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2380 条记录 (耗时 0.017 秒)

    SYSTEM AND METHOD FOR OPTIMIZING PEAK SHAPES
    91.
    发明申请
    SYSTEM AND METHOD FOR OPTIMIZING PEAK SHAPES 审中-公开

    公开(公告)号：WO2019138977A1

    公开(公告)日：2019-07-18

    申请号：PCT/JP2019/000125

    申请日：2019-01-08

    申请人： ATONARP INC.

    发明人： MADATHIL, Karthikeyan Rajan

    IPC分类号： G01N27/62 ,  H01J49/26

    摘要： A system (110) includes a first type of sensor (104) and an estimation system (106) that is connected to first type of sensor (104). The estimation system (106) is configured to (a) identify a best peak shape for estimation of known gas mixtures by analyzing characterization data across known gas mixtures, with added noise, using machine learning, (b) generate a plurality of actual peak shapes, in first type of sensor (104), for several different instances using standard gas mixtures to provide an actual peak shape among the plurality of peak shapes as calibrating input to calibrate first type of sensor (104) and (c) calibrate first type of sensor (104) by automatically adjusting parameters of first type of sensor (104) for optimizing actual peak shape to match with desired peak shape.

    A METHOD OF IDENTIFYING ISOMERS OF CURCUMIN AND PREFERENTIAL STABILISATION OF ONE OF THEM
    93.
    发明申请
    A METHOD OF IDENTIFYING ISOMERS OF CURCUMIN AND PREFERENTIAL STABILISATION OF ONE OF THEM 审中-公开

    公开(公告)号：WO2019097542A1

    公开(公告)日：2019-05-23

    申请号：PCT/IN2018/050749

    申请日：2018-11-14

    申请人： INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IIT MADRAS)

    发明人： PRADEEP, Thalappil ,  NAG, Abhijit ,  CHAKRABORTY, Papri ,  BAKSI, Ananya ,  NATARAJAN, Ganapati

    IPC分类号： C07C49/248 ,  G01N27/62

    摘要： A detailed examination of collision cross sections (CCSs) coupled with computational methods has revealed new insights into some of the key questions centered around curcumin, one of the most intensively studied natural therapeutic agents. In this study, we have distinguished the structures and conformers of the well-known enol and the far more elusive keto form of curcumin by using ion mobility mass spectrometry (IM MS). The values of the theoretically predicted isomers are compared with the experimental CCS values to confirm their structures. We have identified a folded structure for the keto form and the degree of folding is estimated using this method. Using IM MS, we have shown that ESI MS reflects the solution phase structures and their relative populations. The ratio of populations depends on multiple factors which have been examined. Piperine, a naturally occurring heterocyclic compound, is known to increase the bioavailability of curcumin. However, it is still not clearly understood that which tautomeric form of curcumin is better stabilized by it. We have identified preferential stabilization of the enol form in presence of piperine using IM MS. Cyclodextrins (CDs) are used as well-known carriers in the pharmaceutical industry for increased stability, solubility, bioavailability, and tolerability of curcumin. However, the crystal structures of supramolecular complexes of curcumin-cyclodextrin are unknown. We have determined the structures of the different isomers of the curcumin∩cyclodextrin (α- and β-CD) complexes by comparing the CCSs of theoretically predicted structures with the experimentally obtained CCSs, which will further help in understanding the specific role of the structures involved in different biological activities.

    METHOD OF MANUFACTURE FOR AN ION MOBILITY FILTER
    94.
    发明申请
    METHOD OF MANUFACTURE FOR AN ION MOBILITY FILTER 审中-公开

    公开(公告)号：WO2019097234A1

    公开(公告)日：2019-05-23

    申请号：PCT/GB2018/053308

    申请日：2018-11-15

    申请人： OWLSTONE MEDICAL LIMITED ,  OWLSTONE INC.

    发明人： ALLSWORTH, Max ,  MELHIRST, Daniel ,  HART, Matthew

    IPC分类号： G01N27/62 ,  H01J49/00 ,  H01J49/06 ,  H01L21/78

    CPC分类号： G01N27/624

    摘要： A method of manufacture for a ion mobility filter is disclosed. The present techniques relate to a method of manufacturing a MEMS gas sensor, for example, an ion mobility filter which may be used as a field asymmetric ion mobility spectrometry filter. The method of manufacturing an ion filter for a spectrometry system is comprised of providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer (22) for each ion filter on the sheet, wherein each electrode layer (22) comprisesat least one ion channel (28) and an isolation channel (30) surrounding the at least one ion channel (28). A support layer (24) on each electrode layer is also formed. Each support layer (24) comprises an aperture (25) at least partially aligned with the at least one ion channel (28). The ion filter is then separated. The risk of contaminants entering the at least one ion channel (28) when separating the ion filters is reduced by surrounding the at least one ion channel (28) with the isolation channel (30).

    ION MOBILITY FILTER
    95.
    发明申请
    ION MOBILITY FILTER 审中-公开

    公开(公告)号：WO2019048886A1

    公开(公告)日：2019-03-14

    申请号：PCT/GB2018/052562

    申请日：2018-09-10

    申请人： OWLSTONE MEDICAL LIMITED ,  OWLSTONE INC.

    发明人： MELHIRST, Daniel ,  PEARSON, Jon ,  ALLSWORTH, Max

    IPC分类号： G01N27/62 ,  H01J49/06

    摘要： An ion filter (120) for filtering ions in a gas sample. The ion filter (120) has a first ion channel (132) for filtering ions from a target chemical in the gas sample. The ion filter (120) has a second ion channel (134) for filtering ions from the target chemical in the gas sample. The second ion channel (134) is separated from the first ion channel (132). A temperature control region (136) is in thermal contact with the first and second ion channels for controlling a difference in temperature between the first and second ion channels (132), (134).A method of filtering ions from a target chemical in a gas sample is also provided.

    四重極型質量分析装置
    99.
    发明申请
    四重極型質量分析装置 审中-公开

    公开(公告)号：WO2019003365A1

    公开(公告)日：2019-01-03

    申请号：PCT/JP2017/023841

    申请日：2017-06-29

    申请人： 株式会社島津製作所

    发明人： 下村　学

    IPC分类号： H01J49/06 ,  G01N27/62 ,  H01J49/42

    摘要： ＣＤ電圧調整部（９６）により検出部（６）のコンバージョンダイノード（６１）に印加するＣＤ電圧を少しずつ変化させながら、分析制御部（９４）の制御の下で標準試料の測定を繰り返す。そして、実測のマススペクトルが得られる毎に、スペクトルパターン判定部（９３）は、実測マススペクトルのパターンが化合物データベース（９２）中の該標準試料の標準マススペクトルのパターンに一致しているか否か判定し、一致しているとみなせた時点のＣＤ電圧をその設定値に定める。イオンレンズ（３）への印加電圧を変えてマススペクトルのパターンを調整した場合、レンズ電極の汚れ等により感度等の性能が不安定になりがちであるが、検出部（６）はそうした汚れの影響を受けにくいので性能の不安定さを避けることができる。