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公开(公告)号：WO2019122165A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086260
申请日：2018-12-20
申请人： ASAMEDIC AS
IPC分类号： A61K31/616 , A61K47/02 , A61K9/00 , A61K9/08 , A61P9/10
CPC分类号： A61K31/616 , A61K9/0095 , A61K9/08 , A61K47/02
摘要： The present invention relates to a novel two-component system comprising acetylsalicylic acid (ASA) and which is particularly useful in providing an aqueous solution of ASA for immediate peroral administration.
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公开(公告)号：WO2019122068A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/086078
申请日：2018-12-20
发明人： WANG, Chen-Chao
IPC分类号： A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22 , A61K9/00 , A61K47/24 , A61K9/08 , A61K31/00 , A61K47/14
CPC分类号： A61K9/08 , A61K9/0095 , A61K31/438 , A61K31/454 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/24
摘要： An oral pharmaceutical composition comprising telmapitant, a non-aqueous solvent and one or more additional pharmaceutical acceptable excipients wherein the telmapitant is in solution in the composition. A method of treatment or prevention of emesis in animals comprising administering the oral pharmaceutical composition.
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公开(公告)号：WO2019102218A2
公开(公告)日：2019-05-31
申请号：PCT/GB2018/053402
申请日：2018-11-23
申请人： OPTIBIOTIX LIMITED
发明人： O'HARA, Stephen , KOLIDA, Sofia
CPC分类号： A61P1/00 , A23L33/135 , A23L33/21 , A23L33/24 , A23V2002/00 , A61K9/0095 , A61K31/702 , A61K35/747 , C12N1/20 , C12R1/25 , A61K2300/00 , A23V2200/3202 , A23V2200/3204 , A23V2250/284 , A23Y2220/67 , A23Y2220/73
摘要： The present invention relates to a Lactobacillus spp. selective prebiotic composition comprising one, or a mixture of two or more, of: xylooligosaccharides, cellobiose and/or gentiooligosaccharides. The present invention also relates to a synbiotic composition comprising a probiotic component comprising one or more strains of Lactobacillus rhamnosus and/or one or more strains of Lactobacillus plantarum and a prebiotic component comprising a growth medium which is specific for the growth of the probiotic component, wherein the prebiotic growth medium comprises one or more, or a mixture of two of more, components selected from: xylooligosaccharides, cellobiose and/or gentiooligosaccharides. The present invention also relates to methods of producing and selecting such compositions.
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公开(公告)号：WO2019040346A1
公开(公告)日：2019-02-28
申请号：PCT/US2018/047015
申请日：2018-08-20
CPC分类号： A61K9/146 , A61K9/0095 , A61K9/10 , A61K9/145 , A61K9/2004 , A61K9/48 , A61K47/10 , A61K47/38
摘要： The present invention relates to methods for producing a stable amorphous dispersion of a pharmaceutically active substance having poor water solubility by applying low frequency acoustic energy to a mixture comprising the active substance and at least one polymer and heating the mixture until a stable amorphous dispersion is formed. The methods of the invention are an effective means of converting a crystalline API to a substantially amorphous and stable form, i.e., wherein the crystallinity is less than about 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared to typical amorphization or literature methods.
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公开(公告)号：WO2018232884A1
公开(公告)日：2018-12-27
申请号：PCT/CN2017/096701
申请日：2017-08-10
申请人： 广州市金因源生物技术有限公司
CPC分类号： A61K9/0095 , A61K36/07 , A61K36/42
摘要： 一种同时具有降血压和降血糖作用的组合物及其制备方法。该组合物由裂蹄木层孔菌固体培养物、罗汉果和水制备而得，具有降血压和降血糖的双重功能，可用于制备防治降血压和降血糖的药物。制备方法工艺简单、成本低廉。
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公开(公告)号：WO2018167628A1
公开(公告)日：2018-09-20
申请号：PCT/IB2018/051597
申请日：2018-03-12
CPC分类号： A61K9/0095 , A61K9/10 , A61K31/5377 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/36
摘要： The present invention provides pharmaceutical composition of immunosuppressive agent in oral suspension dosage form. The oral suspension composition comprises of immunosuppressive agent with other pharmaceutical excipients such as vehicle, suspending agent, solvent or cosolvent, preservative, sweetener, antifoaming agent, wetting agent, buffering agent and flavouring agent. The present invention oral suspension having improved stability, palatability with high dose of active ingredient. The present invention provides oral suspension with flavor that has masked bitter taste of the drug and eliminates difficulty of administration. Further, the present invention also provides a convenient, easy process for preparation thereof.
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公开(公告)号：WO2018045170A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049618
申请日：2017-08-31
IPC分类号： A61K9/08 , A61K47/10 , A61K31/09 , A61K31/137 , A61K31/167 , A61K31/485 , A23L27/00
CPC分类号： A61K47/18 , A61K9/0095 , A61K9/08 , A61K31/09 , A61K31/137 , A61K31/167 , A61K31/485 , A61K47/10
摘要： A liquid medication in a bottle that comprises three to four pharmaceutical actives selected from the group consisting of guaifenesin, acetaminophen, dextromethorphan, phenylephrine, pharmaceutically acceptable salts thereof and combinations thereof, ethyl 3-(p-menthane-3-carboxamido)acetate and menthol. The liquid medication can provide a taste and sensory experience that appeals to consumers.
摘要翻译： 包含三至四种药用活性成分的瓶中的液体药剂，所述药用活性成分选自愈创甘油醚，对乙酰氨基酚，右美沙芬，去氧肾上腺素，其药学上可接受的盐及其组合，3-（对薄荷烷 -3-甲酰氨基）乙酸酯和薄荷醇。 液体药物可以提供吸引消费者的味道和感官体验。
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公开(公告)号：WO2018045122A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049522
申请日：2017-08-31
IPC分类号： A23L33/21 , A23L2/60 , A61K47/26 , A61K31/702 , C07H3/06 , A23L27/00 , A23L27/30 , A23L33/125
CPC分类号： A23L2/60 , A23L27/30 , A23L27/84 , A23L27/86 , A23L33/125 , A23L33/21 , A23V2002/00 , A23V2200/16 , A23V2250/28 , A61K9/0095 , A61K47/26 , C07H3/06
摘要： Tri- and tetra-saccharides are used in foods, beverages and other consumable products to mask or reduce the unpleasant taste of certain components also present in such products, such as the bitter taste of certain high intensity sweeteners. The organoleptic qualities of the products are thereby improved. In particular, melezitose, maltotriose and maltotetraose effectively reduce the bitterness of consumable products containing steviol glycosides such as rebaudioside A.
摘要翻译： 三糖和四糖用于食品，饮料和其他消费品中，以掩盖或减少也存在于此类产品中的某些组分的不愉快味道，例如某些高强度甜味剂的苦味 。 产品的感官品质由此得到改善。 特别地，松三糖，麦芽三糖和麦芽四糖有效地降低含甜菊醇糖苷（例如莱鲍迪甙A）的可消耗产品的苦味。
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公开(公告)号：WO2018039056A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/047521
申请日：2017-08-18
IPC分类号： A23L33/135 , A61K35/741
CPC分类号： A61K47/36 , A23L29/35 , A23L33/135 , A23V2002/00 , A61K9/0095 , A61K35/745 , A61K35/747 , C08B30/18 , C08L3/02 , A23V2200/10 , A23V2200/3204 , A23V2250/5114 , A23Y2220/03 , A23Y2300/49 , A61K2300/00
摘要： The present invention relates to the use of maltodextrin as an excipient. In particular, the present invention relates to the use of maltodextrin as an excipient in probiotic formulations. The present invention also relates to a method to provide a probiotics formulation with improved dispersibility and/or shelf life comprising adding maltodextrin to probiotic formulations.
摘要翻译： 本发明涉及麦芽糖糊精作为赋形剂的用途。 具体而言，本发明涉及麦芽糖糊精作为益生菌制剂中的赋形剂的用途。 本发明还涉及提供具有改善的分散性和/或保质期的益生菌制剂的方法，其包括将麦芽糖糊精加入益生菌制剂中。
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10.发明申请METHOD OF PRODUCING BEVERAGES ON THE BASIS OF JUICE AND POWDER FROM THE MUNG BEAN 审中-公开以豆芽汁为基础生产饮料的方法
公开(公告)号：WO2018031587A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/045973
申请日：2017-08-08
申请人： HOANG, Kieu
发明人： HOANG, Kieu
IPC分类号： C12C11/00
CPC分类号： A61K36/48 , A23L2/02 , A23L11/05 , A23V2002/00 , A61K9/0095 , A61K2236/15 , C12C11/00
摘要： A food composition arranged for human consumption comprising a plurality of ingredients, all from Mungbean. The invention provides a process for obtaining juice and powder from Mungbean, wherein the seed of Mungbean is grinded and centrifuged to make juice and powder. Total XXXX protein found in Mungbean. Among them, XXXX are uncharacterized and XXXX are putative uncharacterized new found KH good healthy proteins synthesized by KH good healthy cells.
摘要翻译： 包含全部来自绿豆的多种成分的供人食用的食物组合物。 本发明提供了一种从绿豆中获取果汁和粉末的方法，其中将绿豆种子研磨并离心制成果汁和粉末。 在绿豆中发现总共XXXX蛋白质。 其中，XXXX未被鉴定，XXXX未被认定为新发现的由KH良好健康细胞合成的KH良好健康蛋白质。
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