represented). Also provided are pharmaceutical compositions containing such compounds and methods for treating or ameliorating the effects of a medical condition in a subject using such compounds or pharmaceutical compositions.

摘要翻译： 本发明尤其提供式（I）的化合物：（结构上表示）。 还提供含有这些化合物的药物组合物和使用这些化合物或药物组合物治疗或改善受试者的医疗状况的作用的方法。

公开(公告)号：WO2014108629A1

公开(公告)日：2014-07-17

申请号：PCT/FR2014/050017

申请日：2014-01-07

申请人： PHARMASYNTHESE ,  INABATA FRANCE

发明人： LE ROY, Pierre-Yves ,  LE GUEN, Yves

IPC分类号： C07D309/40 ,  C07C69/618 ,  C07C323/20 ,  C07C235/34 ,  C07C235/38 ,  C07D209/16 ,  C07D211/06 ,  C07D295/192 ,  A61Q19/08 ,  A61K31/216 ,  A61P17/00

CPC分类号： A61Q19/06 ,  A61K8/36 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K8/492 ,  A61K8/4926 ,  A61K8/498 ,  A61K2800/78 ,  A61Q19/02 ,  A61Q19/08 ,  C07C69/734 ,  C07C235/34 ,  C07C235/36 ,  C07C235/38 ,  C07C323/19 ,  C07C2601/02 ,  C07C2601/14 ,  C07D209/16 ,  C07D211/06 ,  C07D265/30 ,  C07D295/192 ,  C07D309/40

摘要： La présente invention a pour objet un composé de formule générale (I) ainsi que son sel pharmaceutiquement acceptable, et l'utilisation de ce composé pour des applications cosmétiques ou pharmaceutiques.

摘要翻译： 本发明涉及具有通式（I）的化合物及其药学上可接受的盐，以及所述化合物在化妆品或药物用途中的用途。