公开(公告)号：WO2022180199A1

公开(公告)日：2022-09-01

申请号：PCT/EP2022/054758

申请日：2022-02-25

申请人： EXINOV

发明人： LALLEMAND, Frédéric ,  SCHMITT, Mathieu

IPC分类号： A61K31/201 ,  A61P17/00 ,  A61K9/00 ,  A61K31/01 ,  A61K31/202 ,  A61K31/23 ,  A61K31/231 ,  A61K31/232 ,  A61K31/683 ,  A61K31/77 ,  A61K31/775 ,  A61K36/00 ,  A61K31/20 ,  A61K31/4164 ,  A61K31/498 ,  A61K31/7048 ,  A61K47/14 ,  A61K47/24 ,  A61K9/107

摘要： The present invention relates to an emulsion comprising (i) at least one oil, (ii) at least one phospholipid and (iii) at least one polymeric surfactant. Typically, the oil is a mixture of triglycerides and fatty acids. The present invention also relates to the emulsion according to the invention for use in the treatment and/or prevention of a skin disease, in particular rosacea. The emulsion according to the invention is therapeutically active as such, even when it comprises only excipients and no therapeutic agent against a skin disease. The emulsion according to the invention may also be used as a topical vehicle for a therapeutic agent against a skin disease. The present invention also relates to a method for the treatment and/or prevention of a skin disease in a subject in need thereof, the method comprising a step of administration of a therapeutically effective amount of an emulsion according to the invention.

公开(公告)号：WO2021199003A1

公开(公告)日：2021-10-07

申请号：PCT/IB2021/052786

申请日：2021-04-02

申请人： VASCULAR BIOGENICS LTD.

发明人： MINEI, Tami Rachmilewitz ,  MENDEL, Itzhak ,  ISHAI, Eti ,  SHER, Naamit ,  FEIGE, Erez ,  BREITBART, Eyal ,  YACOV, Niva

IPC分类号： A61K31/66 ,  A61K31/683 ,  C07C43/10 ,  C07C59/125

摘要： The present invention is directed to methods of treating or preventing inflammation caused by a coronavirus infection with oxidized lipid compounds (e.g., VB-201). The present invention also directed to methods of treating or preventing an infectious disease or symptom caused by a coronavirus infection with oxidized lipid compounds. The present invention is also directed to kits comprising an oxidized lipid and instructions for administering the oxidized lipid to a subject having or suspected of having inflammation or an infectious disease or symptom caused by a coronavirus infection.

公开(公告)号：WO2021170741A1

公开(公告)日：2021-09-02

申请号：PCT/EP2021/054727

申请日：2021-02-25

申请人： JANSSEN SCIENCES IRELAND UNLIMITED COMPANY

发明人： LENZ, Oliver ,  TALLOEN, Willem, Jan-Paul, Edmond ,  VANDENBOSSCHE, Joris, Jozef ,  YOGARATNAM, Jeysen, Zivan

IPC分类号： A61K31/401 ,  A61K31/522 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  A61P31/20

摘要： The present disclosure is directed to methods of using a capsid assembly inhibitor for the treatment of hepatitis B virus infection.

公开(公告)号：WO2021034804A1

公开(公告)日：2021-02-25

申请号：PCT/US2020/046758

申请日：2020-08-18

申请人： GILEAD SCIENCES, INC.

发明人： BANE, Jessica M. ,  NEJATI, Elham ,  STEFANIDIS, Dimitrios

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/675 ,  A61K31/683

摘要： Long-acting formulations comprising isopropyl ((S)-((((R)-l-(6-amino-9H-purin-9- yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate, or a pharmaceutically acceptable salt thereof, and a biodegradable polymer, e.g. poly(lactic-co-glycolic acid) (PLGA), are described, as are methods of making the long acting formulations and uses thereof.

公开(公告)号：WO2020176488A8

公开(公告)日：2020-09-03

申请号：PCT/US2020/019681

申请日：2020-02-25

申请人： EISOHLY, Mahmoud, A. ,  GUL, Waseem

发明人： EISOHLY, Mahmoud, A. ,  GUL, Waseem

IPC分类号： A61K31/357 ,  A61K31/4433 ,  A61K31/683 ,  A61K31/255 ,  A61K31/4453 ,  A61K31/496 ,  A61K31/5377 ,  A50

摘要： New compositions are provided containing artemisinin dimers with high activity as anti-protozoal agents, including ant-malarial and anti-leishmanial properties, and methods for the treatment of protozolal infections, including malaria or leishmaniasis.

公开(公告)号：WO2020109328A1

公开(公告)日：2020-06-04

申请号：PCT/EP2019/082624

申请日：2019-11-26

申请人： DEBIOPHARM INTERNATIONAL S.A.

发明人： VUAGNIAUX, Grégoire ,  WIEDEMANN, Norbert

IPC分类号： A61K31/407 ,  A61P31/18 ,  A61K31/513 ,  A61K31/683 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28

摘要： The present invention provides combination therapies for the treatment of HIV. The combination therapies of the present invention are aimed to reverse HIV latency and ultimately cure the disease. The combination therapies of the invention involve the use of an IAP inhibitor and the use of an immune checkpoint inhibitor.

公开(公告)号：WO2020064980A1

公开(公告)日：2020-04-02

申请号：PCT/EP2019/076130

申请日：2019-09-27

申请人： JANSSEN SCIENCES IRELAND UNLIMITED COMPANY

发明人： PAVLAKI, Aikaterini ,  ZAVITSANOU, Asimina

IPC分类号： A61K31/5377 ,  A61K31/635 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7068 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  A61P31/18

摘要： The disclosure is directed to methods of treating humans diagnosed with an HIV infection and who are also diagnosed with a neuropsychiatric and/or neurocognitive complication of an HIV infection or who are also predisposed to a neuropsychiatric and/or a neurocognitive complication of an HIV infection.

公开(公告)号：WO2019183004A1

公开(公告)日：2019-09-26

申请号：PCT/US2019/022824

申请日：2019-03-18

申请人： VIKING THERAPEUTICS, INC.

发明人： LIAN, Brian ,  MASAMUNE, Hiroko ,  BARKER, Geoffrey

IPC分类号： C07F9/6571 ,  A61K31/683

摘要： Disclosed herein are methods of crystallizing the compound of Formula I, as well as crystalline forms thereof. Crystalline forms of Formula I disclosed include the TBME solvate crystalline form, toluene solvate crystalline form, ethanol solvate crystalline form, THF solvate crystalline form, EtOAc solvate crystalline form, acetone solvate crystalline form and crystalline Form C.

公开(公告)号：WO2018104512A1

公开(公告)日：2018-06-14

申请号：PCT/EP2017/081998

申请日：2017-12-08

申请人： N.V. NUTRICIA

发明人： SCHIPPER, Anniek Lidewij ,  VAN DER BEEK, Eline Marleen ,  ACTON, Dennis Stanley ,  BARTKE, Nana ,  SCHOEN, Stefanie

IPC分类号： A23D9/013 ,  A61K31/201 ,  A61K31/202 ,  A61K31/683 ,  A23L33/00 ,  A23L33/12 ,  A61P25/32 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P25/16 ,  A61P25/30

摘要： An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.

公开(公告)号：WO2014183550A1

公开(公告)日：2014-11-20

申请号：PCT/CN2014/076313

申请日：2014-04-28

申请人： 张雅茹 ,  王西岭

发明人： 张雅茹 ,  王西岭

IPC分类号： C07J9/00 ,  C12P33/00 ,  A61K31/683 ,  A23L1/29 ,  A61P3/06 ,  A23C9/152 ,  A23C11/10 ,  A23D9/007 ,  A23L2/52 ,  A23L1/164

CPC分类号： C07J9/00 ,  A23C11/103 ,  A23D9/013 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  C07J51/00 ,  C12P7/6481 ,  C12P33/00

摘要： 本发明提供了富含多不饱脂肪酰基的磷脂酰甾醇和/或磷脂酰甾烷醇及其制备方法，主要解决现有植物甾醇可溶性差生物利用度低以及其酯化物制备方法中使用有毒试剂、反应条件苛刻以及无法工业化生产等技术问题。结构式如式（I）所示，式中：Sn-1、Sn-2和Sn-3分别指磷脂中甘油酯基团的1位、2位和3位；R 1 和R 2 为下述基团中的一种：-C 19 H 29 、-C 19 H 31 、-C 21 H 31 或-C 21 H 33 ，X为甾醇或甾烷醇中的一种。本发明能够有效降低血浆中胆固醇和甘油三酯含量的功效价值，并提供了应用领域和范围。