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    INHALED SURFACTANT-MODIFIED LIPOSOMAL FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE
    3.
    发明申请
    INHALED SURFACTANT-MODIFIED LIPOSOMAL FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE 审中-公开
    补充的表面活性剂修饰的脂质体制剂提供立即和持续的释放特征

    公开(公告)号：WO2015061025A1

    公开(公告)日：2015-04-30

    申请号：PCT/US2014/059092

    申请日：2014-10-03

    Applicant: ARADIGM CORPORATION

    Inventor： CIPOLLA, David ,  GONDA, Igor

    IPC: A61K9/127

    CPC classification number: A61K9/127 ,  A61K9/0078 ,  A61K31/496 ,  A61K47/10 ,  A61K47/26

    Abstract: Methods for formulating and compositions of immediate and sustained release liposomal products which comprise a surfactant that interacts with liposomes to effect drug release therefrom, and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

    Abstract translation: 用于配制和立即和持续释放的脂质体产品的组合物的方法，其包含与脂质体相互作用以实现药物释放的表面活性剂，以及用于治疗呼吸道感染和其它医学病症的递送剂，以及与其结合使用的装置和制剂 被描述。

    NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHODS FOR THEIR USE
    4.
    发明申请
    NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHODS FOR THEIR USE 审中-公开
    NICOTINE配方，套件及系统及其使用方法

    公开(公告)号：WO2008069970A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007/024636

    申请日：2007-11-30

    Applicant: ARADIGM CORPORATION ,  GONDA, Igor

    Inventor： GONDA, Igor

    IPC: A61K31/465 ,  A61K9/127 ,  A61P43/00

    CPC classification number: A61K31/465 ,  A61K9/0058 ,  A61K9/008 ,  A61K9/7023

    Abstract: This invention relates generally to formulations, compositions, aerosols and kits used to provide habitual tobacco users with products, methods and apparatus to reduce and eventually terminate their dependence on nicotine containing products. More specifically, the invention relates to a nicotine-based medicament and dosage forms thereof formulated in such a way as to effectively reduce or eliminate the sensations of craving associated with addictive nicotine use.

    Abstract translation: 本发明一般涉及用于向习惯性烟草使用者提供产品，方法和装置以减少并最终终止其对含尼古丁产品的依赖性的制剂，组合物，气溶胶和试剂盒。 更具体地说，本发明涉及一种基于尼古丁的药物及其剂型，以有效地减少或消除与上瘾的尼古丁使用相关的渴望的感觉。

    LIPOSOMES THAT FORM DRUG NANOCRYSTALS AFTER FREEZE-THAW
    5.
    发明申请
    LIPOSOMES THAT FORM DRUG NANOCRYSTALS AFTER FREEZE-THAW 审中-公开
    在冷冻之后形成药物纳米颗粒的脂质体

    公开(公告)号：WO2015156904A1

    公开(公告)日：2015-10-15

    申请号：PCT/US2015/015433

    申请日：2015-02-11

    Applicant: ARADIGM CORPORATION

    Inventor： CIPOLLA, David ,  GONDA, Igor

    IPC: A61K9/19 ,  A61K9/127 ,  A61K9/133

    CPC classification number: A61K9/127 ,  A61K9/0078 ,  A61K31/496 ,  A61K45/06 ,  A61K47/26 ,  Y02A50/406

    Abstract: Methods for formulating a liposome comprised of a surfactant and a cryopreservative that can be frozen for long term stability, and upon thawing provides an immediate and sustained release delivery profile. Specific liposome formulations include anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

    Abstract translation: 用于配制脂质体的方法由表面活性剂和可冷冻长期稳定的冷冻保存剂组成，并且在解冻时提供即时和持续的释放递送特征。 具体的脂质体制剂包括抗感染剂和其用于治疗呼吸道感染和其它医学病症的递送，以及与此相关的用途的装置和制剂。

    PH-MODULATED FORMULATIONS FOR PULMONARY DELIVERY
    6.
    发明申请
    PH-MODULATED FORMULATIONS FOR PULMONARY DELIVERY 审中-公开
    用于脉冲递送的PH调制配方

    公开(公告)号：WO2010096242A1

    公开(公告)日：2010-08-26

    申请号：PCT/US2010/022071

    申请日：2010-01-26

    Applicant: ARADIGM CORPORATION ,  CIPOLLA, David C. ,  GONDA, Igor

    Inventor： CIPOLLA, David C. ,  GONDA, Igor

    IPC: A61K9/12

    CPC classification number: A61K31/496 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/12 ,  A61K31/43 ,  A61K31/545 ,  A61K31/65 ,  A61K33/24

    Abstract: An aerosolizable formulation comprised of a drug, a carrier and pH affecting component is disclosed. The drug is dissolved in the formulation at a concentration above which it remains in solution at neutral pH. This increases the concentration of the drug in solution making it possible to administer larger amounts of drug with the same or a smaller volume of formulation. When the formulation is aerosolized to small particles and inhaled into human lungs in small volumes (e.g. 0.05 to 0.5 mL) the fluids in the lungs neutralize the formulation causing the drug to participate out of solution. This results in the drug being delivered at a controlled rate below the rate at which drug is administered from a formulation initially at a neutral pH.

    Abstract translation: 公开了由药物，载体和pH影响组分组成的可雾化制剂。 将药物溶解在制剂中，浓度高于其，在中性pH下保留在溶液中。 这增加了溶液中药物的浓度，使得可以以相同或更小体积的制剂施用更大量的药物。 当将制剂雾化成小颗粒并以小体积（例如0.05至0.5mL）吸入人肺中时，肺中的流体中和制剂，导致药物从溶液中参与。 这导致以最初在中性pH下的制剂以低于药物施用速率的受控速率递送药物。

    SYSTEMS FOR EFFECTING CESSATION OF TOBACCO USE
    8.
    发明申请
    SYSTEMS FOR EFFECTING CESSATION OF TOBACCO USE 审中-公开
    有效减少烟草使用的系统

    公开(公告)号：WO2008069972A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007/024641

    申请日：2007-11-30

    Applicant: ARADIGM CORPORATION ,  GONDA, Igor

    Inventor： GONDA, Igor

    IPC: A61K31/465 ,  A61K9/127 ,  A61P43/00

    CPC classification number: A61K31/465 ,  A61K9/0058 ,  A61K9/008 ,  A61K9/7023

    Abstract: The invention relates generally to a system, kit and method for treating conditions responsive to nicotine therapy. More specifically, the invention relates to pulmonary administration of a nicotine containing formulation to effect smoking cessation.

    Abstract translation: 本发明一般涉及用于治疗对尼古丁治疗有反应的病症的系统，试剂盒和方法。 更具体地说，本发明涉及含尼古丁制剂的肺部给药以实现戒烟。

    AEROSOL GENERATION USING STERILE MULTIPLE DOSE CONTAINERS
    9.
    发明申请
    AEROSOL GENERATION USING STERILE MULTIPLE DOSE CONTAINERS 审中-公开
    使用无菌多剂量容器的航空发动机

    公开(公告)号：WO2002074375A1

    公开(公告)日：2002-09-26

    申请号：PCT/US2002/008628

    申请日：2002-03-19

    Applicant: ARADIGM CORPORATION ,  GONDA, Igor

    Inventor： GONDA, Igor

    IPC: A61M15/00

    CPC classification number: A61M15/0028 ,  A61J1/20 ,  A61M15/0033 ,  A61M15/0066 ,  A61M15/0085

    Abstract: A system for generating aerosol, comprises a multiple-dose container (44), a device for aerosol generation (14), with a means for delivering the aerosol (43) and a disposable package (1) comprising single doses of medicament. The package having a means for drug uptake (52), loadable onto the device and filled with medicament from the multi-dose container.

    Abstract translation: 一种用于产生气溶胶的系统，包括多剂量容器（44），用于产生气溶胶的装置（14），具有用于输送气溶胶的装置（43）和包含单剂量药物的一次性包装（1）。 该包装具有药物摄取装置（52），可装载到装置上并从多剂量容器中填充药物。

    AN ANTIBIOTIC FORMULATION FOR USE IN TREATING BRONCHIECTASIS
    10.
    发明申请
    AN ANTIBIOTIC FORMULATION FOR USE IN TREATING BRONCHIECTASIS 审中-公开

    公开(公告)号：WO2020167429A1

    公开(公告)日：2020-08-20

    申请号：PCT/US2020/014584

    申请日：2020-01-22

    Applicant: ARADIGM CORPORATION

    Inventor： GONDA, Igor ,  SIEBERT, John

    IPC: A61K31/155 ,  A61K9/00

    Abstract: An antibiotic formulation for use in treating a subject diagnosed with bronchiectasis and chronic respiratory bacterial infections, with at least one strain of a bacteria such as Pseudomonas aeruginosa bacteria in an airway sample taken from the subject; the use comprising (a) administering to the subject over a plurality of days (such as 28 days) by inhalation a formulation comprised of the un-encapsulated and encapsulated antibiotic, such as ciprofloxacin; (b) discontinuing the administering over a plurality of days; (c) repeating the administering over a plurality of days; (d) whereby an antibacterial impact of the formulation on the bacteria is not decreased with each repeating step (c).

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