公开(公告)号：WO2023003998A1

公开(公告)日：2023-01-26

申请号：PCT/US2022/037803

申请日：2022-07-21

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： JOHNSTON, Douglas ,  QUINTINI, Cristiano ,  SOLTESZ, Edward ,  ROMERO, Jose ,  KOLOSI, William ,  KADAVY, Thomas

IPC: G06V10/82 ,  G06V10/143

Abstract: The present disclosure relates to a system and method for recognizing objects used in a medical procedure using a convolutional neural network. No database of image information for such objects is used or required. Rather, the neural network is trained to recognize the objects, and does not require any such image database. The system is able to reconcile the recognized objects against a 'counted-in' list of objects for the procedure, to ensure that all such objects are accounted for prior to closing the procedure.

公开(公告)号：WO2022245890A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/029754

申请日：2022-05-18

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  NEW COS INC., D/B/A VISIONAIR SOLUTIONS

Inventor： GILDEA, Thomas ,  GRAFMEYER, Keith ,  EVA, Jake ,  LIBERTOWSKI, Kevin ,  BECKREST, Brian ,  BLACKISTON, Tyler

IPC: A61F2/82 ,  A61B17/12 ,  A61F2/04

Abstract: A bronchial stent includes a first branch configured to widen, open, and/or mechanically support a first airway; an obstructive portion that, when the stent is deployed in the first airway, obstructs a second airway, the second airway forming a branching connection with the first airway; and a feature proximal to the obstructive portion, the feature configured to facilitate opening of the obstructive portion.

公开(公告)号：WO2022225719A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/023854

申请日：2022-04-07

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： FLEISCHMAN, Aaron

IPC: B06B1/02 ,  B06B1/06 ,  H01L41/193 ,  H01L41/333

Abstract: High-resolution intravascular ultrasound (H-IVUS) operates under a large acoustic bandwidth, provides high resolution while maintaining good depth penetration, and exhibits other favorable characteristics like focused imaging. A H-IVUS transducer assembly can be manufactured at a low cost using conventional methods commonly utilized in the microelectronics industry. The H-IVUS transducer assembly can include a printed circuit having one or more electrical signal conditioners. One or more convertors made of a polymer and configured to convert electrical energy to acoustic energy and acoustic energy to electrical energy can be formed in place away from the printed circuit. After construction, the one or more formed in place convertors are interfaced to the printed circuit with at least a conductive material.

公开(公告)号：WO2022159153A1

公开(公告)日：2022-07-28

申请号：PCT/US2021/055349

申请日：2021-10-18

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： LAL, Dennis

IPC: G16B15/00 ,  G16B20/00

Abstract: Methods for identification of essential sites in a protein structure is disclosed. The method includes steps of: (1) mapping sequence-based conservation scores across human paralogs (Paraz) and missense tolerance ratio (MTR) for a plurality of amino acid residues of a protein onto a protein structure of the protein; (2) identifying three-dimensional (3D) structural sites of the protein structure that are relatively conserved across paralogs and intolerant for missense variants based on the Paraz and MTR scores; (3) detecting pathogenic variant enriched residues (PER3D) for the identified 3D structural sites of the protein structure, (4) determining essential 3D sites of the protein structure based on the detected PER3D; and (5) mapping the determined essential 3D sites to a gene sequence that encodes the protein. Methods for predicting a pathology of a patient and for synthesizing a gene for use in gene therapy also are disclosed.

公开(公告)号：WO2022035728A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/045153

申请日：2021-08-09

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： NAVIA, Jose ,  KAPADIA, Samir ,  HOVEST, Torey ,  GEOFFRION, Richard ,  FARNAN, Robert

IPC: A61F2/24

Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve includes at least one subvalvular device including a subvalvular supporting portion and an anchor portion. The subvalvular supporting portion and anchor portion are each at least partially formed from at least one of braided mesh strands of a first configuration, braided mesh strands of a second configuration, a balloon, a plurality of longitudinally extending struts, and a plurality of laterally extending struts. A connector neck is interposed longitudinally between, and is attached to both of, the subvalvular supporting portion and the anchor portion. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

公开(公告)号：WO2021151033A1

公开(公告)日：2021-07-29

申请号：PCT/US2021/014804

申请日：2021-01-23

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： ROSELLI, Eric, E.

IPC: A61F2/07 ,  A61F2/06 ,  A61F2002/061 ,  A61F2002/067 ,  A61F2250/0062

Abstract: A stent graft configured to facilitate the placement of a secondary stent is provided and a method thereof. The stent graft can include an elongated body with a frame structure, a lumen, and apertures at both ends of the elongated body. The frame structure can be covered by a graft material. At least one station can be located in the graft material. The at least one station has a perimeter defined by a ring structure connected to the graft material and an aperture bounded by the perimeter. The aperture can be covered by graft material. The at least one station can be fenestrated to facilitate placement of a secondary stent.

公开(公告)号：WO2021118933A1

公开(公告)日：2021-06-17

申请号：PCT/US2020/063630

申请日：2020-12-07

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： MCCURRY, Kenneth ,  BASHOUR, Allen ,  HOVEST, Torey ,  KNOWLTON, Christopher ,  SHOREY, Frederick A.

IPC: A61M25/00 ,  A61M25/01 ,  A61M1/00 ,  A61M1/36 ,  A61M1/28

Abstract: A cannula apparatus (100) and method are provided for selective fluid flow in removal and return directions. An outer sheath (102) has proximal (104) and distal (106) outer sheath ends spaced apart by a longitudinal outer sheath body (108) defining an outer sheath lumen (110). At least one fluid removal aperture (112) extends through the outer sheath body. The outer sheath includes a side access aperture (114). An introducer (1534) has proximal (1536) and distal (1538) introducer ends spaced apart by a longitudinal introducer body (1540), which at least partially defines a guidewire channel (1542) longitudinally therealong. The introducer is configured for insertion into the outer sheath lumen with the guidewire channel in fluid communication with the side access aperture. An inner tube (218) has proximal (220) and distal (222) inner tube ends. At least one fluid return aperture (228) is located at least one of at and adjacent the distal inner tube end to place an inner tube lumen in fluid communication with an ambient space.

公开(公告)号：WO2021032441A1

公开(公告)日：2021-02-25

申请号：PCT/EP2020/071658

申请日：2020-07-31

Applicant: SIEMENS HEALTHCARE GMBH ,  THE CLEVELAND CLINIC FOUNDATION

Inventor： DIETRICH, Carsten ,  SIEBERT, Matthias ,  ABAZEED, Mohamed ,  GEORGI, Jens-Christoph ,  WEHNER, Heike ,  KAPPEL, Andreas ,  MATZAS, Mark ,  POSCH, Andreas Emanuel

IPC: C12Q1/6886

Abstract: The present invention relates to methods of predicting a radiotherapy success in a method of treating a lung cancer of a patient, the use of specific markers for predicting a radiotherapy success in a method of treating a lung cancer of a patient, a database comprising the markers, and a computer program product for use in such a method.

公开(公告)号：WO2020243390A1

公开(公告)日：2020-12-03

申请号：PCT/US2020/035063

申请日：2020-05-29

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： KRISHNA, Vijay

IPC: A61K41/00 ,  A61K47/06 ,  A61N5/067 ,  B82Y30/00 ,  C01B32/152

Abstract: Provided herein are compositions, systems, kits, and methods for administering a gel composition into a tumor of a subject and treating with laser light (e.g., for photoacoustic destruction of the tumor and tumor debris generation), where the gel comprises functionalized fullerenes (FFs) and a biocompatible polymer. In certain embodiments, 0.1-5% (e.g., about 1-2%) by weight of the gel is the functionalized fullerenes (e.g . , polyhydroxy fullerenes). In other embodiments, the FFs have a generally symmetrical spherical structure.

公开(公告)号：WO2020237141A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/034201

申请日：2020-05-22

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： JENSEN, Jan ,  BUKYS, Michael A.

IPC: C07K14/475 ,  C07K14/51 ,  C12N5/00

Abstract: Provided herein are compositions, systems, kits, and methods for generating dorsal foregut endoderm (DFE) cells by contacting pluripotent stem cells with a retinoic acid signaling pathway agonist and a bone morphogenetic (BMP) pathway inhibitor without exposing the stem cells to a transforming growth factor beta (TGFβ) pathway agonist. In certain embodiments, the DFE cells are contacted with a retinoic acid signaling pathway agonist and a FGFR pathway inhibitor to generate pancreatic endoderm (PE) cells (e.g., with dorsal identity). In other embodiments, the PE cells are contacted with an ALK5 inhibitor and a Notch inhibitor to generate endocrine cells (e.g., insulin expressing endocrine cells). In certain embodiments, compositions, systems, kits, and methods are provided for generating anterior domain endoderm (ADE) cells.