公开(公告)号：WO2008025579A1

公开(公告)日：2008-03-06

申请号：PCT/EP2007/055472

申请日：2007-06-04

Applicant: Metanomics GmbH ,  WALK, Tilmann B. ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  COELHO PALERMO CUNHA, Georgia ,  FABIAN, Eric ,  STRAUSS, Volker

Inventor： WALK, Tilmann B. ,  LOOSER, Ralf ,  HEROLD, Michael Manfred ,  WIEMER, Jan C. ,  PROKOUDINE, Alexandre ,  LEIBOLD, Edgar ,  VAN RAVENZWAAY, Bennard ,  MELLERT, Werner ,  COELHO PALERMO CUNHA, Georgia ,  FABIAN, Eric ,  STRAUSS, Volker

IPC: G01N33/53

CPC classification number: G01N33/5308 ,  G01N2500/04 ,  G01N2800/22 ,  Y10T436/14 ,  Y10T436/145555

Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predis- position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.

Abstract translation: 本发明涉及诊断溶血性贫血的方法或其前提。 它还涉及确定化合物是否能够诱导受试者的溶血性贫血的方法以及鉴定用于治疗溶血性贫血的药物的方法。 此外，本发明涉及包含代谢物的特征值，包含所述数据收集的数据存储介质的数据收集以及用于诊断溶血性贫血的系统和装置。 最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中的溶血性贫血的诊断装置或组合物的用途。