公开(公告)号：WO2019006178A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/040106

申请日：2018-06-28

Applicant: HI LLC

Inventor： LARA, Antonio, H. ,  SANDLER, Roman ,  ROBINSON, Brian, S. ,  ANDERSON, Kristopher ,  WENTZ, Christian ,  KOENE, Randal ,  STANTON, John, W. ,  PETERSON, Erik, J.

IPC: A61N2/00 ,  A61N1/00

CPC classification number: A61N1/0534 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/048 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/7225 ,  A61B5/7257 ,  A61N1/0531 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/37252 ,  A61N1/3787

Abstract: Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.

公开(公告)号：WO2018118928A2

公开(公告)日：2018-06-28

申请号：PCT/US2017/067326

申请日：2017-12-19

Applicant: DECURION, LLC

Inventor： PEREZ, Raul, E. ,  HOGG, Bevil

IPC: A61N1/02

CPC classification number: A61N1/36034 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0521 ,  A61N1/36007 ,  A61N1/36082 ,  A61N1/36171

Abstract: System and method focused on reversing the erectile dysfunction condition through a long term therapy is disclosed. The system comprises wirelessly controlled contact electrodes that are positioned in contact with the outer surface of the penis and/or the pelvic floor area to stimulate certain vital parts which have a significant role in enabling the erectile function of penis. Contact electrodes are powered through wireless transmission of energy. Regeneration of the smooth muscle mass in corpora cavernosa and the pelvic floor area is achieved through long term therapeutic treatment. The device can also be used in preventing reduction in the existing level of smooth muscle mass in penis.

公开(公告)号：WO2017223430A1

公开(公告)日：2017-12-28

申请号：PCT/US2017/038974

申请日：2017-06-23

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： ESKANDAR, Emad, N. ,  WIDGE, Alik, S. ,  DOUGHERTY, Darin, D. ,  LO, Meng-Chen ,  BASU, Ishita

IPC: A61B5/00 ,  A61N1/32 ,  A61N1/36 ,  A61N1/04 ,  A61N1/00

CPC classification number: A61N1/36082 ,  A61B5/04012 ,  A61N1/0534 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/36146 ,  A61N1/36153 ,  A61N1/36171 ,  A61N1/36178

Abstract: Systems and methods for controlling brain activity are provided. In some aspects, a method for controlling a synchrony in brain activity of a subject is provided. The method includes positioning stimulators to stimulate a first region and a second region of a subject's brain, and selecting a pulsed stimulation sequence comprising a first stimulation to the first region and a second stimulation to the second region, wherein the stimulations are timed to be substantially concurrent and separated by a phase lag. The method also includes delivering the pulsed stimulation sequence, using the stimulators, to control a synchrony between the first region and the second region at a predetermined frequency.

Abstract translation: 提供了用于控制大脑活动的系统和方法。 在一些方面中，提供了一种用于控制对象的大脑活动的同步的方法。 该方法包括定位刺激器以刺激对象大脑的第一区域和第二区域，并且选择包括对第一区域的第一刺激和对第二区域的第二刺激的脉冲刺激序列，其中刺激被定时为基本上 并发和相位滞后分开。 该方法还包括使用刺激器递送脉冲刺激序列，以预定频率控制第一区域和第二区域之间的同步。

公开(公告)号：WO2016134271A1

公开(公告)日：2016-08-25

申请号：PCT/US2016/018700

申请日：2016-02-19

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MILLER, Earl K. ,  BRINCAT, Scott L.

IPC: A61N1/36

CPC classification number: A61N1/36082 ,  A61N1/0456 ,  A61N1/0529 ,  A61N1/36025 ,  A61N1/36146 ,  A61N1/36196 ,  A61N1/37247

Abstract: Systems and methods are disclosed for selectively reinforcing or weakening memory associations. At least one current generator provides an electrical current including a plurality of oscillating pulses with at least one predetermined frequency. A user interface includes at least one output device for delivering a sensory stimulus to a user and at least one user input device for registering a response to the stimulus. At least one processor determines from the response, based on at least one predetermined standard, whether an underlying memory association is desired or undesired and respectively sets the at least one predetermined frequency to be a beta or theta frequency. Consequently, the electrical current is generated and administered, via at least one electrode pair, thereby stimulating at least one specific portion of the user's brain so as to reinforce or weaken the underlying memory association.

Abstract translation: 公开了用于选择性地增强或削弱记忆关联的系统和方法。 至少一个电流发生器提供包括具有至少一个预定频率的多个振荡脉冲的电流。 用户界面包括用于将感觉刺激传送给用户的至少一个输出设备和用于注册对刺激的响应的至少一个用户输入设备。 至少一个处理器基于至少一个预定标准从响应确定底层存储器关联是期望还是不期望的，并且分别将至少一个预定频率设置为β或θ频率。 因此，通过至少一个电极对产生和施加电流，由此刺激用户脑部的至少一个特定部分，以便加强或削弱下面的记忆关联。

公开(公告)号：WO2016132258A1

公开(公告)日：2016-08-25

申请号：PCT/IB2016/050735

申请日：2016-02-11

Applicant: ARLOTTI, Mattia ,  PRIORI, Alberto ,  ROSSI, Lorenzo

Inventor： ARLOTTI, Mattia ,  PRIORI, Alberto ,  ROSSI, Lorenzo

IPC: A61N1/36 ,  A61B5/00

CPC classification number: A61N1/3606 ,  A61B5/048 ,  A61B5/4076 ,  A61B5/4082 ,  A61B5/4836 ,  A61B5/7257 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36082

Abstract: The present invention concerns an apparatus for treating neurological disorders comprising (i) at least one electrode implantable in the brain of a patient and (ii) a processing and stimulation device connected to the at least one electrode, wherein the processing and stimulation device comprises (a) at least one stimulation module adapted to generate a stimulation signal to be sent to the at least one electrode, the stimulation signal being characterised by a plurality of parameters, (b) at least one acquisition module of a signal characteristic of cerebral activity coming from the brain of the patient adapted to determine its power in at least one frequency band, and (c) at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is such as to set the at least one parameter (Va,Vd,Vf) of the stimulation signal (Vstim) differently dependent on a plurality of power ranges, by keeping the at least one parameter within a predetermined stimulation range ([Vi_HighThreshold;Vi_LowThreshold]) with i = a,d,f.

Abstract translation: 本发明涉及一种用于治疗神经障碍的装置，包括（i）至少一个可植入患者脑部的电极和（ii）连接至该至少一个电极的处理和刺激装置，其中所述处理和刺激装置包括 a）至少一个刺激模块，其适于产生要发送到所述至少一个电极的刺激信号，所述刺激信号由多个参数表征，（b）至少一个具有脑活动特征的信号获取模块 适于确定其在至少一个频带中的功率的患者的脑部，以及（c）至少一个控制模块，所述至少一个控制模块作为所获取的脑活动特征信号的功率的刺激信号的至少一个参数 基于具有饱和趋势的传递函数，其中所述传递函数用于设置所述st的至少一个参数（Va，Vd，Vf） 通过使i = a，d，f中的至少一个参数保持在预定的刺激范围（[Vi_HighThreshold; Vi_LowThreshold]）内，不同地取决于多个功率范围的模拟信号（Vstim）。

公开(公告)号：WO2016071236A1

公开(公告)日：2016-05-12

申请号：PCT/EP2015/075297

申请日：2015-10-30

Applicant: FORSCHUNGSZENTRUM JÜLICH GMBH

Inventor： TASS, Peter, Alexander ,  POPOVYCH, Oleksandr ,  XENAKIS, Markos

IPC: A61N1/36 ,  A61M21/00 ,  A61N2/00 ,  A61B5/00

CPC classification number: A61N1/36025 ,  A61B5/0476 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4082 ,  A61B5/4088 ,  A61B5/4094 ,  A61B5/4836 ,  A61M21/00 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/0055 ,  A61M2021/0066 ,  A61M2021/0072 ,  A61N1/36014 ,  A61N1/3603 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36139 ,  A61N1/36175 ,  A61N1/36178 ,  A61N2/006

Abstract: Die Erfindung betrifft eine Vorrichtung zur Unterdrückung einer krankhaft synchronen und oszillatorischen neuronalen Aktivität, umfassend - eine nicht-invasive Stimulationseinheit zur Stimulation von Neuronen im Hirn und/ oder Rückenmark des Patienten, die eine krankhaft synchrone und oszillatorische neuronale Aktivität aufweisen, mit Reizen, wobei die Reize dazu ausgelegt sind, bei einer Verabreichung an den Patienten die krankhaft synchrone und oszillatorische neuronale Aktivität zu unterdrücken, - eine Messeinheit zum Aufnehmen von Messsignalen, die eine neuronale Aktivität der stimulierten Neuronen wiedergeben, und - eine Steuer- und Analyseeinheit zur Steuerung der Stimulationseinheit und zur Analyse der Messsignale, wobei die Steuer- und Analyseeinheit derart ausgestaltet ist, dass sie - die Stimulationseinheit derart ansteuert, dass die Stimulationseinheit Reize appliziert, - anhand der in Reaktion auf die Applikation der Reize aufgenommenen Messsignale den Stimulationserfolg überprüft, und - falls der Stimulationserfolg nicht ausreichend ist, eine oder mehrere Stimulationspausen in die Applikation der Reize einfügt oder eine oder mehrere Stimulationspausen verlängert, wobei während der Stimulationspausen keine Reize appliziert werden, welche die krankhaft synchrone und oszillatorische neuronale Aktivität unterdrücken könnten.

Abstract translation: 本发明涉及一种用于包括病态同步和振荡神经活动的抑制的装置 - 一种非侵入性的刺激单元，其用于在患者中，其中有一个病态同步和振荡的神经元活性，刺激的脑和/或脊髓的神经元的刺激，所述 刺激适合于抑制病理性同步和振荡的神经元活动时施用于患者， - 测量单元，用于接收表示受刺激神经的神经元活动的测量信号，以及 - 控制和分析单元，用于控制所述刺激单元和 对于测量信号的分析，其中，所述控制和分析单元被设计为使得它 - 控制，使得所述刺激单元施加的刺激，所述刺激单元 - 基于响应于所述刺激信号的测量Stimulationser应用程序所接收到的 成功验证;以及 - 如果所述刺激的成功是不充分的，一个或在刺激或扩展，一个或多个刺激的间隔，其中，在刺激期间暂停没有施加的刺激，这可能抑制病理性同步和振荡的神经元活动的应用程序插入多重刺激暂停。

公开(公告)号：WO2015191628A1

公开(公告)日：2015-12-17

申请号：PCT/US2015/034962

申请日：2015-06-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： FRIED, Itzhak ,  MARKOVIC, Dejan ,  SUTHANA, Nanthia

IPC: A61N1/05

CPC classification number: A61N1/36082 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/6868 ,  A61N1/025 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36092 ,  A61N1/36125 ,  A61N1/36139 ,  A61N1/37229 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

Abstract: Systems and methods for restoring cognitive function are disclosed. In some implementations, a method includes, at a computing device, separately stimulating one or more of lateral and medial entorhinal afferents and other structures connecting to a hippocampus of an animal subject in accordance with a plurality of predefined stimulation patterns, thereby attempting to restore object-specific memories and location-specific memories; collecting a plurality of one or more of macro- and micro-recordings of the stimulation of hippocampalentorhinal cortical (HEC) system; and refining the computational model for restoring individual memories in accordance with a portion of the plurality of one or more of macro- and micro-recordings.

Abstract translation: 公开了恢复认知功能的系统和方法。 在一些实施方式中，一种方法包括在计算设备处，分别刺激根据多个预定义的刺激模式连接到动物对象的海马的侧向和内侧嗅觉传入和其他结构中的一个或多个，从而尝试恢复对象 特定的记忆和位置特定的记忆; 收集海马脑皮层（HEC）系统刺激的多个宏观和微观记录; 以及根据所述多个一个或多个宏和微记录的一部分来细化用于恢复各个存储器的计算模型。

公开(公告)号：WO2015187828A1

公开(公告)日：2015-12-10

申请号：PCT/US2015/033976

申请日：2015-06-03

Applicant: RIDDER, Dirk, De

Inventor： RIDDER, Dirk, De

IPC: A61N1/36

CPC classification number: A61N1/36025 ,  A61N1/36082

Abstract: In embodiments of the present disclosure, methods of treating a neurological disorder comprise providing reconditioning electrical stimulation. The methods may comprise applying electrical stimulation that provides positive reinforcement by activation within the reward network of the brain of the patient when an appropriate external stimulus is provided to the patient. The external stimulus is selected in accordance with the specific neurological disorder being treated in the patient. The methods may comprise applying electrical stimulation that provides negative reinforcement by stimulation of aversion-related locations of the brain of the patient when a different external stimulus is provided to the patient.

Abstract translation: 在本公开的实施方案中，治疗神经障碍的方法包括提供修复电刺激。 所述方法可以包括施加电刺激，所述电刺激通过在向患者提供适当的外部刺激时在患者的脑的奖励网络内激活而提供正增强。 根据患者正在治疗的特定神经系统疾病选择外部刺激。 所述方法可以包括当向患者提供不同的外部刺激时，施加电刺激，所述刺激通过刺激患者的脑的厌恶相关位置来提供负强化。

公开(公告)号：WO2015153675A1

公开(公告)日：2015-10-08

申请号：PCT/US2015/023693

申请日：2015-03-31

Applicant: STUBBEMAN, William, F.

Inventor： STUBBEMAN, William, F.

IPC: A61N2/00 ,  A61N2/02

CPC classification number: A61N2/006 ,  A61B5/0059 ,  A61B5/04008 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/4848 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36082 ,  A61N2/004

Abstract: A therapeutic or diagnostic system comprises a non-invasive brain stimulation device (such as a TMS stimulation device) or other neuromodulation device configured to stimulate a patient's brain or nervous system by emitting electromagnetic pulses according to stimulation parameters, such as a pulse frequency or burst repetition frequency or other parameters, that provides surprising improvements in responsiveness and/or may require only a relatively short train of pulses to achieve high efficacy. In particular, stimulation pulses may be delivered at a frequency of between 12 and 40 Hertz with a 3 to 5 ratio as compared with burst repetition frequency, or at other specific patterns within that range. The stimulation parameters may be pre-stored and customized to individual patients, being identified through an automated search routine during which patient feedback is monitored. A user interface may be provided to allow an operator to conveniently select the appropriate parameters for the desired treatment.

Abstract translation: 治疗或诊断系统包括非侵入性脑刺激装置（例如TMS刺激装置）或其他神经调节装置，其被配置为通过根据刺激参数（例如脉冲频率或脉冲串）发射电磁脉冲来刺激患者的大脑或神经系统 重复频率或其他参数，其在响应性方面提供令人惊讶的改进和/或可能仅需要相对较短的脉冲串来实现高效率。 特别地，与突发重复频率相比，或者在该范围内的其他特定模式下，刺激脉冲可以以12至40赫兹的频率以3比5的比率递送。 刺激参数可以预先存储和定制为个体患者，通过自动搜索例程来识别患者反馈。 可以提供用户界面以允许操作者方便地选择用于期望治疗的适当参数。

公开(公告)号：WO2015100306A1

公开(公告)日：2015-07-02

申请号：PCT/US2014/072112

申请日：2014-12-23

Applicant: DEEP BRAIN INNOVATIONS LLC

Inventor： STROTHER, Robert ,  SAKAI, Jonathan ,  THROPE, Geoffrey

IPC: A61N1/08

CPC classification number: A61N1/37247 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36096 ,  A61N1/36128

Abstract: The present technology provides a medical stimulation system having a clinical programmer configured to operate on a computational and memory device having a wireless communication device. The technology also provides a neurostimulator configured to wirelessly communicate with the clinical programmer. The neurostimulator also includes a pulse generator operatively coupled with an electrode by a lead. The pulse generator is configured to transmit an electrical signal comprising a repeating succession of non-regular pulse trains. Each pulse train includes a plurality of pulses having non-regular, non-random, differing inter-pulse intervals therebetween. The pulse trains repeat in succession to treat a neurological condition. Further, the pulse trains are initiated by instructions communicated by the clinical programmer.

Abstract translation: 本技术提供了一种医疗刺激系统，其具有被配置为在具有无线通信设备的计算和存储设备上操作的临床程序设备。 该技术还提供了配置为与临床程序员无线通信的神经刺激器。 神经刺激器还包括通过引线与电极操作耦合的脉冲发生器。 脉冲发生器被配置为发送包括重复序列的非规则脉冲串的电信号。 每个脉冲串包括在它们之间具有非规则的，非随机的，不同的脉冲间隔的多个脉冲。 脉冲序列连续重复以治疗神经疾病。 此外，脉冲序列由临床程序员传递的指令启动。