公开(公告)号：WO2011069117A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058974

申请日：2010-12-03

Applicant: NEOSTEM, INC. ,  MARASCO, Wayne ,  MEDICETTY, Satish ,  JIANG, Yajuan

Inventor： MARASCO, Wayne ,  MEDICETTY, Satish ,  JIANG, Yajuan

IPC: A01N1/02

CPC classification number: C12N5/0647 ,  C12N5/0665

Abstract: Disclosed is a method for isolating multiple populations of stem cells in at least one step from a peripheral blood sample without using positive selection, therefore enabling a "no-touch" method to isolate different stem cell populations without contaminating the stem cell populations with positive selection agents (e.g., antibodies, etc ) In particular, the present disclosure relates to flow-rate separation of stem cell populations using elutriation (sized-based separation) to negatively exclude cells based on size Different fractions or subfractions comprise an increase in yield of Very Small Embryonic-like Stem cells (VSELs), MSCs or HSCs as compared to non-fractionated apheresis product.

Abstract translation: 公开了一种在不使用阳性选择的情况下在至少一个步骤中从外周血液样品中分离多个干细胞群的方法，因此能够实现“不接触”方法来分离不同的干细胞群体，而不会用阳性选择污染干细胞群体 药剂（例如，抗体等）特别地，本公开涉及使用淘析（基于大小的分离）干细胞群体的流速分离，以基于大小不利地排除细胞。不同的级分或亚级分包括非常高的产量增加 与非分级分离产物相比，小胚胎样干细胞（VSEL），MSC或HSC。

公开(公告)号：WO2011068997A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058770

申请日：2010-12-02

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  ALBERTS, Jay, L. ,  MCINTYRE, Cameron, C.

Inventor： ALBERTS, Jay, L. ,  MCINTYRE, Cameron, C.

IPC: A61N1/00

CPC classification number: A61N1/36103 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36135

Abstract: A system and method may provide for conducting a stimulation of anatomic regions to treat a neuromotor, neurocognitive or neuromotor and neurocognitive disorder, according to which stimulation, motor regions are stimulated, while creep of current to non-motor regions is minimized. Stimulation parameters may be selected based on tests of motor function, tests of cognitive function, and tests of a combination of motor and cognitive functions.

Abstract translation: 系统和方法可以提供用于进行解剖区域的刺激以治疗神经运动，神经认知或神经运动和神经认知障碍，根据该刺激，运动区域被刺激，同时电流到非运动区域的蠕变最小化。 刺激参数可以根据运动功能的测试，认知功能的测试以及运动和认知功能的组合的测试来选择。

公开(公告)号：WO2011063248A8

公开(公告)日：2011-05-26

申请号：PCT/US2010/057453

申请日：2010-11-19

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  ALBERTS, Jay, L. ,  McINTYRE, Cameron, C.

Inventor： ALBERTS, Jay, L. ,  McINTYRE, Cameron, C.

IPC: G09B3/00 ,  G01D3/00

Abstract: A cognitive and/or motor skill testing system and method may include a processor that records respective time information for each of multiple positions of a display device that are traced during administration of a test, that determines speed and/or velocity values based on the recorded time information, and that outputs test result information based on the determined values. The test result information may be based on a comparison between a graphed curve of such values to an ideal curve. The positions may correspond to a path between displayed targets whose size and/or distance therebetween depend on past test performance. The system and/or method may output a change expected with a change to therapy parameters for a patient, where the expected change is determined based on changes which occurred in other patients having similar test results and therapy parameters as those of the patient.

公开(公告)号：WO2010111702A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/029052

申请日：2010-03-29

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  GHEBREHIWET, Berhane

Inventor： GHEBREHIWET, Berhane

IPC: A61P7/00 ,  A61K38/04 ,  A61K39/395

CPC classification number: A61K38/04 ,  C07K7/08 ,  C07K7/18 ,  C07K16/00 ,  C07K2317/76

Abstract: One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gClq-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gClq-R.

Abstract translation: 本发明的一个方面提供一种治疗或预​​防有需要的患者的血管性水肿的方法，包括向患者施用治疗有效量的能够抑制HK与gClq-R相互作用的药剂。 本发明的一个方面提供了治疗或预防有需要的患者的血管通透性的方法，包括向患者施用治疗有效量的能够抑制HK与gClq-R相互作用的药剂。

公开(公告)号：WO2010065551A3

公开(公告)日：2010-06-10

申请号：PCT/US2009/066276

申请日：2009-12-01

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  SITHARAMAN, Balaji ,  GREEN, Danielle, E. ,  LONGTIN, Jon

Inventor： SITHARAMAN, Balaji ,  GREEN, Danielle, E. ,  LONGTIN, Jon

IPC: A01K67/00 ,  C12N5/0775

Abstract: A method for differentiating mesenchymal stem cells (MSCs) towards osteoblasts and other connective tissue using nanoparticles and electromagnetic stimulation Osteoinductive materials produced using said method may be useful for bone regeneration and reconstruction in treatment of bone trauma and bone related diseases, and to correct birth defects.

公开(公告)号：WO2009139909A1

公开(公告)日：2009-11-19

申请号：PCT/US2009/003040

申请日：2009-05-15

Applicant: INTELECT MEDICAL, INC. ,  KOKONES, Scott ,  BLUM, David, Arthur ,  CARLTON, Ketih ,  SPARKS, Troy

Inventor： KOKONES, Scott ,  BLUM, David, Arthur ,  CARLTON, Ketih ,  SPARKS, Troy

IPC: A61N1/372

CPC classification number: A61N1/36128 ,  A61B5/055 ,  A61B34/10 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2090/103 ,  A61N1/36082 ,  A61N1/36185 ,  A61N1/37247 ,  G06F19/00 ,  G06F19/325 ,  G06K9/00885 ,  G16H40/63 ,  G16H50/50

Abstract: A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.

Abstract translation: 用于选择用于深脑刺激（DBS）的刺激参数的系统和方法可以包括显示在显示装置中并且涉及包括模型电极的引线的显示模型的处理器，对应于第一刺激参数组的当前场 提供用于接收表示当前场的移位的用户输入的用户界面，响应于用户输入，在显示设备中相对于所显示的模型移动当前场，确定结果的第二刺激参数集 并且输出所述第二刺激参数集和/或设置具有所述第二刺激参数集的刺激装置，其中所述刺激装置被配置为根据所述第二刺激参数集执行使用所述引线的刺激。

公开(公告)号：WO2008121992A2

公开(公告)日：2008-10-09

申请号：PCT/US2008/058952

申请日：2008-03-31

Applicant: RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  WIMMER, Eckhard ,  SKIENA, Steve ,  MUELLER, Steffen ,  FUTCHER, Bruce ,  PAPAMICHAIL, Dimitris ,  COLEMAN, John, Robert

Inventor： WIMMER, Eckhard ,  SKIENA, Steve ,  MUELLER, Steffen ,  FUTCHER, Bruce ,  PAPAMICHAIL, Dimitris ,  COLEMAN, John, Robert

IPC: A61K39/13

CPC classification number: C12N7/00 ,  A61K39/13 ,  A61K39/145 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2720/12361 ,  C12N2740/15061 ,  C12N2760/16061 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16162 ,  C12N2770/20061 ,  C12N2770/24161 ,  C12N2770/32061 ,  C12N2770/32621 ,  C12N2770/32634 ,  C12N2770/32661 ,  C12N2770/32662 ,  C12N2770/32671 ,  C12N2770/32721 ,  C12N2770/32761 ,  C12N2770/32762 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/466

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract translation: 本发明提供了一种减毒病毒，其包含修饰的病毒基因组，其含有在基因组中的多个位置工程改造的核苷酸取代，其中所述取代将同义脱酮密码子引入基因组。 本发明的减毒病毒可用于疫苗组合物中以在受试者中诱导保护性免疫应答。 本发明还提供合成即时减毒病毒的方法。 此外，本发明进一步提供了一种防止受试者患有病毒相关疾病的方法，包括向受试者施用预防有效剂量的包含即时减毒病毒的疫苗组合物。

公开(公告)号：WO2006116019A3

公开(公告)日：2006-11-02

申请号：PCT/US2006/014984

申请日：2006-04-21

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  PILE-SPELLMAN, John ,  LEI, Feng

Inventor： PILE-SPELLMAN, John ,  LEI, Feng

IPC: A61M25/00

Abstract: The present invention provides endovascular brushes that include a brush segment at the distal end and a mandrel segment extending from the brush segment to the proximal end of the endovascular brush. The brush segment includes at least brush element, such as a fiber, bristle, loop, ridge, or corrugation, configured to provide a space or spaced for retaining cells biopsied with the endovascular brush and to reduce the thrombogenicity of the endovascular brush, which allows a user to safely obtain therewith endovascular tissue from a targeted vascular segment in-vivo .

公开(公告)号：WO2006009694A2

公开(公告)日：2006-01-26

申请号：PCT/US2005/020969

申请日：2005-06-14

Applicant: IMCLONE SYSETMS INCORPORATED ,  THE UNIVERSITY OF PENNSYLVANIA ,  KUSSIE, Paul, H. ,  FERGUSON, Kathryn, M.

Inventor： KUSSIE, Paul, H. ,  FERGUSON, Kathryn, M.

IPC: C07K14/71

CPC classification number: C07K14/71 ,  C07K2299/00

Abstract: The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.

Abstract translation: 本发明涉及在与EGFR细胞外结构域的复合体中的西妥昔单抗Fab的共晶体，以及由该晶体得到的结构坐标。 这种坐标可用于鉴定结合EGFR细胞外结构域的模拟物。 这种模拟物可以例如抑制配体与EGFR的结合，抑制EGFR的激活和/或降低肿瘤细胞的增殖。