公开(公告)号：WO2005107396A3

公开(公告)日：2006-03-23

申请号：PCT/US2005014965

申请日：2005-05-02

Applicant: CHIRON CORP ,  MORRIS DAVID W ,  MALANDRO MARC S ,  LAI ALBERT ,  TSE CHRISTIN ,  FATTAEY ALI

Inventor： MORRIS DAVID W ,  MALANDRO MARC S ,  LAI ALBERT ,  TSE CHRISTIN ,  FATTAEY ALI

IPC: C07H21/04 ,  C07K14/47 ,  C12Q1/68

CPC classification number: C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer ­associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that presents novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening prevention and treatment of cancer.

Abstract translation: 本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。 本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。 本发明提供了与癌症相关的CA多肽，其呈递针对癌症的新型治疗靶点。 本发明还提供了用于检测癌症的诊断组合物和方法。 本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。 本发明还提供用于筛选癌症的预防和治疗的诊断工具和治疗组合物和方法。

公开(公告)号：WO2005104810A2

公开(公告)日：2005-11-10

申请号：PCT/US2005/015467

申请日：2005-04-27

Applicant: SAGRES DISCOVERY, INC. ,  LAI, Albert ,  FATTAEY, Ali ,  MORRIS, David, W. ,  MALANDRO, Marc, S. ,  TSE, Christin

Inventor： LAI, Albert ,  FATTAEY, Ali ,  MORRIS, David, W. ,  MALANDRO, Marc, S. ,  TSE, Christin

IPC: C07K14/47 ,  C12Q1/68

CPC classification number: C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer ­associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

Abstract translation: 本发明涉及用于癌症尤其是淋巴瘤的检测，诊断和治疗的新型序列。 本发明提供癌症相关（CA）多核苷酸序列，其表达与癌症相关。 本发明提供了存在于细胞表面上的与癌症相关的CA多肽，并提出了针对癌症的新型治疗靶点。 本发明还提供了用于检测癌症的诊断组合物和方法。 本发明提供对CA多肽具有特异性的单克隆和多克隆抗体。 本发明还提供用于癌症的筛选，预防和治疗的诊断工具和治疗组合物和方法。

公开(公告)号：WO2005087903A1

公开(公告)日：2005-09-22

申请号：PCT/US2005/007663

申请日：2005-03-09

Applicant: CONOCOPHILLIPS COMPANY ,  THE PENN STATE RESEARCH FOUNDATION ,  ESEN, Etop ,  BOEHMAN, Andre, L. ,  MORRIS, David, P.

Inventor： ESEN, Etop ,  BOEHMAN, Andre, L. ,  MORRIS, David, P.

IPC: C10L1/18

CPC classification number: C10L1/19 ,  C10L1/026 ,  C10L1/14 ,  C10L1/1616 ,  C10L1/18 ,  C10L1/1802 ,  C10L1/1826 ,  C10L1/191 ,  C10L10/02 ,  Y02E50/13

Abstract: This invention shows how to make and use a biodiesel-based fuel in diesel engines without incurring the NO x penalty. Embodiments primarily relate to an optimum range of bulk modulus of compressibility for biodiesel blends, which results in generating "NO x neutral" biodiesel blends or to formulate biodiesel blends with lower NO x emissions than conventional petroleum diesel fuel. These biodiesel blends preferably comprise synthetic paraffinic middle distillate derived from a hydrocarbon synthesis to generate synthetic environmentally-friendly diesel fuels.

Abstract translation: 本发明示出了如何在柴油发动机中制造和使用基于生物柴油的燃料，而不会导致NOx损失。 实施方案主要涉及生物柴油混合物的压缩性体积模量的最佳范围，其导致产生“NOx中性”生物柴油共混物或配制具有比常规石油柴油燃料更低的NOx排放的生物柴油混合物。 这些生物柴油混合物优选包含衍生自烃合成的合成链烷烃中间馏分，以产生合成的环保柴油。

公开(公告)号：WO2005028640A8

公开(公告)日：2005-07-07

申请号：PCT/AU2004001256

申请日：2004-09-17

Applicant: UNISEARCH LTD ,  MORRIS DAVID L

Inventor： MORRIS DAVID L

IPC: A61K35/12 ,  C12N5/00 ,  C12N5/071 ,  G01N33/543 ,  C12N5/06 ,  G01N33/483 ,  G01N33/50

CPC classification number: G01N33/54326 ,  A61K35/12 ,  C12N5/067

Abstract: The present invention provides a method for isolating normal hepatocytes, the method comprising the steps of: recovering liver tissue from a patient during a hepatectomy; and isolating normal hepatocytes from unwanted cells present in the recovered tissue by magnetic separation. The invention further provides a method of preparing hepatocytes for transplantation, the method comprising the steps of: recovering liver tissue from a patient during a hepatectomy; and isolating normal hepatocytes from unwanted cells present in the recovered tissue by magnetic separation.

Abstract translation: 本发明提供了分离正常肝细胞的方法，该方法包括以下步骤：在肝切除术期间从患者回收肝组织; 并通过磁选分离来自存在于回收组织中的不需要的细胞的正常肝细胞。 本发明还提供一种制备移植肝细胞的方法，所述方法包括以下步骤：在肝切除术期间从患者回收肝组织; 并通过磁选分离来自存在于回收组织中的不需要的细胞的正常肝细胞。

公开(公告)号：WO2004096901A3

公开(公告)日：2005-06-23

申请号：PCT/US2004008894

申请日：2004-03-24

Applicant: MILLIKEN & CO ,  PATEL BHAWAN ,  MORRIS DAVID L

Inventor： PATEL BHAWAN ,  MORRIS DAVID L

IPC: C08K3/00 ,  C08K3/08 ,  C08K3/22

CPC classification number: C08K3/08 ,  C08K3/015 ,  C08K3/22 ,  C08L21/00

Abstract: This invention relates to certain non-silicone resin cured rubber articles that are made from at least a majority by weight of non-silicone vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as resin curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of non-silicone rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate resin cured rubber articles made therefrom.

Abstract translation: 本发明涉及由至少大部分重量的非硅氧烷硫化橡胶制成的某些非硅树脂固化橡胶制品，其包括银基化合物，以在固化的橡胶制品内提供高度期望的长期抗菌特性。 这样的制品是固体或吹塑（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。 本发明包括非硫基固化体系和诸如树脂固化的试剂的存在，其允许硫化并且不会不可逆地结合银离子，从而导致最终橡胶制品本身的长期抗菌性能。 本发明还包括由至少大部分重量的非硅橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在最终树脂固化橡胶制品中提供非常期望的长期抗微生物特性 由此。

公开(公告)号：WO2004097002A3

公开(公告)日：2005-06-02

申请号：PCT/US2004013286

申请日：2004-04-29

Applicant: MIRIAM HOSPITAL ,  MORRIS DAVID J ,  LATIF SYED ABDUL ,  HARDY MATTHEW P

Inventor： MORRIS DAVID J ,  LATIF SYED ABDUL ,  HARDY MATTHEW P

IPC: A61K31/56 ,  A61K31/57 ,  C12N20060101

CPC classification number: A61K31/56

Abstract: Methods for increasing and decreasing male fertility using selective 11beta-HSD1-dehydrogenase, 11beta-HSD1-reductase and 11beta-HSD2 dehydrogenase modulating compounds are described.

Abstract translation: 描述了使用选择性11beta-HSD1脱氢酶，11beta-HSD1还原酶和11beta-HSD2脱氢酶调节化合物增加和降低雄性生育力的方法。

公开(公告)号：WO03073826A8

公开(公告)日：2005-04-28

申请号：PCT/US0306235

申请日：2003-02-28

Applicant: SAGRES DISCOVERY INC ,  MORRIS DAVID W

Inventor： MORRIS DAVID W

IPC: C12N15/00 ,  G01N33/50 ,  C07H5/04 ,  C07H5/06 ,  C12Q1/00

CPC classification number: G01N33/5011 ,  C07K14/47 ,  Y10T436/25

公开(公告)号：WO2005016832A1

公开(公告)日：2005-02-24

申请号：PCT/US2004/026294

申请日：2004-08-12

Applicant: KNAPP, Ian, M. ,  MORRIS, David, B.

Inventor： KNAPP, Ian, M. ,  MORRIS, David, B.

IPC: C02F1/68

CPC classification number: C02F1/688 ,  C02F1/003 ,  C02F1/76 ,  C02F2201/006 ,  C02F2303/04

Abstract: The water treatment cartridge (10) is a cartridge adapted to fit into a conventional water filter housing (110) to release a sanitizing dose of a water-treating chemical, and in particular chlorine dioxide, into a water treatment system or unit process. The cartridge (10) is filled with a water treating media (38), comprised preferably of a mixture of an inert filler material and a chemical composition that releases chlorine dioxide on contact with water. The concentration of the chlorine dioxide released into the water, as well as the duration of the release, may be varied by the selection of the filler material and amount of the filler material in the water treating media (38).

Abstract translation: 水处理盒（10）是适于装配到常规水过滤器壳体（110）中以将消毒剂量的水处理化学品，特别是二氧化氯释放到水处理系统或单元过程中的筒。 盒（10）填充有水处理介质（38），其优选地包括惰性填料和与水接触释放二氧化氯的化学组成的混合物。 释放到水中的二氧化氯的浓度以及释放的持续时间可以通过填充材料的选择和水处理介质（38）中填充材料的量来改变。

公开(公告)号：WO2004096901A2

公开(公告)日：2004-11-11

申请号：PCT/US2004/008894

申请日：2004-03-24

Applicant: MILLIKEN & COMPANY ,  PATEL, Bhawan ,  MORRIS, David L.

Inventor： PATEL, Bhawan ,  MORRIS, David L.

IPC: C08K

CPC classification number: C08K3/08 ,  C08K3/015 ,  C08K3/22 ,  C08L21/00

Abstract: This invention relates to certain non-silicone resin cured rubber articles that are made from at least a majority by weight of non-silicone vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as resin curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of non-silicone rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate resin cured rubber articles made therefrom.

Abstract translation: 本发明涉及由至少大部分重量的非硅氧烷硫化橡胶制成的某些非硅树脂固化橡胶制品，其包括银基化合物，以在固化的橡胶制品内提供高度期望的长期抗菌特性。 这样的制品是固体或吹塑（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。 本发明包括非硫基固化体系和诸如树脂固化的试剂的存在，其允许硫化并且不会不可逆地结合银离子，从而导致最终橡胶制品本身的长期抗菌性能。 本发明还包括由至少大部分重量的非硅橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在最终树脂固化橡胶制品中提供非常期望的长期抗微生物特性 由此。

公开(公告)号：WO2004074321A3

公开(公告)日：2004-09-02

申请号：PCT/US2004/005000

申请日：2004-02-17

Applicant: SAGRES DISCOVERY, INC. ,  MORRIS, David, W. ,  MALANDRO, Marc, S.

Inventor： MORRIS, David, W. ,  MALANDRO, Marc, S.

IPC: C07K14/47

Abstract: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. This invention relates to G-protein coupled receptor (GPCR) sequences. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.