公开(公告)号：WO2017189947A1

公开(公告)日：2017-11-02

申请号：PCT/US2017/030026

申请日：2017-04-28

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： GUMUDAVELLI, Sridhar ,  KAKULLAMARRI, Praneeth Rao ,  VIDIYALA, Sudhakar ,  REDDY, Madhava

IPC分类号： A61K31/485 ,  A61K9/16 ,  A61K9/48 ,  A61K47/12 ,  A61K47/44

摘要： This invention relates to pharmaceutical dosage forms for delivery of drugs susceptible to abuse, such as, for example, oxycodone and/or oxymorphone.

摘要翻译： 本发明涉及递送易滥用药物的药物剂型，例如羟考酮和/或羟吗啡酮。

公开(公告)号：WO1996031204A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004003

申请日：1996-03-25

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  CLEMENTE, Emmett ,  MENDES, Robert, W. ,  ANAEBONAM, Aloysius, O. ,  AHMED, Mumtaz

IPC分类号： A61K31/35

CPC分类号： A61K31/352

摘要： A process and pharmaceutical composition for treatment of hemangioma in humans is disclosed. The pharmaceutical composition comprises a chromone compound of formula (I), or a pharmacologically acceptable salt, ester or amide thereof, dissolved or dispersed in a pharmacologically acceptable carrier. In accordance with the process, a therapeutically effective amount of the composition is topically administered to a hemangioma of a human patient.

摘要翻译： 公开了一种用于治疗人类血管瘤的方法和药物组合物。 药物组合物包含溶解或分散在药理学上可接受的载体中的式（I）的色酮化合物或其药学上可接受的盐，酯或酰胺。 根据该方法，将治疗有效量的组合物局部施用于人类患者的血管瘤。

公开(公告)号：WO1995035096A1

公开(公告)日：1995-12-28

申请号：PCT/US1995007908

申请日：1995-06-21

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  TABIBI, S., Esmail ,  MENDES, Robert, W. ,  PATHAK, Nitin, P.

IPC分类号： A61K09/14

CPC分类号： A61K9/5123 ,  A61K9/0095

摘要： A controlled release aqueous emulsion is disclosed, as are its method of manufacture and use as a vehicle for delivering medicaments in liquid form. A contemplated emulsion comprises a wax containing oil-in-water emulsion having an average oil particle size of about 100 nm to about 250 nm, a pH value of about 4.5 to about 8.0 and a viscosity at 20-25 C of 1 to about 1000 cps. The oil and water phases are emulsified by an emulsifying agent that provides freedom from phase separation at a pH value of about 4.5 to about 8, while also providing phase separation at a pH value below about 2.0.

摘要翻译： 公开了一种控释水乳液，以及其作为用于输送液体形式的药物的载体的制造和使用方法。 预期的乳液包括具有平均油粒度为约100nm至约250nm，pH值为约4.5至约8.0和在20-25℃下的粘度为1至约1000的含水包油乳液 CPS。 油相和水相通过乳化剂乳化，其在约4.5至约8的pH值下提供免于相分离的同时，还提供pH值低于约2.0的相分离。

公开(公告)号：WO2018112119A1

公开(公告)日：2018-06-21

申请号：PCT/US2017/066251

申请日：2017-12-14

申请人： ASCENT PHARMACEUTICALS, INC

发明人： GUMUDAVELLI, Sridhar ,  MADHAVA, Reddy ,  SUDHAKAR, Vidiyala

IPC分类号： A61K9/00 ,  A61K31/352 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/44

CPC分类号： A61K31/352 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/1075 ,  A61K9/50 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44 ,  A61P1/08

摘要： The present invention discloses a means to improve stability, dissolution, and in vivo bioavailability of non-aqueous oral formulations containing natural or synthetic cannabinoid derivatives. In particular, this invention provides a non-aqueous cannabinoid formulation containing zero amount of water with one or more organic solvents, surfactants, co-surfactants, semi-polar solvents and mono-di glycerides. Upon administration, these formulations produce nano-sized cannabinoid liquid globules.

公开(公告)号：WO1996031205A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004004

申请日：1996-03-25

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  CLEMENTE, Emmet ,  MENDES, Robert, W. ,  ANAEBONAM, Aloysius, O. ,  AHMED, Mumtaz

IPC分类号： A61K31/35

CPC分类号： A61K9/0014 ,  A61K31/352 ,  A61K47/14

摘要： A process and pharmaceutical composition for treatment of uremic pruritus in humans is disclosed. The pharmaceutical composition comprises of a chromone compound of formula (I), or a pharmacologically acceptable salt, ester or amide thereof dissolved or dispersed in a pharmacologically acceptable carrier. In accordance with the process, a therapeutically effective amount of the composition is topically administered to a pruritic lesion of a human patient.

摘要翻译： 公开了用于治疗人类尿毒症瘙痒症的方法和药物组合物。 药物组合物包含溶解或分散在药理学上可接受的载体中的式（I）的色酮化合物或其药理学上可接受的盐，酯或酰胺。 根据该方法，将治疗有效量的组合物局部施用于人类患者的瘙痒性损伤。

公开(公告)号：WO1996031193A1

公开(公告)日：1996-10-10

申请号：PCT/US1996003966

申请日：1996-03-25

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  CLEMENTE, Emmett ,  MENDES, Robert, W. ,  ANAEBONAM, Aloysius, O. ,  AHMED, Mumtaz

IPC分类号： A61K07/48

CPC分类号： A61K31/352 ,  A61K31/353 ,  Y10S514/829 ,  Y10S514/83 ,  Y10S514/937

摘要： A process and pharmaceutical composition for the prevention and treatment of cutaneous Type I hypersensitivity reactions in humans is disclosed. The pharmaceutical composition comprises a chromone compound of formula (I), or a pharmacologically acceptable salt, ester or amide thereof, dissolved or dispersed in a pharmacologically acceptable carrier. In accordance with the process, a preventively or therapeutically effective amount of the composition is topically administered to a human patient, as required; i.e. for prevention the composition is administered to the area of skin susceptible to exposure to antigen and for treatment the composition is administered to the reaction site.

摘要翻译： 公开了用于预防和治疗人类皮肤I型超敏反应的方法和药物组合物。 药物组合物包含溶解或分散在药理学上可接受的载体中的式（I）的色酮化合物或其药学上可接受的盐，酯或酰胺。 根据该方法，根据需要将预防性或治疗有效量的组合物局部施用于人类患者; 即防止将组合物施用于易暴露于抗原的皮肤区域，并且为了处理，将组合物施用于反应部位。

公开(公告)号：WO2017184584A1

公开(公告)日：2017-10-26

申请号：PCT/US2017/028102

申请日：2017-04-18

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： GUMUDAVELLI, Sridhar ,  VIDIYALA, Sudhakar ,  REDDY, Madhava

IPC分类号： A61J1/03 ,  B65D75/32

CPC分类号： A61J1/035 ,  A61K9/48 ,  A61K31/22 ,  A61K31/352 ,  A61K47/02 ,  B01J20/103 ,  B01J2220/66 ,  B65D75/328 ,  B65D75/368 ,  B65D81/264 ,  B65D81/268

摘要： The invention describes a blister packaging system, and method of making the system, capable of establishing and maintaining arid and anaerobic conditions for packaging pharmaceutical products that are sensitive to oxygen and/or moisture. The blister packaging system encompasses, for example, a scaffold of several interconnected cavities intended for product and one or more reservoirs comprising an oxygen scavenger and/or a desiccant. Furthermore, the concentration of the components is maintained at a level that prevents establishment of equilibrium conditions.

摘要翻译： 本发明描述了一种泡罩包装系统和制造该系统的方法，该系统能够建立和保持干燥和厌氧条件以包装对氧气和/或湿气敏感的药物产品。 泡罩包装系统包括例如用于产品的几个互连空腔的支架和包含除氧剂和/或干燥剂的一个或多个储存器。 此外，组分的浓度保持在阻止建立平衡条件的水平。

公开(公告)号：WO1996031203A1

公开(公告)日：1996-10-10

申请号：PCT/US1996003962

申请日：1996-03-25

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  CLEMENTE, Emmett ,  MENDES, Robert, W. ,  ANAEBONAM, Aloysius, O. ,  AHMED, Mumtaz

IPC分类号： A61K31/35

CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K47/14

摘要： A process and pharmaceutical composition for prevention and treatment of cutaneous delayed (Type IV A) hypersensitivity reactions in humans is disclosed. The pharmaceutical composition comprises a chromone compound of formula (I), or a pharmacologically acceptable salt, ester or amide thereof, dissolved or dispersed in a pharmacologically acceptable carrier. In accordance with the process, a preventively or therapeutically effective amount of the composition is topically administered to the site of a human patient regarding such treatment, i.e. the area susceptible to exposure to antigen or the site of a cutaneous Type IV A reaction.

摘要翻译： 公开了用于预防和治疗人类皮肤延迟（IVA型）超敏反应的方法和药物组合物。 药物组合物包含溶解或分散在药理学上可接受的载体中的式（I）的色酮化合物或其药学上可接受的盐，酯或酰胺。 根据该方法，将预防或治疗有效量的组合物局部施用于人类患者关于这种治疗的部位，即易于暴露于抗原或皮肤IVA型反应部位的区域。

公开(公告)号：WO1996020697A1

公开(公告)日：1996-07-11

申请号：PCT/US1995012690

申请日：1995-10-03

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  ANAEBONAM, Aloysius, O. ,  FAWZY, Abdel, A. ,  CLEMENTE, Emmett

IPC分类号： A61K09/16

CPC分类号： A61K9/0095 ,  A61K31/445

摘要： The present invention contemplates a dry, granular terfenadine composition. That composition comprises (i) particulate terfenadine and (ii) a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer having an HLB number of 24 that is a wetting agent for the terfenadine that are dry-blendedly dispersed onto (iii) spray-dried sorbitol particles that are loosely packed, randomly oriented filamentary crystals having pores that entrap the particulate terfenadine and wetting agent upon the dry-blended dispersal. The weight ratio of particulate terfenadine to the block copolymer is about 1:1 to about 1:5:1, and the weight ratio of terfenadine to the spray-dried sorbitol is about 1:4 to about 1:10. The composition is free-flowing and is substantially free from the taste of solubilized terfenadine when placed on the human tongue in dry form or when dispersed in water and tasted within about five minutes of said dispersal. A preferred composition further includes dry-blendedly admixed polyvinylpyrrolidone present in an amont of about 0.5 to about 5 weight percent of the total composition. Flavorants can also be present.

摘要翻译： 本发明考虑了干燥的颗粒特非那定组合物。 该组合物包含（i）颗粒特非那定和（ii）HLB数为24的聚环氧乙烷 - 聚环氧丙烷 - 聚环氧乙烷嵌段共聚物，其为特非拉定的润湿剂，其干混合分散在（iii）喷雾干燥 松散填充的山梨糖醇颗粒，随机取向的丝状晶体，其具有将颗粒物特非那定和润湿剂截留在干混分散体上的孔。 颗粒特非那定与嵌段共聚物的重量比为约1:1至约1:5:1，特非那定与喷雾干燥山梨醇的重量比为约1:4至约1:10。 组合物是自由流动的，并且当以干燥形式放置在人舌上或当分散在水中并在所述分散的约5分钟内品尝时，基本上不溶解的特非那定的味道。 优选的组合物还包括以总组合物的约0.5至约5重量％存在的干混混合的聚乙烯吡咯烷酮。 调味剂也可以存在。

公开(公告)号：WO1994007467A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009139

申请日：1993-09-30

申请人： ASCENT PHARMACEUTICALS, INC.

发明人： ASCENT PHARMACEUTICALS, INC. ,  MENDES, Robert, W. ,  JAVROONGRIT, Yuppadee ,  ANAEBONAM, Aloysius ,  CLEMENTE, Emmett

IPC分类号： A61K09/14

CPC分类号： A61K9/0056 ,  A61K31/78

摘要： This invention is directed to pharmaceutical compositions of calcium polycarbophil (CPC) sprinkles. The CPC sprinkles contain very fine calcium polycarbophil powder, with smooth particles, and are processed with one or more excipients to produce a flowable, dispersible composition. For pediatric dosing, the CPC sprinkles are premixed with food and when placed in the mouth, its smooth and creamy consistency makes it easy to ingest without leaving a gritty mouthfeel.

摘要翻译： 本发明涉及聚羧酸钙（CPC）喷洒剂的药物组合物。 CPC喷洒含有非常细的钙聚卡波非粉末，具有光滑的颗粒，并用一种​​或多种赋形剂加工以产生可流动的可分散的组合物。 对于儿科剂量，CPC喷洒与食物预混合，当放在口中时，其光滑和奶油稠度使得容易摄取而不留下粗糙的口感。