公开(公告)号：WO1993006822A1

公开(公告)日：1993-04-15

申请号：PCT/US1992008549

申请日：1992-10-08

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  MENDES, Robert, W. ,  PATHAK, Nitin ,  CLEMENTE, Emmett

IPC分类号： A61K31/09

CPC分类号： A61K9/0095 ,  A61K31/505

摘要： This invention is directed to an aqueous pharmaceutical composition with 1.25 mg to about 10 mg trimethoprim per mL (wt/vol) of solution and a compound of suitable acid strength to permit the dissolving of trimethoprim at the appropriate concentration, with the composition having a pH of less than 6.0. This composition is particularly useful for pediatric oral use.

摘要翻译： 本发明涉及含有1.25mg至约10mg甲氧苄啶/ mL（wt / vol）溶液的水性药物组合物和具有适合酸强度的化合物，以使甲氧苄啶溶解至适当浓度，组合物具有pH 小于6.0。 该组合物特别适用于儿科口服使用。