公开(公告)号：WO2010094300A1

公开(公告)日：2010-08-26

申请号：PCT/EP2009/001230

申请日：2009-02-20

Applicant: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITÄT TÜBINGEN ,  JOOS, Thomas ,  TEMPLIN, Markus ,  STOLL, Dieter ,  POETZ, Oliver ,  ZELL, Andreas ,  PLANATSCHER, Hannes ,  SUPPER, Jochen

Inventor： JOOS, Thomas ,  TEMPLIN, Markus ,  STOLL, Dieter ,  POETZ, Oliver ,  ZELL, Andreas ,  PLANATSCHER, Hannes ,  SUPPER, Jochen

IPC: G06F19/00

CPC classification number: G06F19/18

Abstract: A method for determining in silico a set of selected target epitopes suited for the detection of at least one protein of a set of proteins of interest within a pool of sample proteins, comprises the steps of: providing a first list containing the sequences of said sample proteins; providing a second list containing the sequences of said proteins of interest; applying an in silico fragmentation to the sample proteins in said first list to generate a third list containing sequences of possible target peptides having possible target epitopes at their free N- and C-terminal ends, which possible target epitopes each consisting of three to five N- or C-terminal amino acids; generating a fourth list of sequences of valid target peptides by removing from said third list such possible target peptides that are less suited for said protein of interest identification; selecting from said possible target epitopes on said valid target peptides in said fourth list a set of selected target epitopes, said set of selected target epitopes containing at least one target epitope for each protein of interest in said second list, while at the same time containing an as small as possible number of target epitopes.

Abstract translation: 一种用于在计算机中测定一组适合于检测样品蛋白质库中的一组感兴趣的蛋白质的至少一种蛋白质的选定靶标表位的方法，包括以下步骤：提供包含所述样品序列的第一列表 蛋白质; 提供含有所述目的蛋白质序列的第二个列表; 对所述第一列表中的样品蛋白应用计算机碎裂以产生含有其游离N-和C-末端具有可能靶标表位的可能靶肽序列的第三列表，其可能的靶标表位各自包含三至五个N - 或C-末端氨基酸; 通过从所述第三列表中移除不太适合于所述兴趣蛋白质鉴定的可能的靶肽，产生有效靶肽序列的第四列表; 从所述第四列表中的所述有效靶肽上的所述可能靶标表位选择一组所选择的靶标表位，所述选定靶标表位集合在所述第二列表中含有每种感兴趣的蛋白质的至少一个靶表位，同时含有 尽可能少的靶标表位。

公开(公告)号：WO2004027276A1

公开(公告)日：2004-04-01

申请号：PCT/EP2003/009859

申请日：2003-09-05

Applicant: INA-SCHAEFFLER KG ,  STOLL, Dieter ,  EICK, Rüdiger

Inventor： STOLL, Dieter ,  EICK, Rüdiger

IPC: F16C29/08

CPC classification number: F16C29/082 ,  F16C29/005 ,  F16C2300/02

Abstract: Führungsschiene für ein Linearlager, mit mehreren Durchgangsöffnungen (1) für die Aufnahme von Befestigungsschrauben, die in Schienenlängsrichtung in Abständen hintereinander angeordnet sind, und mit einem die Durchgangsöffnungen (1) bedeckenden Deckband (5, 11, 14), das über Magnetkraft an der Führungsschiene gehalten ist.

Abstract translation: 导轨用于直线轴承，带多个通孔（1），用于紧固螺钉的接收其与通孔（1），其覆盖罩（5，11，14）通过在所述导轨上的磁力布置在轨道纵向方向间隔一个在另一个后面，并 维持。

公开(公告)号：WO2002086494A3

公开(公告)日：2002-10-31

申请号：PCT/EP2002/004281

申请日：2002-04-18

Applicant: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITÄT TÜBINGEN ,  JOOS, Thomas ,  STOLL, Dieter ,  TEMPLIN, Markus ,  VIRNEKÄS, Bernhard ,  OSTENDORP, Ralf

Inventor： JOOS, Thomas ,  STOLL, Dieter ,  TEMPLIN, Markus ,  VIRNEKÄS, Bernhard ,  OSTENDORP, Ralf

IPC: G01N33/58

Abstract: A method for determining a first physicochemical property of at least two compounds relative to each other uses a second physicochemical property, whereby determination of said first property depends on a third, undetermined physical property, and said first property depends on the composition of the respective compound. Determination of said second property depends on said third property as well, but said second property does not depend on the composition of the respective compound. For each compound a first value for said first property is measured under certain, preferably equilibrium conditions, and simultaneously a second value for said second physical property under said certain conditions is measured. Said first property for each compound relative to the other compound is determined by using said first and second values.

公开(公告)号：WO2002086494A2

公开(公告)日：2002-10-31

申请号：PCT/EP2002/004281

申请日：2002-04-18

Applicant: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITÄT TÜBINGEN ,  JOOS, Thomas ,  STOLL, Dieter ,  TEMPLIN, Markus ,  VIRNEKÄS, Bernhard ,  OSTENDORP, Ralf

Inventor： JOOS, Thomas ,  STOLL, Dieter ,  TEMPLIN, Markus ,  VIRNEKÄS, Bernhard ,  OSTENDORP, Ralf

IPC: G01N33/00

CPC classification number: G01N33/54306

Abstract: A method for determining a first physicochemical property of at least two compounds relative to each other uses a second physicochemical property, whereby determination of said first property depends on a third, undetermined physical property, and said first property depends on the composition of the respective compound. Determination of said second property depends on said third property as well, but said second property does not depend on the composition of the respective compound. For each compound a first value for said first property is measured under certain, preferably equilibrium conditions, and simultaneously a second value for said second physical property under said certain conditions is measured. Said first property for each compound relative to the other compound is determined by using said first and second values.

Abstract translation: 用于确定至少两种化合物相对于彼此的第一物理化学性质的方法使用第二物理化学性质，其中所述第一性质的测定取决于第三未确定的物理性质，并且所述第一性质取决于各化合物的组成 。 所述第二性质的测定也取决于所述第三性质，但所述第二性质不依赖于各化合物的组成。 对于每种化合物，在某些优选平衡条件下测量所述第一性质的第一值，同时测量在所述某些条件下所述第二物理性质的第二值。 通过使用所述第一和第二值确定每种化合物相对于另一种化合物的所述第一性质。