公开(公告)号：WO1993005774A1

公开(公告)日：1993-04-01

申请号：PCT/US1992007949

申请日：1992-09-22

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： WISCONSIN ALUMNI RESEARCH FOUNDATION ,  DEUTSCH, Harold, F.

IPC: A61K31/20

CPC classification number: C07K14/4715 ,  A61K38/00

Abstract: Compositions are provided wherein a complex of an anthracycline antibiotic with a polyunsaturated fatty acid (with or without alpha -fetoprotein) is dissolved in a lipid emulsion. Dissolved uncomplexed alpha -fetoprotein can also be present. The compositions are useful in a method for the intravascular treatment of neoplastic tissue, especially alpha -fetoprotein producing hepatoma cells in humans, at high doses of the complex for relatively short periods of time.

Abstract translation: 提供了组合物，其中将蒽环类抗生素与多不饱和脂肪酸（有或没有α-甲胎蛋白）的复合物溶解在脂质乳剂中。 溶解的未复合的α-甲胎蛋白也可以存在。 组合物可用于血管内治疗肿瘤组织，特别是在人类中产生甲胎蛋白的肝细胞癌细胞，在相当短的时间段内在高剂量的复合物中。

公开(公告)号：WO1992009294A1

公开(公告)日：1992-06-11

申请号：PCT/US1991008046

申请日：1991-10-31

Applicant: BARNEA, Eytan, R.

IPC: A61K35/48

CPC classification number: C07K14/4715 ,  A61K38/00 ,  C07K16/18

Abstract: The present invention relates to substantially purified agents normally expressed during mammalian pregnancy that may be used to control the proliferation of cells, and, in particular, provides for proliferative agents as well as antiproliferative agents. The antiproliferative agents may be used to limit undesirable proliferation of cells, for example, in the treatment of cancer. The proliferative agents may be utilized to increase cell proliferation and may be used, for example, in the treatment of infertility.

Abstract translation: 本发明涉及通常在哺乳动物怀孕期间表达的可被用于控制细胞增殖的基本上纯化的试剂，特别是提供增殖剂以及抗增殖剂。 抗增生剂可用于限制细胞的不期望的增殖，例如用于治疗癌症。 增殖剂可用于增加细胞增殖，并且可以用于例如不孕症的治疗。

公开(公告)号：WO1991010443A1

公开(公告)日：1991-07-25

申请号：PCT/US1991000194

申请日：1991-01-09

Applicant: IDAHO RESEARCH FOUNDATION, INC.

Inventor： IDAHO RESEARCH FOUNDATION, INC. ,  SASSER, R., Garth

IPC: A61K37/02

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K14/4715 ,  Y10S514/885 ,  Y10S530/85

Abstract: Methods and compositions are provided for maintaining pregnancy and preventing rejection of transplanted tissue. A polypeptide characterized as capable of isolation from conceptus tissue and capable of inhibiting mitogen induced lymphocyte blastogenesis is employed which is introduced into the uterus or systemically.

Abstract translation: 提供了用于维持怀孕和防止移植组织排斥的方法和组合物。 特征在于能够从概念组织分离并能够抑制丝裂原诱导的淋巴细胞胚发生的多肽被使用，其被引入子宫或全身。

公开(公告)号：WO1990013655A1

公开(公告)日：1990-11-15

申请号：PCT/JP1990000557

申请日：1990-04-27

Applicant: SNOW BRAND MILK PRODUCTS CO., LTD. ,  MORINAGA, Tomonori ,  YASUDA, Naotaka ,  HIGASHIO, Kanji ,  TAMAOKI, Taiki

Inventor： SNOW BRAND MILK PRODUCTS CO., LTD.

IPC: C12N15/85

CPC classification number: C12N15/85 ,  C07K14/4715 ,  C12N2830/008

Abstract: A DNA which codes for a protein capable of combining specifically with an enhancer of an α-fetoprotein gene to thereby promote transcription of the gene. This DNA is useful for a system of manifestation of a large quantity of a physiologically active protein in an animal cell when it is applied to a recombinant DNA.

公开(公告)号：WO1987002368A1

公开(公告)日：1987-04-23

申请号：PCT/FR1986000353

申请日：1986-10-14

Applicant: GRABAR, Ludmilla, (héritière de GRABAR, Pierre ... ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ... ,  CHATEAUREYNAUD-DUPRAT, Pierrette, Marie ,  GIROUD, Jean-Paul

Inventor： GRABAR, Ludmilla, (héritière de GRABAR, Pierre ... ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ... ,  GRABAR, Pierre (décédé)

IPC: C07K15/00

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K14/4715 ,  G01N33/689

Abstract: New protein characterized particularly in that it is present in the serum of pregnant females and normally absent in males; in that it is present in the serum of individuals who develop an inflammatory reaction; in that it migrates in electrophoresis with alpha2-macroglobulines; in that it has a molecular mass of 800.000 9E 50.000 approximately measured by filtration on polyacrylamide gel; and in that its administration in vivo prolongs significantly the survival of allografts; antibodies directed against said protein; preparation thereof and application thereof particularly as medecine.

公开(公告)号：WO1985001958A1

公开(公告)日：1985-05-09

申请号：PCT/US1984001766

申请日：1984-10-31

Applicant: REDDY, Vemuri, B. ,  HSIUNG, Nancy ,  BECK, Anton, K. ,  BERNSTINE, Edward, George

IPC: C12P21/00

CPC classification number: C12N15/85 ,  A61K38/00 ,  C07K14/4715 ,  C07K14/59 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

Abstract: A biologically active secreted protein composed of a plurality of subunits is prepared by a recombinant methodology. Each subunit is synthesized by a cell having an autonomously replicating expression vector I.E. a plasmid or virus containing heterologous DNA encoding for the subunit. The preferred host is a eukaryotic cell. The secreted protein is a hormone such as hCG, luteinizing hormone (LH), follicle stimulating hormone (FSH) or thyroid stimulating hormone (TSH).

Abstract translation: 通过重组方法制备由多个亚基组成的生物活性分泌蛋白。 每个亚基由具有自主复制的表达载体I.E的细胞合成。 含有编码亚基的异源DNA的质粒或病毒。 优选的宿主是真核细胞。 分泌的蛋白质是激素如hCG，黄体生成激素（LH），促卵泡激素（FSH）或促甲状腺激素（TSH）。