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    TREATMENT OF EXCESSIVE RADIATION (E.G. SUNBURN) EXPOSURE
    91.
    发明申请
    TREATMENT OF EXCESSIVE RADIATION (E.G. SUNBURN) EXPOSURE 审中-公开

    公开(公告)号：WO2003022217A3

    公开(公告)日：2003-03-20

    申请号：PCT/US2002/028692

    申请日：2002-09-06

    Applicant: SYNZYME TECHNOLOGIES LLC

    Inventor： HSIA, Jen-Chang ,  MA, Li

    IPC: A61K7/42

    Abstract: A method is disclosed whereby a formulation is applied to the skin of a patient which may be a human. The formulation is comprised of a carrier and a compound which has a first lipid solubility and a first aqueous solubility. The compound is allowed to permeate the patient's skin and reach viable cells and react in the presence of enzymes of the cells. The reaction results in a compound which has a second lipid solubility which is substantially less than the first lipid solubility and also obtain a second aqueous solubility which is substantially greater than the first aqueous solubility thereby allowing the compound to permeate to viable cells and remain in contact with those cells. The compound may be a nitroxide which aids in modulating adverse effects of reactive oxygen species.

    INFUSING DRUG SOLUTION DIRECTLY INTO BRAIN FLUID
    93.
    发明申请
    INFUSING DRUG SOLUTION DIRECTLY INTO BRAIN FLUID 审中-公开

    公开(公告)号：WO2020149993A1

    公开(公告)日：2020-07-23

    申请号：PCT/US2019/068592

    申请日：2019-12-26

    Applicant: CEREBRAL THERAPEUTICS LLC

    Inventor： ABRAMS, Daniel J. ,  CANNEY, Michael S.

    IPC: A61K9/00 ,  A61K31/197 ,  A61K45/06 ,  A61M25/00 ,  A61P25/08

    Abstract: A method of treating a subject which may be a human suffering from epilepsy which may be a form of epilepsy resistant to treatment and particular patients which are resistant to treatment with oral medication. The method involves positioning a catheter device in the subject's brain and infusing a liquid formulation of a drug into a portion of the subject's brain through an infusion lumen at a rate of 5, 4, 3, 2, or 1 ml or less per day ±50%. The infusion may be constant and corrected by aspirating fluid from the patient's brain and testing the aspirated fluid for drug concentration. The rate of infusion by the formulation and the concentration of drug may be adjusted based on patient responsiveness.

    A METHOD OF TREATING REFRACTORY EPILEPSY SYNDROMES USING FENFLURAMINE ENANTIOMERS
    94.
    发明申请
    A METHOD OF TREATING REFRACTORY EPILEPSY SYNDROMES USING FENFLURAMINE ENANTIOMERS 审中-公开

    公开(公告)号：WO2020112460A1

    公开(公告)日：2020-06-04

    申请号：PCT/US2019/062432

    申请日：2019-11-20

    Applicant: ZOGENIX INTERNATIONAL LIMITED ,  MARTIN, Parthena

    Inventor： MARTIN, Parthena

    IPC: C09K19/38 ,  C09K19/58 ,  G02B5/30

    Abstract: Methods of treating intractable epilepsy syndromes by administering a therapeutically effective dose of a therapeutic agent consisting essentially of a single fenfluramine enantiomer which can be either levofenfluramine or dexfenfluramine, are provided. Intractable epilepsy syndromes for which the present invention finds use include but are not limited to Dravet syndrome, Lennox-Gastaut syndrome, Doose syndrome, West syndrome and refractory seizures. Also provided are methods of treating a neurodegenerative disease in a subject in need thereof. Pharmaceutical compositions for use in practicing the subject methods are also provided.

    ANTIGEN-BINDING PROTEINS TO MARINOBUFAGENIN
    96.
    发明申请
    ANTIGEN-BINDING PROTEINS TO MARINOBUFAGENIN 审中-公开
    抗原结合蛋白到马林布格宁

    公开(公告)号：WO2017015472A1

    公开(公告)日：2017-01-26

    申请号：PCT/US2016/043360

    申请日：2016-07-21

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： DUNN, Michael ,  MORTON, Lori C. ,  RAY, Yonaton ,  KIM, Jee H.

    IPC: C07K16/26 ,  A61K39/00

    CPC classification number: C07K16/26 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

    Abstract: The present invention provides monoclonal antigen-binding proteins that bind to the cardiac glycoside marinobufagenin (MBG), and methods of use. In various embodiments of the invention, the antigen-binding proteins are fully human antigen-binding proteins that bind to MBG. In some embodiments, the antigen-binding proteins of the invention are useful for inhibiting or neutralizing MBG activity, thus providing a means of treating or preventing a MBG-associated disease or disorder selected from the group consisting of hypertension, myocardial fibrosis, uremic cardiomyopathy, heart failure, myocardial infarction, renal failure, renal fibrosis and pre-eclampsia.

    Abstract translation: 本发明提供了结合强心苷甙蛋白原基因（MBG）的单克隆抗原结合蛋白及其使用方法。 在本发明的各种实施方案中，抗原结合蛋白是与MBG结合的完全人抗原结合蛋白。 在一些实施方案中，本发明的抗原结合蛋白可用于抑制或中和MBG活性，从而提供治疗或预防选自以下的MBG相关疾病或病症的方法：高血压，心肌纤维化，尿毒症性心肌病， 心力衰竭，心肌梗塞，肾衰竭，肾纤维化和先兆子痫。

    LIPOSOMES THAT FORM DRUG NANOCRYSTALS AFTER FREEZE-THAW
    99.
    发明申请
    LIPOSOMES THAT FORM DRUG NANOCRYSTALS AFTER FREEZE-THAW 审中-公开
    在冷冻之后形成药物纳米颗粒的脂质体

    公开(公告)号：WO2015156904A1

    公开(公告)日：2015-10-15

    申请号：PCT/US2015/015433

    申请日：2015-02-11

    Applicant: ARADIGM CORPORATION

    Inventor： CIPOLLA, David ,  GONDA, Igor

    IPC: A61K9/19 ,  A61K9/127 ,  A61K9/133

    CPC classification number: A61K9/127 ,  A61K9/0078 ,  A61K31/496 ,  A61K45/06 ,  A61K47/26 ,  Y02A50/406

    Abstract: Methods for formulating a liposome comprised of a surfactant and a cryopreservative that can be frozen for long term stability, and upon thawing provides an immediate and sustained release delivery profile. Specific liposome formulations include anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

    Abstract translation: 用于配制脂质体的方法由表面活性剂和可冷冻长期稳定的冷冻保存剂组成，并且在解冻时提供即时和持续的释放递送特征。 具体的脂质体制剂包括抗感染剂和其用于治疗呼吸道感染和其它医学病症的递送，以及与此相关的用途的装置和制剂。

    KITS FOR DRUG DELIVERY SITE PREPARATION
    100.
    发明申请
    KITS FOR DRUG DELIVERY SITE PREPARATION 审中-公开
    用于药物递送站点准备的药盒

    公开(公告)号：WO2015153900A1

    公开(公告)日：2015-10-08

    申请号：PCT/US2015/024118

    申请日：2015-04-02

    Applicant: ZOGENIX, INC.

    Inventor： BLUMENFELD, Andrew Michael ,  BOYD, Brooks M. ,  SCHUSTER, Jeffrey A. ,  TURANIN, John

    IPC: A61M5/19 ,  A61M5/42 ,  A61M5/178

    CPC classification number: A61M5/178 ,  A61M5/19 ,  A61M5/2053 ,  A61M5/30 ,  A61M5/42 ,  A61M5/425 ,  A61M35/00

    Abstract: Apparatuses and methods for preparing an injection site on a target organ for enhanced delivery are described. In one embodiment, a drug delivery device, such as an injector, is supplied in a kit with an applicator for topically applied drugs, including anesthetics, vasodilators, and/or absorption enhancers. The applicator may be combined with another function, such as a needle or orifice cap. In another embodiment, the delivery system is supplied with an alignment ring, gripper, or vacuum cup to ensure the delivery device is in contact with and at the desired angle relative to the target organ, and ensures that the delivery device does not move relative to the delivery site during delivery. Also disclosed are topical applicators and topical formulations.

    Abstract translation: 描述了用于在目标器官上制备用于增强递送的注射部位的装置和方法。 在一个实施例中，诸如注射器之类的药物输送装置以包含麻醉剂，血管扩张剂和/或吸收促进剂的局部应用药物的施用器的套件供应。 该涂药器可以与另一种功能相结合，例如针头或喷口帽。 在另一个实施例中，输送系统被提供有对准环，夹具或真空杯以确保输送装置与目标器官相接触并且处于期望的角度，并且确保输送装置不会相对于 交货期间的交货地点。 还公开了局部涂药器和局部制剂。

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