中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

172 records (took 0.017 seconds)

    A TENDON AND LIGAMENT REPAIR SHEET AND METHODS OF USE
    11.
    发明申请
    A TENDON AND LIGAMENT REPAIR SHEET AND METHODS OF USE 审中-公开
    TENDON和LIGAMENT维修表和使用方法

    公开(公告)号：WO2009079211A1

    公开(公告)日：2009-06-25

    申请号：PCT/US2008/085408

    申请日：2008-12-03

    Applicant: WARSAW ORTHOPEDIC, INC. ,  MCKAY, William F.

    Inventor： MCKAY, William F.

    IPC: A61F2/08

    CPC classification number: A61F2/08

    Abstract: Methods and device for treating or healing an injured tendon or ligament is disclosed. The device, a tendon and ligament repair sheet (1), has a porous layer (2) and a denser layer (3), and optionally a therapeutic agent in the porous layer, the denser layer or both. The repair sheet is made from a resorbable or non-resorbable polymer. The repair sheet is securely attached to the injured tendon, ligament, muscle, or bone and has a suture pull out strength of at least 3N. If the injury involve severing of a ligament or tendon, one should place the severed ends in close proximity to each other and securely attach the repair sheet to both sides of the severed tendon or ligament at a distance from the injury so that the repair sheet remains securely attached to the tendon, ligament, muscle, or bone while the tissue is healing.

    Abstract translation: 公开了治疗或愈合损伤的肌腱或韧带的方法和装置。 该装置，腱和韧带修复片（1）具有多孔层（2）和更致密的层（3），并且任选地在多孔层中的治疗剂，更致密的层或两者都是。 修复片由可再吸收或不可吸收的聚合物制成。 修复片牢固地附着在受伤的肌腱，韧带，肌肉或骨骼上，并具有至少3N的缝合线拔出强度。 如果损伤涉及切断韧带或肌腱，则应将切断的末端彼此靠近，并将修复片牢固地附接到断裂的肌腱或韧带的两侧，距伤口一定距离处，使修复片保留 当组织愈合时，牢固地附着于腱，韧带，肌肉或骨骼。

    METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS
    12.
    发明申请
    METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS 审中-公开
    诱导或增加蛋白质表达的方法如细胞中的AGGRECAN

    公开(公告)号：WO2008156500A4

    公开(公告)日：2009-06-11

    申请号：PCT/US2007084922

    申请日：2007-11-16

    Applicant: WARSAW ORTHOPEDIC INC ,  YOON SANGWOOK T ,  UNIV EMORY ,  BODEN SCOTT D ,  MCKAY WILLIAM F

    Inventor： BODEN SCOTT D ,  MCKAY WILLIAM F

    IPC: C12N15/09

    CPC classification number: A61K38/1841 ,  A61K38/1875 ,  A61K48/005 ,  A61K48/0075

    Abstract: Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplishedex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus).

    Abstract translation: 描述了在细胞中诱导蛋白聚糖如聚集蛋白聚糖表达的方法。 描述了一种方法，其包括用包含与启动子可操作地连接的编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 LIM矿化蛋白可以是rLMP，hLMP-1，hLMP-1或hLMP-3。 转染可以通过直接注射病毒或裸DNA或通过非病毒载体如质粒在体内或体内完成。 该方法可用于在骨细胞中诱导蛋白聚糖合成或刺激能够产生蛋白聚糖和/或胶原的细胞（例如包括髓核细胞和纤维环的椎间盘细胞）中的蛋白聚糖和/或胶原产生。

    METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS
    13.
    发明申请
    METHODS OF INDUCING OR INCREASING THE EXPRESSION OF PROTEOGLYCANS SUCH AS AGGRECAN IN CELLS 审中-公开
    诱导或增加蛋白质表达的方法如细胞中的AGGRECAN

    公开(公告)号：WO2008156500A2

    公开(公告)日：2008-12-24

    申请号：PCT/US2007084922

    申请日：2007-11-16

    Applicant: WARSAW ORTHOPEDIC INC ,  YOON SANGWOOK T ,  UNIV EMORY ,  BODEN SCOTT D ,  MCKAY WILLIAM F

    Inventor： BODEN SCOTT D ,  MCKAY WILLIAM F

    IPC: C12N15/09

    CPC classification number: A61K38/1841 ,  A61K38/1875 ,  A61K48/005 ,  A61K48/0075

    Abstract: Methods of inducing the expression of a proteoglycan such as aggrecan in a cell are described. A method is described which includes transfecting a cell with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. The LIM mineralization protein can be rLMP, hLMP-1, hLMP-1s, or hLMP-3. Transfection maybe accomplishedex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. The method can be used to induce proteoglycan synthesis in osseous cells or to stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycan and/or collagen (e.g., intervertebral disc cells including cells of the nucleus pulposus and annulus fibrosus).

    Abstract translation: 描述了在细胞中诱导蛋白聚糖如聚集蛋白聚糖表达的方法。 描述了一种方法，其包括用包含与启动子可操作地连接的编码LIM矿化蛋白的核苷酸序列的分离的核酸转染细胞。 LIM矿化蛋白可以是rLMP，hLMP-1，hLMP-1或hLMP-3。 转染可以通过直接注射病毒或裸DNA或通过非病毒载体如质粒在体内或体内完成。 该方法可用于在骨细胞中诱导蛋白聚糖合成或刺激能够产生蛋白聚糖和/或胶原的细胞（例如包括髓核细胞和纤维环的椎间盘细胞）中的蛋白聚糖和/或胶原产生。

    FLOWABLE CARRIER COMPOSITIONS AND METHODS OF USE
    14.
    发明申请
    FLOWABLE CARRIER COMPOSITIONS AND METHODS OF USE 审中-公开
    流动载体组合物和使用方法

    公开(公告)号：WO2008079672A3

    公开(公告)日：2008-12-24

    申请号：PCT/US2007087117

    申请日：2007-12-12

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F ,  PECKHAM STEVEN M

    Inventor： MCKAY WILLIAM F ,  PECKHAM STEVEN M

    IPC: A61B19/02 ,  A61B17/00 ,  A61K38/18 ,  A61L27/46 ,  A61L27/58

    CPC classification number: A61K38/1875 ,  A61B17/00491 ,  A61B50/30 ,  A61B2017/00495 ,  A61K9/10

    Abstract: A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.

    Abstract translation: 提供组合物用于更快的骨修复和早期矫形植入物固定。 该组合物包含嵌入载体浆液中的骨诱导或骨源性生物因子。 通过用生物相容性流体润湿可生物降解的聚合物和磷酸钙颗粒来制备浆料。 组合物可以在外科手术过程中应用于骨折部位，矫形植入物或两者。 该组合物利用低剂量的生物因子，因此通常是成本有效的。

    IMPLANT DEPOTS TO DELIVER GROWTH FACTORS TO TREAT OSTEOPOROTIC BONE
    15.
    发明申请
    IMPLANT DEPOTS TO DELIVER GROWTH FACTORS TO TREAT OSTEOPOROTIC BONE 审中-公开
    植入生长因子以治疗骨质疏松

    公开(公告)号：WO2007130930A3

    公开(公告)日：2008-12-18

    申请号：PCT/US2007067862

    申请日：2007-05-01

    Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F

    Inventor： MCKAY WILLIAM F

    IPC: A61L27/22 ,  A61L27/24 ,  A61L27/56

    CPC classification number: A61L27/227 ,  A61K9/0024 ,  A61L27/24 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/604 ,  C08L89/06

    Abstract: The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased bone mineral density in the osteoporotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

    Abstract translation: 本发明涉及用于最佳递送生长因子以治疗骨质疏松性骨的贮库植入物的设计和组成，因为这样的植入物被构造为圆柱（杆）或球形，并且具有天然或合成的聚合物支架 有或没有浸渍的磷酸钙颗粒。 仓库的密度高于典型的BMP海绵载体，以便于其植入和较慢释放生长因子。 支架使得其具有足够的孔隙度和孔径以促进整个骨结构中的生长因子接种和扩散，导致骨质疏松骨中骨矿物质密度增加。 此外，储库植入物的形状允许通过套管或大孔针进行输送。

    COMPOSITIONS AND METHODS INDUCING FIBROSIS
    16.
    发明申请
    COMPOSITIONS AND METHODS INDUCING FIBROSIS 审中-公开
    组合物和诱导纤维化的方法

    公开(公告)号：WO2008089164A1

    公开(公告)日：2008-07-24

    申请号：PCT/US2008/051035

    申请日：2008-01-15

    Applicant: WARSAW ORTHOPEDIC, INC. ,  DRAPEAU, Susan J. ,  MCKAY, William F.

    Inventor： DRAPEAU, Susan J. ,  MCKAY, William F.

    IPC: A61K38/18 ,  A61P19/02

    CPC classification number: A61K38/1841 ,  A61K38/1858 ,  A61K38/1875 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/204 ,  A61K38/212 ,  A61K38/4886 ,  A61L27/227 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/34

    Abstract: Methods and compositions for treating soft tissue defects are provided. The composition, which is injectable directly into the tissue adjacent to the defect, comprises a fibrosis inducing factor in a carrier. The method includes preparing the composition comprising a fibrosis inducing factor in a carrier and delivering the composition into the tissue adjacent to the defect. Alternatively, a carrier matrix may be disposed in or near the defect, a pump capable of delivering an effective amount of a fibrosis inducing factor may be provided, and the pump is fluidly connected to the carrier matrix.

    Abstract translation: 提供了治疗软组织缺陷的方法和组合物。 直接注射到与缺损相邻的组织中的组合物在载体中包含纤维化诱导因子。 该方法包括在载体中制备包含纤维化诱导因子的组合物，并将组合物输送到与缺损相邻的组织中。 或者，可以将载体基质设置在缺陷中或附近，可以提供能够递送有效量的纤维化诱导因子的泵，并且泵与载体基质流体连接。

    COMPOSITIONS COMPRISING BIOMEMBRANE SEALING AGENT FOR TREATMENT OF NEURONAL INJURY, AND METHODS OF USE
    19.
    发明申请
    COMPOSITIONS COMPRISING BIOMEMBRANE SEALING AGENT FOR TREATMENT OF NEURONAL INJURY, AND METHODS OF USE 审中-公开
    包含用于治疗神经损伤的生物膜密封剂的组合物及其使用方法

    公开(公告)号：WO2007130848A3

    公开(公告)日：2008-01-24

    申请号：PCT/US2007067580

    申请日：2007-04-27

    Applicant: WARSAW ORTHOPEDIC INC ,  ROY JOSEE ,  MCKAY WILLIAM F ,  MARX JEFFERY C MD

    Inventor： ROY JOSEE ,  MCKAY WILLIAM F ,  MARX JEFFERY C MD

    IPC: A61K33/06 ,  A61K47/10

    CPC classification number: A61K33/06 ,  A61K9/0019 ,  A61K31/56 ,  A61K31/65 ,  A61K31/765 ,  A61K47/10

    Abstract: The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent may be delivered by a method selected from the group consisting of an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

    Abstract translation: 本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。 在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。 生物膜密封剂和/或生物活性剂可以通过选自静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，肠胃外给药，直接施用于 或与病理状况的位点相邻，以及其任何组合。 或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

    DRUG DEPOT IMPLANT DESIGNS AND METHODS OF IMPLANTATION
    20.
    发明申请
    DRUG DEPOT IMPLANT DESIGNS AND METHODS OF IMPLANTATION 审中-公开

    公开(公告)号：WO2007121288A3

    公开(公告)日：2007-10-25

    申请号：PCT/US2007/066496

    申请日：2007-04-12

    Applicant: WARSAW ORTHOPEDIC, INC. ,  MCKAY, William F.

    Inventor： MCKAY, William F.

    IPC: A61K9/00 ,  A61M37/00

    Abstract: The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.

Patent Agency Ranking