公开(公告)号：WO2021183628A8

公开(公告)日：2021-09-16

申请号：PCT/US2021/021679

申请日：2021-03-10

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： BERGESON, Susan ,  SYAPIN, Peter ,  REID, Ted W. ,  SHASHTRI, Mayank ,  TRAN, Phat

IPC: A61K31/65 ,  C07C237/26 ,  A61P25/32 ,  A61P31/00 ,  C07C237/52 ,  C07C2603/46 ,  G01N33/5088

Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising a modified tetracycline molecule, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, and tautomers thereof comprise: a Deamino Diacetyl Minocycline, Methyl Ether Minocycline, Ethyl Ether Minocycline, Propyl Ether Minocycline, Butyl Ether Minocycline, Butyl Ether Monoacetyl Minocycline, Butyl Ether Diacetyl Minocycline, Buty Ether Triacetyl Minocycline, or Butyl Ether Tetra Acetyl Minocycline.

公开(公告)号：WO2021183183A1

公开(公告)日：2021-09-16

申请号：PCT/US2020/053367

申请日：2020-09-30

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： WEINDORF, David, C. ,  CHAKRABORTY, Somsubhra

IPC: G01N23/223 ,  G01N21/359 ,  G01N33/24

Abstract: An apparatus or method determines a content of the one or more elements of a solid matrix by scanning the solid matrix using a PXRF spectrometer and a color sensor, receiving a PXRF spectra from the PXRF spectrometer and a numerical color data from the color sensor, extracting a value for each of the one or more elements the PXRF spectra, determining the content of the one or more elements of the solid matrix using one or more processors and a predictive model that relates the value of each of the one or more elements and the numerical color data to the content of the one or more elements of the solid matrix, and providing the content of the one or more elements of the solid matrix to one or more input/output interfaces.

公开(公告)号：WO2021168465A1

公开(公告)日：2021-08-26

申请号：PCT/US2021/019257

申请日：2021-02-23

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： KIM, Sangsik ,  MIA, Md, Borhan

IPC: G02B6/122 ,  G02B6/12

Abstract: An optical waveguide includes a first waveguide core, a second waveguide core, a first subwavelength multilayer cladding, a second subwavelength multilayer cladding and a third subwavelength multilayer cladding. The first waveguide core and the second waveguide core have a width (w) and a height ( h ). The first waveguide core is disposed between the first subwavelength multilayer cladding and the second subwavelength multilayer cladding. The second waveguide core is disposed between the second subwavelength multilayer cladding and the third subwavelength multilayer cladding. Each subwavelength multilayer cladding has a number (TV) of alternating subwavelength ridges having a periodicy (A) and a filling fraction (p). A total coupling coefficient (|/c|) of the first waveguide core and the second waveguide core is from 10 to 0.

公开(公告)号：WO2020117960A1

公开(公告)日：2020-06-11

申请号：PCT/US2019/064513

申请日：2019-12-04

Applicant: EVOLUTION SPINE

Inventor： PANCHAL, Ripul

IPC: A61B17/76 ,  A61B17/70 ,  A61F2/44 ,  A61B17/86 ,  A61F2/30 ,  A61B17/68

Abstract: A vertebral plate and method is disclosed. The vertebral plate comprises a frame having a triangular shape. A screw hole is present on each comer of the frame. Each screw hole is designed to receive a screw. Optionally, a viewing window is disposed within an interior of the frame.

公开(公告)号：WO2020047185A9

公开(公告)日：2020-03-05

申请号：PCT/US2019/048702

申请日：2019-08-29

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： KARAMYAN, Vardan, T. ,  TRIPPIER, Paul ,  OSTROV, David, A. ,  ABBRUSCATO, Tom ,  JAYARAMAN, Srinidhi

IPC: C07K1/22 ,  C07K14/47 ,  C07K17/14 ,  C07K19/00 ,  C12N9/16 ,  C12P21/02

Abstract: The present invention includes a composition and method of allosterically potentiating the activity of neurolysin comprising contacting the neurolysin with an amount of a histidine-containing dipeptide that is an allosteric that increases the activity of neurolysin.

公开(公告)号：WO2020046279A1

公开(公告)日：2020-03-05

申请号：PCT/US2018/048299

申请日：2018-08-28

Applicant: GOMEZ, Eduardo Roberto

Inventor： GOMEZ, Eduardo Roberto

IPC: A63D15/10 ,  A63D15/00

Abstract: The invention presents a hand held guide for cue shaft with an adjustable handle for playing billiard games. The guide comprises an elongated "V"-shaped guide containing said adjustable handle at least one axis that allow the pieces forming the axis to articulate up to 180 degrees. In addition, the handle contains at least one adjustable grip and the elongated "V"-shaped guide contains at least one concave groove to place the index finger or the middle finger when the person using the guide performs a closed bridge to wrap the guide.

公开(公告)号：WO2020006033A1

公开(公告)日：2020-01-02

申请号：PCT/US2019/039162

申请日：2019-06-26

Applicant: SIGNPATH PHARMA, INC.

Inventor： MCCHESNEY, James ,  BOUCHARD, Annie ,  KAPPUSAMY, Saravanan ,  ANGUSTINE, John, Kallikat ,  LEVY, Daniel, Emil

IPC: A61K31/225 ,  A61K31/66 ,  A61K31/683 ,  C07F9/02 ,  C07F9/06 ,  C07F9/09

Abstract: The present invention includes compound having the following structural formula: (I).

公开(公告)号：WO2019136462A1

公开(公告)日：2019-07-11

申请号：PCT/US2019/012740

申请日：2019-01-08

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： KREMEN, Vaclav ,  BERRY, Brent, M. ,  BRINKMANN, Benjamin, H. ,  STEAD, Squire, Matt

IPC: A61B5/048

Abstract: A behavioral state of a brain is classified by automatically selecting one or more sensors based on the signals received from each sensor and one or more selection criteria using one or more processors, calculating at least one measured value from the signal(s) of the selected sensor(s), classifying the behavioral state as: (a) an awake state whenever the measured value(s) for the selected sensor(s) is lower than a first threshold value, (b) a sleep state (N2) whenever the measured value(s) for the selected sensor(s) is equal to or greater than the first threshold value and the measured value(s) is not greater than a second threshold value, or (c) a slow wave sleep state (N3) whenever the measured value(s) from the selected sensor(s) is greater than the first threshold value and the measured value(s) is greater than the second threshold value, and providing a notification of the classified behavioral state.

公开(公告)号：WO2019136024A1

公开(公告)日：2019-07-11

申请号：PCT/US2018/068184

申请日：2018-12-31

Applicant: 3D GLASS SOLUTIONS, INC.

Inventor： FLEMMING, Jeb H. ,  McWETHY, Kyle

IPC: H03H1/00 ,  H03H7/38 ,  H05K1/03

Abstract: The present invention includes a method of making a RF impedance matching device in a photo definable glass ceramic substrate. A ground plane may be used to adjacent to or below the RF Transmission Line in order to prevent parasitic electronic signals, RF signals, differential voltage build up and floating grounds from disrupting and degrading the performance of isolated electronic devices by the fabrication of electrical isolation and ground plane structures on a photo-definable glass substrate.

公开(公告)号：WO2019084024A8

公开(公告)日：2019-05-02

申请号：PCT/US2018/057131

申请日：2018-10-23

Applicant: OKLAHOMA MEDICAL RESEARCH FOUNDATION ,  UNIVERSITY OF OKLAHOMA HEALTH SCIENCE CENTER

Inventor： KONDO, Yuji ,  FU, Jianxin ,  WANG, Hua ,  WIERENGA, Klaas ,  GAFFNEY, Patrick M. ,  XIA, Lijun

IPC: G06T15/00

Abstract: The present invention includes a method of treating a bone disease caused by a intracellular protein trafficking defect comprising: identifying a subject having the bone disease caused by the intracellular protein trafficking defect in a membrane bound transcription factor peptidase, site 1 (MBTPS1) gene; and providing the subject with an effective amount of a composition that bypasses or corrects a defect in MBTPS1 gene expression, gene splicing, or corrects protein trafficking defects in the endoplasmic reticulum and to the lysosome.